Conference Paper: Susceptibility of the optic nerve and the involvement of retrograde neuronal degeneration in a delayed radiation induced injury model: evidence from a diffusion tensor imaging study

TitleSusceptibility of the optic nerve and the involvement of retrograde neuronal degeneration in a delayed radiation induced injury model: evidence from a diffusion tensor imaging study
Authors
Issue Date2010
Citation
The ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010. How to Cite?
AbstractIn the present study, we evaluated changes of multiple white matter tracts following radiation using diffusion tensor imaging. A novel finding of severe changes in FA in the contralateral optic nerve as compared to the ipsilateral optic nerve was observed, and these changes were confirmed by histological evaluation. These findings cannot be explained by difference in radiation dose and suggests, for the first time, an important role of retrograde neuronal degeneration in the underlying mechanism for radiation induced injury to the visual pathway. The results also suggest susceptibility of the optic nerve relative to the cerebral peduncle.
DescriptionAnimal Models of White Matter Disease & Neurodegeneration: No. 469
Persistent Identifierhttp://hdl.handle.net/10722/126027

 

DC FieldValueLanguage
dc.contributor.authorQiu, Den_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-10-31T12:05:45Z-
dc.date.available2010-10-31T12:05:45Z-
dc.date.issued2010en_HK
dc.identifier.citationThe ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126027-
dc.descriptionAnimal Models of White Matter Disease & Neurodegeneration: No. 469-
dc.description.abstractIn the present study, we evaluated changes of multiple white matter tracts following radiation using diffusion tensor imaging. A novel finding of severe changes in FA in the contralateral optic nerve as compared to the ipsilateral optic nerve was observed, and these changes were confirmed by histological evaluation. These findings cannot be explained by difference in radiation dose and suggests, for the first time, an important role of retrograde neuronal degeneration in the underlying mechanism for radiation induced injury to the visual pathway. The results also suggest susceptibility of the optic nerve relative to the cerebral peduncle.-
dc.languageengen_HK
dc.relation.ispartofISMRM-ESMRMB Joint Annual Meeting-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSusceptibility of the optic nerve and the involvement of retrograde neuronal degeneration in a delayed radiation induced injury model: evidence from a diffusion tensor imaging studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailQiu, D: dgiu@hku.hken_HK
dc.identifier.emailWang, S: pkuwangsilun@yahoo.com.cnen_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hk-
dc.description.naturepostprint-
dc.identifier.hkuros172117en_HK

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