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Conference Paper: Forming fibrous nanocomposite tissue engineering scaffolds through electrospinning: a comparative study of three fabrication routes

TitleForming fibrous nanocomposite tissue engineering scaffolds through electrospinning: a comparative study of three fabrication routes
Authors
KeywordsCarbonated hydroxyapatite (CHA)
Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)
Electrospinning
Ultrasonification
Nnanocomposite
Issue Date2010
PublisherAshdin Publishing. The Journal's web site is located at http://www.ashdin.com/journals/bda/bda.aspx
Citation
The 22nd International Symposium on Ceramics in Medicine (BIOCERAMICS 22), Daegu, South Korea, 26-29 October 2009. How to Cite?
AbstractDue to osteoconductivity of hydroxyapatite (HA), HA/polymer composite scaffolds have been investigated for bone tissue engineering by various groups. In scaffold fabrication, electrospinning of ultrafine fibrous scaffolds incorporated with substantial amounts of evenly distributed HA nanoparticles is still a challenge. The problem of nanoparticle agglomeration not only reduces the electrospinning efficiency but also undermines the homogeneity of the distribution of the HA nanoparticles along the fibers. In this study, an approach using ultrasonification was developed so as to electrospin fibrous nanocomposite scaffolds having the carbonated HA (CHA) nanosphere content up to about 15 wt% with minimal agglomeration of CHA nanospheres. SEM and EDX results showed an even distribution of CHA nanospheres while FTIR results further confirmed the presence of CHA within the electrospun fibers. The nanocomposite fibrous scaffolds fabricated through this route could be used in further investigations for bone tissue engineering applications.
DescriptionBioceramics Development and Applications, 2010, v. 1, article no. D110107, p. 1-4
Persistent Identifierhttp://hdl.handle.net/10722/126322

 

DC FieldValueLanguage
dc.contributor.authorTong, HWen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2010-10-31T12:22:01Z-
dc.date.available2010-10-31T12:22:01Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 22nd International Symposium on Ceramics in Medicine (BIOCERAMICS 22), Daegu, South Korea, 26-29 October 2009.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126322-
dc.descriptionBioceramics Development and Applications, 2010, v. 1, article no. D110107, p. 1-4-
dc.description.abstractDue to osteoconductivity of hydroxyapatite (HA), HA/polymer composite scaffolds have been investigated for bone tissue engineering by various groups. In scaffold fabrication, electrospinning of ultrafine fibrous scaffolds incorporated with substantial amounts of evenly distributed HA nanoparticles is still a challenge. The problem of nanoparticle agglomeration not only reduces the electrospinning efficiency but also undermines the homogeneity of the distribution of the HA nanoparticles along the fibers. In this study, an approach using ultrasonification was developed so as to electrospin fibrous nanocomposite scaffolds having the carbonated HA (CHA) nanosphere content up to about 15 wt% with minimal agglomeration of CHA nanospheres. SEM and EDX results showed an even distribution of CHA nanospheres while FTIR results further confirmed the presence of CHA within the electrospun fibers. The nanocomposite fibrous scaffolds fabricated through this route could be used in further investigations for bone tissue engineering applications.-
dc.languageengen_HK
dc.publisherAshdin Publishing. The Journal's web site is located at http://www.ashdin.com/journals/bda/bda.aspx-
dc.relation.ispartofInternational Symposium on Ceramics in Medicine-
dc.subjectCarbonated hydroxyapatite (CHA)-
dc.subjectPoly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)-
dc.subjectElectrospinning-
dc.subjectUltrasonification-
dc.subjectNnanocomposite-
dc.titleForming fibrous nanocomposite tissue engineering scaffolds through electrospinning: a comparative study of three fabrication routesen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailTong, HW: boris0119@gmail.comen_HK
dc.identifier.emailWang, M: memwang@hkucc.hku.hken_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.4303/bda/D110107-
dc.identifier.hkuros173108en_HK
dc.identifier.hkuros177704-
dc.identifier.hkuros189910-
dc.identifier.volume1-
dc.identifier.spage1-
dc.identifier.epage4-

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