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Conference Paper: Early detection of neurodegeneration in brain ischemia by manganese-enhanced MRI

TitleEarly detection of neurodegeneration in brain ischemia by manganese-enhanced MRI
Authors
Issue Date2008
PublisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
Citation
The 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) 2008, Vancouver, BC., 20-25 August 2008. in Proceedings of the 30th EMBS, 2008, p. 3884-3887 How to Cite?
AbstractThis study aims to employ in vivo manganese-enhanced MRI (MEMRI) to detect neurodegenerative changes in two models of brain ischemia, photothrombotic cortical injury (PCI) and transient middle cerebral artery occlusion (MCAO) in rodents. After systemic Mn 2+ injection to both ischemic models, a close pattern of Tl-weighted hyperintensity was observed throughout different brain regions in comparison to the distribution of GFAP, MnSOD and GS immunoreactivities, whereby conventional MRI could hardly detect such. In addition, the infarct volumes in the posterior parts of the brain had significantly reduced after Mn 2+ injection to the MCAO model. It is suggested that exogenous Mn 2+ injection may provide enhanced MEMRI detection of oxidative stress and gliosis early after brain ischemia. Manganese may also mediate infarctions at remote brain regions in transient focal cerebral ischemia before delayed secondary damage takes place. © 2008 IEEE.
Persistent Identifierhttp://hdl.handle.net/10722/125832
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorCai, KXen_HK
dc.contributor.authorSu, HXen_HK
dc.contributor.authorHung, VKen_HK
dc.contributor.authorCheung, MMen_HK
dc.contributor.authorChiu, CTen_HK
dc.contributor.authorGuo, Hen_HK
dc.contributor.authorJian, Yen_HK
dc.contributor.authorChung, SKen_HK
dc.contributor.authorWu, WTen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-10-31T11:54:26Z-
dc.date.available2010-10-31T11:54:26Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) 2008, Vancouver, BC., 20-25 August 2008. in Proceedings of the 30th EMBS, 2008, p. 3884-3887en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/125832-
dc.description.abstractThis study aims to employ in vivo manganese-enhanced MRI (MEMRI) to detect neurodegenerative changes in two models of brain ischemia, photothrombotic cortical injury (PCI) and transient middle cerebral artery occlusion (MCAO) in rodents. After systemic Mn 2+ injection to both ischemic models, a close pattern of Tl-weighted hyperintensity was observed throughout different brain regions in comparison to the distribution of GFAP, MnSOD and GS immunoreactivities, whereby conventional MRI could hardly detect such. In addition, the infarct volumes in the posterior parts of the brain had significantly reduced after Mn 2+ injection to the MCAO model. It is suggested that exogenous Mn 2+ injection may provide enhanced MEMRI detection of oxidative stress and gliosis early after brain ischemia. Manganese may also mediate infarctions at remote brain regions in transient focal cerebral ischemia before delayed secondary damage takes place. © 2008 IEEE.en_HK
dc.languageengen_HK
dc.publisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269-
dc.relation.ispartofProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2008en_HK
dc.rightsIEEE Engineering in Medicine and Biology Society. Conference Proceedings. Copyright © IEEE.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rights©2008 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.subject.meshAlgorithmsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBrain - pathologyen_HK
dc.subject.meshBrain Infarction - diagnosis - pathologyen_HK
dc.subject.meshBrain Ischemia - diagnosis - pathologyen_HK
dc.subject.meshData Interpretation, Statisticalen_HK
dc.subject.meshMagnetic Resonance Imaging - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshManganese - pharmacologyen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshModels, Statisticalen_HK
dc.subject.meshNeurodegenerative Diseases - diagnosis - pathologyen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleEarly detection of neurodegeneration in brain ischemia by manganese-enhanced MRIen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=3884&epage=3887&date=2008&atitle=Early+detection+of+neurodegeneration+in+brain+ischemia+by+manganese-enhanced+MRI-
dc.identifier.emailChung, SK:skchung@hkucc.hku.hken_HK
dc.identifier.emailWu, WT:wtwu@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.identifier.authorityWu, WT=rp00419en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1109/IEMBS.2008.4650058-
dc.identifier.pmid19163561en_HK
dc.identifier.scopuseid_2-s2.0-61849127333en_HK
dc.identifier.hkuros182869en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61849127333&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2008en_HK
dc.identifier.spage3884en_HK
dc.identifier.epage3887en_HK
dc.publisher.placeUnited Statesen_HK
dc.description.otherThe 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) 2008, Vancouver, BC., 20-25 August 2008. in Proceedings of the 30th EMBS, 2008, p. 3884-3887-
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridCai, KX=26321372500en_HK
dc.identifier.scopusauthoridSu, HX=16317750200en_HK
dc.identifier.scopusauthoridHung, VK=55112576200en_HK
dc.identifier.scopusauthoridCheung, MM=24333907800en_HK
dc.identifier.scopusauthoridChiu, CT=26535697200en_HK
dc.identifier.scopusauthoridGuo, H=12774450700en_HK
dc.identifier.scopusauthoridJian, Y=16030867600en_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK
dc.identifier.scopusauthoridWu, WT=7407081122en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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