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Conference Paper: Characterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imaging
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TitleCharacterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imaging
 
AuthorsWang, S
Wu, EX
Lau, HF
Gu, J
Zhou, J
Khong, PL
 
Issue Date2010
 
CitationThe ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010. [How to Cite?]
 
AbstractWe evaluated hypoxic-ischemic (HI)-induced white matter (WM) injury in a mild HI neonatal rat model from Day1 to 90 post-HI by DTI. Results showed that significantly decreased FA in multiple injured WM tracts, including external capsule (EC), fornix (F), cerebral peduncle (CP) and optical tracts (OT), at different time points, but no differences were demonstrated in anterior commissure (AC). Our results support the use of DTI as an imaging biomarker to non-invasively monitor the severity and longitudinal changes of mild HI-induced WM injury. Different severity and patterns of WM tract injury may reflect disturbances of cerebral blood supply in this ischemic animal model.
 
DescriptionPosters - Animal Models of Stroke & Ischemia: No. 4492
 
DC FieldValue
dc.contributor.authorWang, S
 
dc.contributor.authorWu, EX
 
dc.contributor.authorLau, HF
 
dc.contributor.authorGu, J
 
dc.contributor.authorZhou, J
 
dc.contributor.authorKhong, PL
 
dc.date.accessioned2010-10-31T12:05:11Z
 
dc.date.available2010-10-31T12:05:11Z
 
dc.date.issued2010
 
dc.description.abstractWe evaluated hypoxic-ischemic (HI)-induced white matter (WM) injury in a mild HI neonatal rat model from Day1 to 90 post-HI by DTI. Results showed that significantly decreased FA in multiple injured WM tracts, including external capsule (EC), fornix (F), cerebral peduncle (CP) and optical tracts (OT), at different time points, but no differences were demonstrated in anterior commissure (AC). Our results support the use of DTI as an imaging biomarker to non-invasively monitor the severity and longitudinal changes of mild HI-induced WM injury. Different severity and patterns of WM tract injury may reflect disturbances of cerebral blood supply in this ischemic animal model.
 
dc.descriptionPosters - Animal Models of Stroke & Ischemia: No. 4492
 
dc.identifier.citationThe ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010. [How to Cite?]
 
dc.identifier.hkuros172124
 
dc.identifier.urihttp://hdl.handle.net/10722/126017
 
dc.languageeng
 
dc.relation.ispartofISMRM-ESMRMB Joint Annual Meeting
 
dc.titleCharacterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imaging
 
dc.typeConference_Paper
 
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<contributor.author>Wu, EX</contributor.author>
<contributor.author>Lau, HF</contributor.author>
<contributor.author>Gu, J</contributor.author>
<contributor.author>Zhou, J</contributor.author>
<contributor.author>Khong, PL</contributor.author>
<date.accessioned>2010-10-31T12:05:11Z</date.accessioned>
<date.available>2010-10-31T12:05:11Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>The ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010.</identifier.citation>
<identifier.uri>http://hdl.handle.net/10722/126017</identifier.uri>
<description>Posters - Animal Models of Stroke &amp; Ischemia: No. 4492</description>
<description.abstract>We evaluated hypoxic-ischemic (HI)-induced white matter (WM) injury in a mild HI neonatal rat model from Day1 to 90 post-HI by DTI. Results showed that significantly decreased FA in multiple injured WM tracts, including external capsule (EC), fornix (F), cerebral peduncle (CP) and optical tracts (OT), at different time points, but no differences were demonstrated in anterior commissure (AC). Our results support the use of DTI as an imaging biomarker to non-invasively monitor the severity and longitudinal changes of mild HI-induced WM injury. Different severity and patterns of WM tract injury may reflect disturbances of cerebral blood supply in this ischemic animal model.</description.abstract>
<language>eng</language>
<relation.ispartof>ISMRM-ESMRMB Joint Annual Meeting</relation.ispartof>
<title>Characterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imaging</title>
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