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Conference Paper: Selenium deficiency is associated with adverse vascular function in patients with high risk for vascular events

TitleSelenium deficiency is associated with adverse vascular function in patients with high risk for vascular events
Authors
KeywordsMedical sciences
Cardiovascular diseases
Issue Date2010
PublisherSage Publications Ltd. The Journal's web site is located at http://cpr.sagepub.com/
Citation
EuroPRevent 2010, Prague, Czech Republic, 5-7 May 2010. In European Journal of Cardiovascular Prevention & Rehabilitation, 2010, v. 17 n. 2, suppl., p. S71, abstract P334 How to Cite?
Abstract
BACKGROUND: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins relevant to the protection against cardiovascular disease. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. METHODS: We studied 306 consecutive patients with high risk for vascular events (coronary artery disease 35%, acute/ recurrent ischemic stroke 40%, diabetes 58%). Non-invasive brachial-ankle pulse wave velocity (baPWV) was measured using vascular profiling system (VP-2000). Longterm intake of selenium was determined by a validated food frequency questionnaire. RESULTS: Mean daily selenium intake was 59.4 +/- 52.1 mcg/day. Mean baPWV was 1782.4 +/- 418.4 m/s indicating increased arterial stiffness overall. Patients with selenium intake <10th percentile had significantly higher baPWV as compared to patients with intake ? 10th percentile (1994.4 +/- 662.6 m/s versus 1761.0 +/- 380.8 m/s, P=0.005). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/ financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake <10th percentile remained independently predictive of increased baPWV by 768.5 m/s [95% CI: 1345.0-192.0 m/s, P=0.010]. CONCLUSION: Selenium deficiency is associated with worsening arterial stiffness in patients with high risk for vascular events.
DescriptionThis journal suppl. caontin EuroPRevent Congress Abstracts May 2010
Persistent Identifierhttp://hdl.handle.net/10722/125987
ISSN
2013 Impact Factor: 3.691

 

DC FieldValueLanguage
dc.contributor.authorChan, YHen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorChan, HTen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-10-31T12:03:27Z-
dc.date.available2010-10-31T12:03:27Z-
dc.date.issued2010en_HK
dc.identifier.citationEuroPRevent 2010, Prague, Czech Republic, 5-7 May 2010. In European Journal of Cardiovascular Prevention & Rehabilitation, 2010, v. 17 n. 2, suppl., p. S71, abstract P334en_HK
dc.identifier.issn1741-8267-
dc.identifier.urihttp://hdl.handle.net/10722/125987-
dc.descriptionThis journal suppl. caontin EuroPRevent Congress Abstracts May 2010-
dc.descriptionPoster Session III: Prevention and health policy: obesity, nutrition and health services-
dc.descriptionTopic: Nutrition-
dc.description.abstractBACKGROUND: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins relevant to the protection against cardiovascular disease. However, the relationship between selenium deficiency and vascular function in clinical context remains unknown. METHODS: We studied 306 consecutive patients with high risk for vascular events (coronary artery disease 35%, acute/ recurrent ischemic stroke 40%, diabetes 58%). Non-invasive brachial-ankle pulse wave velocity (baPWV) was measured using vascular profiling system (VP-2000). Longterm intake of selenium was determined by a validated food frequency questionnaire. RESULTS: Mean daily selenium intake was 59.4 +/- 52.1 mcg/day. Mean baPWV was 1782.4 +/- 418.4 m/s indicating increased arterial stiffness overall. Patients with selenium intake <10th percentile had significantly higher baPWV as compared to patients with intake ? 10th percentile (1994.4 +/- 662.6 m/s versus 1761.0 +/- 380.8 m/s, P=0.005). After adjusting for potential confounders including age, gender, history of hypertension, hyperlipidemia, diabetes and cardiovascular disease, smoking status, use of cardiovascular medications, waist-hip ratio, education/ financial status, physical activity, calorie intake and intake of antioxidant vitamins, deficient selenium intake <10th percentile remained independently predictive of increased baPWV by 768.5 m/s [95% CI: 1345.0-192.0 m/s, P=0.010]. CONCLUSION: Selenium deficiency is associated with worsening arterial stiffness in patients with high risk for vascular events.-
dc.languageengen_HK
dc.publisherSage Publications Ltd. The Journal's web site is located at http://cpr.sagepub.com/en_HK
dc.relation.ispartofEuropean Journal of Cardiovascular Prevention & Rehabilitation-
dc.rightsEuropean Journal of Cardiovascular Prevention & Rehabilitation. Copyright © Sage Publications Ltd.-
dc.subjectMedical sciences-
dc.subjectCardiovascular diseases-
dc.titleSelenium deficiency is associated with adverse vascular function in patients with high risk for vascular eventsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, YH: chanwill@hku.hken_HK
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH: khkyiu@hku.hken_HK
dc.identifier.emailLi, SW: swan_li@hotmail.comen_HK
dc.identifier.emailLau, CP: cplau@hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hku.hken_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.authorityChan, YH=rp01313en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.hkuros179884en_HK
dc.identifier.hkuros182906-
dc.identifier.volume17-
dc.identifier.issue2, suppl.-
dc.identifier.spageS71-
dc.identifier.epageS71-
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 130712-

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