Conference Paper: Characterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imaging
| Title | Characterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imaging |
|---|---|
| Authors | Wang, S Wu, EX Lau, HF Gu, J Zhou, J Khong, PL |
| Issue Date | 2010 |
| Citation | The ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010. [How to Cite?] |
| Abstract | We evaluated hypoxic-ischemic (HI)-induced white matter (WM) injury in a mild HI neonatal rat model from Day1 to 90 post-HI by DTI. Results showed that significantly decreased FA in multiple injured WM tracts, including external capsule (EC), fornix (F), cerebral peduncle (CP) and optical tracts (OT), at different time points, but no differences were demonstrated in anterior commissure (AC). Our results support the use of DTI as an imaging biomarker to non-invasively monitor the severity and longitudinal changes of mild HI-induced WM injury. Different severity and patterns of WM tract injury may reflect disturbances of cerebral blood supply in this ischemic animal model. |
| Description | Posters - Animal Models of Stroke & Ischemia: No. 4492 |
| dc.contributor.author | Wang, S |
|---|---|
| dc.contributor.author | Wu, EX |
| dc.contributor.author | Lau, HF |
| dc.contributor.author | Gu, J |
| dc.contributor.author | Zhou, J |
| dc.contributor.author | Khong, PL |
| dc.date.accessioned | 2010-10-31T12:05:11Z |
| dc.date.available | 2010-10-31T12:05:11Z |
| dc.date.issued | 2010 |
| dc.description.abstract | We evaluated hypoxic-ischemic (HI)-induced white matter (WM) injury in a mild HI neonatal rat model from Day1 to 90 post-HI by DTI. Results showed that significantly decreased FA in multiple injured WM tracts, including external capsule (EC), fornix (F), cerebral peduncle (CP) and optical tracts (OT), at different time points, but no differences were demonstrated in anterior commissure (AC). Our results support the use of DTI as an imaging biomarker to non-invasively monitor the severity and longitudinal changes of mild HI-induced WM injury. Different severity and patterns of WM tract injury may reflect disturbances of cerebral blood supply in this ischemic animal model. |
| dc.description | Posters - Animal Models of Stroke & Ischemia: No. 4492 |
| dc.identifier.citation | The ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden, 1-7 May 2010. [How to Cite?] |
| dc.identifier.hkuros | 172124 |
| dc.identifier.uri | http://hdl.handle.net/10722/126017 |
| dc.language | eng |
| dc.relation.ispartof | ISMRM-ESMRMB Joint Annual Meeting |
| dc.title | Characterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imaging |
| dc.type | Conference_Paper |