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Conference Paper: Assessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transfer

TitleAssessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transfer
Authors
Kim, MChan, QAnthony, MCheung, KMCSamartzis, DChan, TKhong, PL
Issue Date2010
PublisherInternational Society of ISMRM.
Citation
The 2010 Joint Annual Meeting of ISMRM-ESMRMB, Stockholm, Sweden, 1-7 May 2010. How to Cite?
AbstractDetecting early disc degeneration is of vital importance in order to identify subjects that are suitable for treatment. However, current diagnostic techniques are not sensitive to the early stages of intervertebral disc (IVD) degeneration, which involves the loss of proteoglycans. Recently, it has been suggested that glycosaminoglycan content can be quantified by chemical exchange saturation transfer (gagCEST). In the present work, we conducted gagCEST imaging for IVDs of human volunteers. Our results show that in vivo gagCEST quantification is feasible at 3 Tesla and may potentially be a useful clinical tool in identifying early degenerative changes in the human IVDs.
Persistent Identifierhttp://hdl.handle.net/10722/126022

 

DC FieldValueLanguage
dc.contributor.authorKim, Men_HK
dc.contributor.authorChan, Qen_HK
dc.contributor.authorAnthony, Men_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorSamartzis, Den_HK
dc.contributor.authorChan, Ten_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-10-31T12:05:28Z-
dc.date.available2010-10-31T12:05:28Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 2010 Joint Annual Meeting of ISMRM-ESMRMB, Stockholm, Sweden, 1-7 May 2010.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126022-
dc.description.abstractDetecting early disc degeneration is of vital importance in order to identify subjects that are suitable for treatment. However, current diagnostic techniques are not sensitive to the early stages of intervertebral disc (IVD) degeneration, which involves the loss of proteoglycans. Recently, it has been suggested that glycosaminoglycan content can be quantified by chemical exchange saturation transfer (gagCEST). In the present work, we conducted gagCEST imaging for IVDs of human volunteers. Our results show that in vivo gagCEST quantification is feasible at 3 Tesla and may potentially be a useful clinical tool in identifying early degenerative changes in the human IVDs.-
dc.languageengen_HK
dc.publisherInternational Society of ISMRM.-
dc.relation.ispartofISMRM-ESMRMB 2010 Joint Annual Meeting-
dc.titleAssessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transferen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailKim, M: minakim@hku.hken_HK
dc.identifier.emailAnthony, M: anthonym@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailSamartzis, D: dsamartzis@msn.comen_HK
dc.identifier.emailChan, T: taochan@hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.authorityKim, M=rp00292en_HK
dc.identifier.authorityAnthony, M=rp01302en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authoritySamartzis, D=rp01430en_HK
dc.identifier.authorityChan, T=rp00289en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.hkuros172128en_HK
dc.description.otherThe 2010 Joint Annual Meeting of ISMRM-ESMRMB, Stockholm, Sweden, 1-7 May 2010.-

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