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Conference Paper: Selenium deficiency is associated with adverse vascular function in patients with high risk for vascular events
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TitleSelenium deficiency is associated with adverse vascular function in patients with high risk for vascular events
 
AuthorsChan, YH
Siu, CW
Yiu, KH
Chan, HT
Li, SW
Lau, CP
Lam, TH
Tse, HF
 
KeywordsMedical sciences
Cardiovascular diseases
 
Issue Date2010
 
PublisherSage Publications Ltd. The Journal's web site is located at http://cpr.sagepub.com/
 
CitationEuroPRevent 2010, Prague, Czech Republic, 5-7 May 2010. In European Journal of Cardiovascular Prevention & Rehabilitation, 2010, v. 17 n. 2, suppl., p. S71, abstract P334 [How to Cite?]
 
AbstractBACKGROUND: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins relevant to the protection against cardiovascular disease. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. METHODS: We studied 306 consecutive patients with high risk for vascular events (coronary artery disease 35%, acute/ recurrent ischemic stroke 40%, diabetes 58%). Non-invasive brachial-ankle pulse wave velocity (baPWV) was measured using vascular profiling system (VP-2000). Longterm intake of selenium was determined by a validated food frequency questionnaire. RESULTS: Mean daily selenium intake was 59.4 +/- 52.1 mcg/day. Mean baPWV was 1782.4 +/- 418.4 m/s indicating increased arterial stiffness overall. Patients with selenium intake <10th percentile had significantly higher baPWV as compared to patients with intake ? 10th percentile (1994.4 +/- 662.6 m/s versus 1761.0 +/- 380.8 m/s, P=0.005). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/ financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake <10th percentile remained independently predictive of increased baPWV by 768.5 m/s [95% CI: 1345.0-192.0 m/s, P=0.010]. CONCLUSION: Selenium deficiency is associated with worsening arterial stiffness in patients with high risk for vascular events.
 
DescriptionThis journal suppl. caontin EuroPRevent Congress Abstracts May 2010
Poster Session III: Prevention and health policy: obesity, nutrition and health services
Topic: Nutrition
 
ISSN1741-8267
2013 Impact Factor: 3.691
 
DC FieldValue
dc.contributor.authorChan, YH
 
dc.contributor.authorSiu, CW
 
dc.contributor.authorYiu, KH
 
dc.contributor.authorChan, HT
 
dc.contributor.authorLi, SW
 
dc.contributor.authorLau, CP
 
dc.contributor.authorLam, TH
 
dc.contributor.authorTse, HF
 
dc.date.accessioned2010-10-31T12:03:27Z
 
dc.date.available2010-10-31T12:03:27Z
 
dc.date.issued2010
 
dc.description.abstractBACKGROUND: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins relevant to the protection against cardiovascular disease. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. METHODS: We studied 306 consecutive patients with high risk for vascular events (coronary artery disease 35%, acute/ recurrent ischemic stroke 40%, diabetes 58%). Non-invasive brachial-ankle pulse wave velocity (baPWV) was measured using vascular profiling system (VP-2000). Longterm intake of selenium was determined by a validated food frequency questionnaire. RESULTS: Mean daily selenium intake was 59.4 +/- 52.1 mcg/day. Mean baPWV was 1782.4 +/- 418.4 m/s indicating increased arterial stiffness overall. Patients with selenium intake <10th percentile had significantly higher baPWV as compared to patients with intake ? 10th percentile (1994.4 +/- 662.6 m/s versus 1761.0 +/- 380.8 m/s, P=0.005). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/ financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake <10th percentile remained independently predictive of increased baPWV by 768.5 m/s [95% CI: 1345.0-192.0 m/s, P=0.010]. CONCLUSION: Selenium deficiency is associated with worsening arterial stiffness in patients with high risk for vascular events.
 
dc.descriptionThis journal suppl. caontin EuroPRevent Congress Abstracts May 2010
 
dc.descriptionPoster Session III: Prevention and health policy: obesity, nutrition and health services
 
dc.descriptionTopic: Nutrition
 
dc.identifier.citationEuroPRevent 2010, Prague, Czech Republic, 5-7 May 2010. In European Journal of Cardiovascular Prevention & Rehabilitation, 2010, v. 17 n. 2, suppl., p. S71, abstract P334 [How to Cite?]
 
dc.identifier.epageS71
 
dc.identifier.hkuros179884
 
dc.identifier.hkuros182906
 
dc.identifier.issn1741-8267
2013 Impact Factor: 3.691
 
dc.identifier.issue2, suppl.
 
dc.identifier.spageS71
 
dc.identifier.urihttp://hdl.handle.net/10722/125987
 
dc.identifier.volume17
 
dc.languageeng
 
dc.publisherSage Publications Ltd. The Journal's web site is located at http://cpr.sagepub.com/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofEuropean Journal of Cardiovascular Prevention & Rehabilitation
 
dc.rightsEuropean Journal of Cardiovascular Prevention & Rehabilitation. Copyright © Sage Publications Ltd.
 
dc.subjectMedical sciences
 
dc.subjectCardiovascular diseases
 
dc.titleSelenium deficiency is associated with adverse vascular function in patients with high risk for vascular events
 
dc.typeConference_Paper
 
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<contributor.author>Siu, CW</contributor.author>
<contributor.author>Yiu, KH</contributor.author>
<contributor.author>Chan, HT</contributor.author>
<contributor.author>Li, SW</contributor.author>
<contributor.author>Lau, CP</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Tse, HF</contributor.author>
<date.accessioned>2010-10-31T12:03:27Z</date.accessioned>
<date.available>2010-10-31T12:03:27Z</date.available>
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<identifier.citation>EuroPRevent 2010, Prague, Czech Republic, 5-7 May 2010. In European Journal of Cardiovascular Prevention &amp; Rehabilitation, 2010, v. 17 n. 2, suppl., p. S71, abstract P334</identifier.citation>
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<description>Poster Session III: Prevention and health policy: obesity, nutrition and health services</description>
<description>Topic: Nutrition</description>
<description.abstract>BACKGROUND: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins relevant to the protection against cardiovascular disease. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. METHODS: We studied 306 consecutive patients with high risk for vascular events (coronary artery disease 35%, acute/ recurrent ischemic stroke 40%, diabetes 58%). Non-invasive brachial-ankle pulse wave velocity (baPWV) was measured using vascular profiling system (VP-2000). Longterm intake of selenium was determined by a validated food frequency questionnaire. RESULTS: Mean daily selenium intake was 59.4 +/- 52.1 mcg/day. Mean baPWV was 1782.4 +/- 418.4 m/s indicating increased arterial stiffness overall. Patients with selenium intake &lt;10th percentile had significantly higher baPWV as compared to patients with intake ? 10th percentile (1994.4 +/- 662.6 m/s versus 1761.0 +/- 380.8 m/s, P=0.005). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/ financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake &lt;10th percentile remained independently predictive of increased baPWV by 768.5 m/s [95% CI: 1345.0-192.0 m/s, P=0.010]. CONCLUSION: Selenium deficiency is associated with worsening arterial stiffness in patients with high risk for vascular events.</description.abstract>
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