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Conference Paper: Characterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imaging

TitleCharacterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imaging
Authors
Wang, SWu, EXLau, HFGu, JZhou, JKhong, PL
Issue Date2010
Citation
The 2010 ISMRM-ESMRMB Joint Annual Meeting, Stockholm, Sweden, 1-7 May 2010. How to Cite?
AbstractWe evaluated hypoxic-ischemic (HI)-induced white matter (WM) injury in a mild HI neonatal rat model from Day1 to 90 post-HI by DTI. Results showed that significantly decreased FA in multiple injured WM tracts, including external capsule (EC), fornix (F), cerebral peduncle (CP) and optical tracts (OT), at different time points, but no differences were demonstrated in anterior commissure (AC). Our results support the use of DTI as an imaging biomarker to non-invasively monitor the severity and longitudinal changes of mild HI-induced WM injury. Different severity and patterns of WM tract injury may reflect disturbances of cerebral blood supply in this ischemic animal model.
DescriptionPosters - Animal Models of Stroke & Ischemia: No. 4492
Persistent Identifierhttp://hdl.handle.net/10722/126017

 

DC FieldValueLanguage
dc.contributor.authorWang, Sen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorLau, HFen_HK
dc.contributor.authorGu, Jen_HK
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-10-31T12:05:11Z-
dc.date.available2010-10-31T12:05:11Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 2010 ISMRM-ESMRMB Joint Annual Meeting, Stockholm, Sweden, 1-7 May 2010.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126017-
dc.descriptionPosters - Animal Models of Stroke & Ischemia: No. 4492-
dc.description.abstractWe evaluated hypoxic-ischemic (HI)-induced white matter (WM) injury in a mild HI neonatal rat model from Day1 to 90 post-HI by DTI. Results showed that significantly decreased FA in multiple injured WM tracts, including external capsule (EC), fornix (F), cerebral peduncle (CP) and optical tracts (OT), at different time points, but no differences were demonstrated in anterior commissure (AC). Our results support the use of DTI as an imaging biomarker to non-invasively monitor the severity and longitudinal changes of mild HI-induced WM injury. Different severity and patterns of WM tract injury may reflect disturbances of cerebral blood supply in this ischemic animal model.-
dc.languageengen_HK
dc.relation.ispartofISMRM-ESMRMB 2010 Joint Annual Meeting-
dc.titleCharacterization of mild hypoxic-ischemic injury in multiple white matter tracts in a neonatal rat model by diffusion tensor MR imagingen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWang, S: pkuwangsilun@yahoo.com.cnen_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.emailLau, HF: lauhofai@gmail.comen_HK
dc.identifier.emailGu, J: gujing2009@hotmail.comen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.identifier.hkuros172124en_HK

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