File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL

Conference Paper: Heightened systemic oxidative stress critically accelerates worsening carotid atherosclerosis in patients with ischemic stroke

TitleHeightened systemic oxidative stress critically accelerates worsening carotid atherosclerosis in patients with ischemic stroke
Authors
KeywordsMedical sciences
Cardiovascular diseases
Issue Date2010
PublisherSage Publications Ltd. The Journal's web site is located at http://cpr.sagepub.com/
Citation
EuroPRevent 2010, Prague, Czech Republic, 5-7 May 2010. In European Journal of Cardiovascular Prevention & Rehabilitation, 2010, v. 17 n. 2, suppl., p. S99, abstract P480 How to Cite?
AbstractBACKGROUND: Both increased oxidative and inflammatory stresses are implicated in atherogenesis. However, little is known about their role in atherosclerotic progression in patients already at the advanced cardiovascular continuum. OBJECTIVE: To investigate the impact of oxidative and inflammatory stress on the progression of carotid atherosclerosis in patients with established ischemic stroke. METHODS: A total of 43 consecutive patients (mean age 65.7 +/- 8.8 years; male 70%) with primary or recurrent ischemic stroke (>6 months) were recruited from our medical outpatient clinics. High resolution ultrasound (Agilent Sonos 5500, Philips, USA) was used to assess burden of carotid atherosclerosis in terms of maximum intima-media thickness (mIMT). Serum malodialdehyde (MDA) and high-sensitivity C-reactive protein (hsCRP) were respectively measured as markers of systemic oxidative and inflammatory stress. RESULTS: These patients showed a mean mIMT of 2.25 +/- 0.98 mm. Serum MDA (Pearson r=0.32, P=0.035) and hsCRP (Pearson r=0.41, P=0.007) were both positively associated with mIMT. Adjusting for potential confounders by multivariate model (age, gender, hypertension, diabetes mellitus, hyperlipidemia, smoking history, use of aspirin/ statins/ antihypertensives and body-mass index), each 1 c,M increase in serum MDA independently predicted increase in mIMT by 0.79mm(95%CI [0.23 1.36], P=0.008). Furthermore, each 1 mg/L increase of hsCRP was independently predictive of increase in mIMT by 0.06 mm (95%CI [0.01 0.12], P=0.017). Hyperlipidemia and diabetes accounted for IMT increase by 0.56 mm (95%CI [0.04 - 1.08], P=0.037) and 0.53 mm (95%CI [0.01- 1.05], P=0.046) respectively. CONCLUSIONS: This study demonstrated that systemic oxidative stress strongly accelerates secondary progression of carotid atherosclerosis in patients with established ischemic stroke, independent of and above all conventional risk factors including systemic inflammation. This suggests that effective reduction of oxidative stress should be a major therapeutic target in patients at the advanced cardiovascular continuum.
DescriptionPoster Session 4. Epidemiology and public health - Topic: Stroke
This journal suppl. caontin EuroPRevent Congress Abstracts May 2010
Persistent Identifierhttp://hdl.handle.net/10722/125984
ISSN
2013 Impact Factor: 3.691

 

DC FieldValueLanguage
dc.contributor.authorChan, YHen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-10-31T12:03:17Z-
dc.date.available2010-10-31T12:03:17Z-
dc.date.issued2010en_HK
dc.identifier.citationEuroPRevent 2010, Prague, Czech Republic, 5-7 May 2010. In European Journal of Cardiovascular Prevention & Rehabilitation, 2010, v. 17 n. 2, suppl., p. S99, abstract P480en_HK
dc.identifier.issn1741-8267-
dc.identifier.urihttp://hdl.handle.net/10722/125984-
dc.descriptionPoster Session 4. Epidemiology and public health - Topic: Stroke-
dc.descriptionThis journal suppl. caontin EuroPRevent Congress Abstracts May 2010-
dc.description.abstractBACKGROUND: Both increased oxidative and inflammatory stresses are implicated in atherogenesis. However, little is known about their role in atherosclerotic progression in patients already at the advanced cardiovascular continuum. OBJECTIVE: To investigate the impact of oxidative and inflammatory stress on the progression of carotid atherosclerosis in patients with established ischemic stroke. METHODS: A total of 43 consecutive patients (mean age 65.7 +/- 8.8 years; male 70%) with primary or recurrent ischemic stroke (>6 months) were recruited from our medical outpatient clinics. High resolution ultrasound (Agilent Sonos 5500, Philips, USA) was used to assess burden of carotid atherosclerosis in terms of maximum intima-media thickness (mIMT). Serum malodialdehyde (MDA) and high-sensitivity C-reactive protein (hsCRP) were respectively measured as markers of systemic oxidative and inflammatory stress. RESULTS: These patients showed a mean mIMT of 2.25 +/- 0.98 mm. Serum MDA (Pearson r=0.32, P=0.035) and hsCRP (Pearson r=0.41, P=0.007) were both positively associated with mIMT. Adjusting for potential confounders by multivariate model (age, gender, hypertension, diabetes mellitus, hyperlipidemia, smoking history, use of aspirin/ statins/ antihypertensives and body-mass index), each 1 c,M increase in serum MDA independently predicted increase in mIMT by 0.79mm(95%CI [0.23 1.36], P=0.008). Furthermore, each 1 mg/L increase of hsCRP was independently predictive of increase in mIMT by 0.06 mm (95%CI [0.01 0.12], P=0.017). Hyperlipidemia and diabetes accounted for IMT increase by 0.56 mm (95%CI [0.04 - 1.08], P=0.037) and 0.53 mm (95%CI [0.01- 1.05], P=0.046) respectively. CONCLUSIONS: This study demonstrated that systemic oxidative stress strongly accelerates secondary progression of carotid atherosclerosis in patients with established ischemic stroke, independent of and above all conventional risk factors including systemic inflammation. This suggests that effective reduction of oxidative stress should be a major therapeutic target in patients at the advanced cardiovascular continuum.-
dc.languageengen_HK
dc.publisherSage Publications Ltd. The Journal's web site is located at http://cpr.sagepub.com/en_HK
dc.relation.ispartofEuropean Journal of Cardiovascular Prevention & Rehabilitation-
dc.rightsEuropean Journal of Cardiovascular Prevention & Rehabilitation. Copyright © Sage Publications Ltd.-
dc.subjectMedical sciences-
dc.subjectCardiovascular diseases-
dc.titleHeightened systemic oxidative stress critically accelerates worsening carotid atherosclerosis in patients with ischemic strokeen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, YH: chanwill@hku.hken_HK
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH: khkyiu@hku.hken_HK
dc.identifier.emailLi, SW: swan_li@hotmail.comen_HK
dc.identifier.emailTam, S: stam@hkucc.hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hku.hken_HK
dc.identifier.emailLau, CP: cplau@hku.hken_HK
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.authorityChan, YH=rp01313en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.hkuros179885en_HK
dc.identifier.hkuros182907-
dc.identifier.volume17-
dc.identifier.issue2 suppl.-
dc.identifier.spageS99, abstract P480-
dc.identifier.epageS99, abstract P480-
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 130712-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats