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Article: Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease

TitleDietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease
Authors
KeywordsEndothelial progenitor cells
Isoflavone
Phytoestrogen
Vascular function
Issue Date2011
PublisherSage Publications Ltd. The Journal's web site is located at http://cpr.sagepub.com/
Citation
European Journal Of Cardiovascular Prevention And Rehabilitation, 2011, v. 18 n. 3, p. 360-368 How to Cite?
Abstract
Endogenous estrogen is known to positively influence the level and functionality of endothelial progenitor cells (EPC). However, the effect of phytoestrogen on EPC is unknown. Isoflavone is a major component of phytoestrogen. This study aims to investigate if the intake of isoflavone has any impact on the circulating level of EPC. We studied 102 consecutive patients (mean age: 66.5±9.5 years, 78% male, all female post-menopausal) with cardiovascular disease (atherothrombotic stroke 62%, coronary artery disease 38%). Circulating levels of CD133 + EPC were determined by flow cytometry. Non-invasive pulse wave velocity (PWV) was measured. Long-term intake of isoflavone was determined by a validated food frequency questionnaire. Isoflavone intake was positively associated with circulating CD133 + EPC (r=0.31, p=0.001). Patients with circulating CD133 + EPC <10th percentile had significantly lower isoflavone intake than patients with CD133 +EPC≥10th percentile (4.6±3.7 mg/day versus 19.3±30.2 mg/day, p<0.001). A significant overall linear trend of circulating EPC across increasing tertiles of isoflavone intake was observed (p=0.004). Adjusted for potential confounders, increased isoflavone intake from the 1st to the 3rd tertile independently predicted increased circulating CD133 + EPC level by 221 cells/μl (95%CI: 71.4 to 369.8, relative increase 160%, p=0.004). Gender was not a significant factor (p>0.05). Furthermore, circulating CD133 + EPC <10th percentile was independently predictive of increased PWV by 261.7 cm/s (95% CI: 37.1 to 486.2, p=0.024). The study demonstrated that circulating EPC increased by more than one fold in patients with cardiovascular disease who had higher intake of isoflavone, suggesting that isoflavone may confer vascular protection through enhanced endothelial repair. © The European Society of Cardiology 2011.
Persistent Identifierhttp://hdl.handle.net/10722/125613
ISSN
2013 Impact Factor: 3.691
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong2008-07176179
2009-07176063
Sun Chieh Yeh Heart Foundation
Funding Information:

This work was supported by the CRCG Small Project Funding of University of Hong Kong (grant number 2008-07176179 and 2009-07176063) and Sun Chieh Yeh Heart Foundation.

References

 

Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong
  4. Tung Wah Hospital
DC FieldValueLanguage
dc.contributor.authorChan, YHen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLau, KKen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorLi, SWen_HK
dc.contributor.authorChan, HTen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-10-31T11:41:31Z-
dc.date.available2010-10-31T11:41:31Z-
dc.date.issued2011en_HK
dc.identifier.citationEuropean Journal Of Cardiovascular Prevention And Rehabilitation, 2011, v. 18 n. 3, p. 360-368en_HK
dc.identifier.issn1741-8267en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125613-
dc.description.abstractEndogenous estrogen is known to positively influence the level and functionality of endothelial progenitor cells (EPC). However, the effect of phytoestrogen on EPC is unknown. Isoflavone is a major component of phytoestrogen. This study aims to investigate if the intake of isoflavone has any impact on the circulating level of EPC. We studied 102 consecutive patients (mean age: 66.5±9.5 years, 78% male, all female post-menopausal) with cardiovascular disease (atherothrombotic stroke 62%, coronary artery disease 38%). Circulating levels of CD133 + EPC were determined by flow cytometry. Non-invasive pulse wave velocity (PWV) was measured. Long-term intake of isoflavone was determined by a validated food frequency questionnaire. Isoflavone intake was positively associated with circulating CD133 + EPC (r=0.31, p=0.001). Patients with circulating CD133 + EPC <10th percentile had significantly lower isoflavone intake than patients with CD133 +EPC≥10th percentile (4.6±3.7 mg/day versus 19.3±30.2 mg/day, p<0.001). A significant overall linear trend of circulating EPC across increasing tertiles of isoflavone intake was observed (p=0.004). Adjusted for potential confounders, increased isoflavone intake from the 1st to the 3rd tertile independently predicted increased circulating CD133 + EPC level by 221 cells/μl (95%CI: 71.4 to 369.8, relative increase 160%, p=0.004). Gender was not a significant factor (p>0.05). Furthermore, circulating CD133 + EPC <10th percentile was independently predictive of increased PWV by 261.7 cm/s (95% CI: 37.1 to 486.2, p=0.024). The study demonstrated that circulating EPC increased by more than one fold in patients with cardiovascular disease who had higher intake of isoflavone, suggesting that isoflavone may confer vascular protection through enhanced endothelial repair. © The European Society of Cardiology 2011.en_HK
dc.languageengen_HK
dc.publisherSage Publications Ltd. The Journal's web site is located at http://cpr.sagepub.com/en_HK
dc.relation.ispartofEuropean Journal of Cardiovascular Prevention and Rehabilitationen_HK
dc.subjectEndothelial progenitor cellsen_HK
dc.subjectIsoflavoneen_HK
dc.subjectPhytoestrogenen_HK
dc.subjectVascular functionen_HK
dc.subject.meshAgeden_HK
dc.subject.meshCardiovascular Diseases - blood - diet therapy - prevention & controlen_HK
dc.subject.meshDietary Supplementsen_HK
dc.subject.meshEndothelial Cells - cytology - physiologyen_HK
dc.subject.meshEndothelium, Vascular - cytology - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFlow Cytometryen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPhytoestrogens - administration & dosageen_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshStem Cells - physiologyen_HK
dc.titleDietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1741-8267&volume=&spage=&epage=&date=2011&atitle=Dietary+intake+of+phytoestrogen+is+associated+with+increased+circulating+endothelial+progenitor+cells+in+patients+with+cardiovascular+disease-
dc.identifier.emailChan, YH:chanwill@hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLau, KK:gkklau@hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityChan, YH=rp01313en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLau, KK=rp01499en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/1741826710389385en_HK
dc.identifier.pmid21450646en_HK
dc.identifier.scopuseid_2-s2.0-79959245865en_HK
dc.identifier.hkuros179881en_HK
dc.identifier.hkuros198032-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79959245865&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue3en_HK
dc.identifier.spage360en_HK
dc.identifier.epage368en_HK
dc.identifier.eissn2047-4881-
dc.identifier.isiWOS:000291026100002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, YH=22633700600en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLau, KK=22635159600en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridLi, SW=13807028100en_HK
dc.identifier.scopusauthoridChan, HT=22633582100en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

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