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Article: Obesity, high-sensitive C-reactive protein and snoring in older Chinese: The Guangzhou Biobank Cohort Study

TitleObesity, high-sensitive C-reactive protein and snoring in older Chinese: The Guangzhou Biobank Cohort Study
Authors
KeywordsChinese
High-sensitive C-reactive protein
Obesity
Snoring
Issue Date2010
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
Citation
Respiratory Medicine, 2010, v. 104 n. 11, p. 1750-1756 How to Cite?
AbstractBackground: abitual snoring and elevated high-sensitive C-reactive protein (HsCRP) have both been associated with increased risk of cardiovascular disease. However, snoring and HsCRP are elevated in obese states which may thus be the primary determinant of both. We therefore investigated whether snoring may mediate the increased vascular risk directly through increased inflammation as indicated by HsCRP levels or if other determinants predominated in a large older Chinese population. Methods: A total of 2508 males and 5709 females aged 50-85 years received a medical check-up including measurement of blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and HsCRP. Information on self-reported snoring status was collected by standardized interview. Results: The age-adjusted geometric mean HsCRP concentrations increased significantly with higher snoring frequency in both genders (linear trend, p = 0.02 for men and p < 0.001 for women), but the association was no longer significant after controlling for waist and BMI. Furthermore, HsCRP levels were not significantly associated with snoring frequency groups stratified by BMI/waist quintiles in both genders, except for the 4th waist quintile in men. No interaction was observed between snoring and BMI/waist on HsCRP levels. The multivariate analysis showed that, in both genders, obesity, but not HsCRP, was associated with snoring. Conclusions: Our results showed that snoring frequency did not have an independent effect on inflammation after adjusting for adiposity, and may thus contribute to vascular disease through alternative mechanisms. © 2010 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/125620
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.396
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLao, XQen_HK
dc.contributor.authorNeil Thomas, Gen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorZhang, WSen_HK
dc.contributor.authorAdab, Pen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorCheng, KKen_HK
dc.date.accessioned2010-10-31T11:41:54Z-
dc.date.available2010-10-31T11:41:54Z-
dc.date.issued2010en_HK
dc.identifier.citationRespiratory Medicine, 2010, v. 104 n. 11, p. 1750-1756en_HK
dc.identifier.issn0954-6111en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125620-
dc.description.abstractBackground: abitual snoring and elevated high-sensitive C-reactive protein (HsCRP) have both been associated with increased risk of cardiovascular disease. However, snoring and HsCRP are elevated in obese states which may thus be the primary determinant of both. We therefore investigated whether snoring may mediate the increased vascular risk directly through increased inflammation as indicated by HsCRP levels or if other determinants predominated in a large older Chinese population. Methods: A total of 2508 males and 5709 females aged 50-85 years received a medical check-up including measurement of blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and HsCRP. Information on self-reported snoring status was collected by standardized interview. Results: The age-adjusted geometric mean HsCRP concentrations increased significantly with higher snoring frequency in both genders (linear trend, p = 0.02 for men and p < 0.001 for women), but the association was no longer significant after controlling for waist and BMI. Furthermore, HsCRP levels were not significantly associated with snoring frequency groups stratified by BMI/waist quintiles in both genders, except for the 4th waist quintile in men. No interaction was observed between snoring and BMI/waist on HsCRP levels. The multivariate analysis showed that, in both genders, obesity, but not HsCRP, was associated with snoring. Conclusions: Our results showed that snoring frequency did not have an independent effect on inflammation after adjusting for adiposity, and may thus contribute to vascular disease through alternative mechanisms. © 2010 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmeden_HK
dc.relation.ispartofRespiratory Medicineen_HK
dc.subjectChineseen_HK
dc.subjectHigh-sensitive C-reactive proteinen_HK
dc.subjectObesityen_HK
dc.subjectSnoringen_HK
dc.subject.meshAged, 80 and over-
dc.subject.meshC-Reactive Protein - metabolism-
dc.subject.meshCardiovascular Diseases - epidemiology - metabolism - physiopathology-
dc.subject.meshObesity - epidemiology - metabolism - physiopathology-
dc.subject.meshSnoring - epidemiology - metabolism - physiopathology-
dc.titleObesity, high-sensitive C-reactive protein and snoring in older Chinese: The Guangzhou Biobank Cohort Studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0954-6111&volume=104&issue=11&spage=1750&epage=1756&date=2010&atitle=Obesity,+high-sensitive+C-reactive+protein+and+snoring+in+older+Chinese:+The+Guangzhou+Biobank+Cohort+Studyen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.rmed.2010.06.003en_HK
dc.identifier.pmid20587368-
dc.identifier.scopuseid_2-s2.0-77957119257en_HK
dc.identifier.hkuros183027en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957119257&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1750en_HK
dc.identifier.epage1756en_HK
dc.identifier.isiWOS:000283900400021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLao, XQ=14031637000en_HK
dc.identifier.scopusauthoridNeil Thomas, G=23568357900en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridZhang, WS=13410704100en_HK
dc.identifier.scopusauthoridAdab, P=6601949045en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK

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