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Conference Paper: Assessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transfer

TitleAssessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transfer
Authors
Issue Date2010
Citation
The 2010 World Forum for Spine Research (WFSR 2010): The Intervertebral Disc, Montreal, Canada, 5-8 July 2010. How to Cite?
AbstractOBJECTIVE: Low back pain is a global concern with tremendous socioeconomic implications which may severely diminish functional activity, decrease quality of life, lead to loss of wages, and increase health-care costs [1]. Intervertebral disc (IVD) degeneration is a factor strongly associated with low back pain. Composed of a central nucleus pulposus (NP) rich in proteoglycan (PG) content (protein core with glycosaminoglycans (GAGs)) and an outer fibrous annulus fibrosus (AF), the IVD has been noted to degenerate as characterized by biochemical and morphological changes [2-3]. Loss of GAGs is known as an initiating factor in degenerative disc disease (DDD), followed by the reduction of the osmotic pressure and shrinkage of the disc height as a consequence. As it has been suggested that treatment can only stop disc degeneration but not reverse it, it is essential to diagnose early degenerative changes at the stage of GAGs loss by non-invasively quantifying the GAGs content. This is not possible using the sequences currently used in routine practice. Recent studies have proposed that chemical exchange saturation transfer (CEST) can be specific for ...
DescriptionSymposium 5: Diagnosis & tools. S5.8
Persistent Identifierhttp://hdl.handle.net/10722/126001

 

DC FieldValueLanguage
dc.contributor.authorKim, Men_HK
dc.contributor.authorChan, Qen_HK
dc.contributor.authorAnthony, MPen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorSamartzis, Den_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-10-31T12:04:18Z-
dc.date.available2010-10-31T12:04:18Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 2010 World Forum for Spine Research (WFSR 2010): The Intervertebral Disc, Montreal, Canada, 5-8 July 2010.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126001-
dc.descriptionSymposium 5: Diagnosis & tools. S5.8-
dc.description.abstractOBJECTIVE: Low back pain is a global concern with tremendous socioeconomic implications which may severely diminish functional activity, decrease quality of life, lead to loss of wages, and increase health-care costs [1]. Intervertebral disc (IVD) degeneration is a factor strongly associated with low back pain. Composed of a central nucleus pulposus (NP) rich in proteoglycan (PG) content (protein core with glycosaminoglycans (GAGs)) and an outer fibrous annulus fibrosus (AF), the IVD has been noted to degenerate as characterized by biochemical and morphological changes [2-3]. Loss of GAGs is known as an initiating factor in degenerative disc disease (DDD), followed by the reduction of the osmotic pressure and shrinkage of the disc height as a consequence. As it has been suggested that treatment can only stop disc degeneration but not reverse it, it is essential to diagnose early degenerative changes at the stage of GAGs loss by non-invasively quantifying the GAGs content. This is not possible using the sequences currently used in routine practice. Recent studies have proposed that chemical exchange saturation transfer (CEST) can be specific for ...-
dc.languageengen_HK
dc.relation.ispartofWorld Forum of Spine Research: The Intervertebral Disc-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAssessment of glycosaminoglycan distribution in human lumbar intervertebral discs using chemical exchange saturation transferen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailKim, M: minakim@hku.hken_HK
dc.identifier.emailAnthony, MP: anthonym@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailSamartzis, D: dsamartzis@msn.comen_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_HK
dc.description.naturepostprint-
dc.identifier.hkuros173092en_HK
dc.identifier.hkuros255964-

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