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Article: Translational potential of human embryonic and induced pluripotent stem cells for myocardial repair: Insights from experimental models

TitleTranslational potential of human embryonic and induced pluripotent stem cells for myocardial repair: Insights from experimental models
Authors
KeywordsCardiomyocytes
Human embryonic stem cells
Induced pluripotent stem cells
Issue Date2010
PublisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com
Citation
Thrombosis And Haemostasis, 2010, v. 104 n. 1, p. 30-38 How to Cite?
AbstractHeart diseases have been a major cause of death worldwide, including developed countries. Indeed, loss of non-regenerative, terminally differentiated cardiomyocytes (CMs) due to aging or diseases is irreversible. Current therapeutic regimes are palliative in nature, and in the case of end-stage heart failure, transplantation remains the last resort. However, this option is significantly hampered by a severe shortage of donor cells and organs. Human embryonic stem cells (hESCs) can self-renew while maintaining their pluripotency to differentiate into all cell types. More recently, direct reprogramming of adult somatic cells to become pluripotent hES-like cells (a.k.a. induced pluripotent stem cells or iPSCs) has been achieved. The availability of hESCs and iPSCs, and their successful differentiation into genuine human heart cells have enabled researchers to gain novel insights into the early development of the human heart as well as to pursue the revolutionary paradigm of heart regeneration. Here we review our current knowledge of hESC-/iPSC-derived CMs in the context of two fundamental operating principles of CMs (i.e. electrophysiology and Ca2+-handling), the resultant limitations and potential solutions in relation to their translation into clinical (bioartificial pacemaker, myocardial repair) and other applications (e.g. as models for human heart disease and cardiotoxicity screening). © Schattauer 2010.
Persistent Identifierhttp://hdl.handle.net/10722/125564
ISSN
2015 Impact Factor: 5.255
2015 SCImago Journal Rankings: 2.089
ISI Accession Number ID
Funding AgencyGrant Number
NIHR01 HL72857
CC Wong Stem Cell Foundation
University Development Fund
Funding Information:

This work was supported by grants from the NIH - R01 HL72857 (to R.A.L.), the CC Wong Stem Cell Foundation Fund (to R.A.L.) and the University Development Fund (to C-W.K. and R.A.L.).

References

 

DC FieldValueLanguage
dc.contributor.authorKong, CWen_HK
dc.contributor.authorAkar, FGen_HK
dc.contributor.authorLi, RAen_HK
dc.date.accessioned2010-10-31T11:38:32Z-
dc.date.available2010-10-31T11:38:32Z-
dc.date.issued2010en_HK
dc.identifier.citationThrombosis And Haemostasis, 2010, v. 104 n. 1, p. 30-38en_HK
dc.identifier.issn0340-6245en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125564-
dc.description.abstractHeart diseases have been a major cause of death worldwide, including developed countries. Indeed, loss of non-regenerative, terminally differentiated cardiomyocytes (CMs) due to aging or diseases is irreversible. Current therapeutic regimes are palliative in nature, and in the case of end-stage heart failure, transplantation remains the last resort. However, this option is significantly hampered by a severe shortage of donor cells and organs. Human embryonic stem cells (hESCs) can self-renew while maintaining their pluripotency to differentiate into all cell types. More recently, direct reprogramming of adult somatic cells to become pluripotent hES-like cells (a.k.a. induced pluripotent stem cells or iPSCs) has been achieved. The availability of hESCs and iPSCs, and their successful differentiation into genuine human heart cells have enabled researchers to gain novel insights into the early development of the human heart as well as to pursue the revolutionary paradigm of heart regeneration. Here we review our current knowledge of hESC-/iPSC-derived CMs in the context of two fundamental operating principles of CMs (i.e. electrophysiology and Ca2+-handling), the resultant limitations and potential solutions in relation to their translation into clinical (bioartificial pacemaker, myocardial repair) and other applications (e.g. as models for human heart disease and cardiotoxicity screening). © Schattauer 2010.en_HK
dc.languageengen_HK
dc.publisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.comen_HK
dc.relation.ispartofThrombosis and Haemostasisen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCardiomyocytesen_HK
dc.subjectHuman embryonic stem cellsen_HK
dc.subjectInduced pluripotent stem cellsen_HK
dc.subject.meshCardiovascular Diseases - pathology - physiopathology - therapy-
dc.subject.meshEmbryonic Stem Cells - metabolism - pathology-
dc.subject.meshInduced Pluripotent Stem Cells - metabolism - pathology-
dc.subject.meshMyocardium - metabolism - pathology-
dc.subject.meshStem Cell Transplantation-
dc.titleTranslational potential of human embryonic and induced pluripotent stem cells for myocardial repair: Insights from experimental modelsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0340-6245&volume=104&issue=1&spage=30&epage=38&date=2010&atitle=Translational+potential+of+human+embryonic+and+induced+pluripotent+stem+cells+for+myocardial+repair:+insights+from+experimental+models-
dc.identifier.emailKong, CW:marcokong@hku.hken_HK
dc.identifier.emailLi, RA:ronaldli@hkucc.hku.hken_HK
dc.identifier.authorityKong, CW=rp01563en_HK
dc.identifier.authorityLi, RA=rp01352en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1160/TH10-03-0189en_HK
dc.identifier.pmid20539906-
dc.identifier.scopuseid_2-s2.0-77954356399en_HK
dc.identifier.hkuros175073en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954356399&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume104en_HK
dc.identifier.issue1en_HK
dc.identifier.spage30en_HK
dc.identifier.epage38en_HK
dc.identifier.isiWOS:000280298300006-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridKong, CW=36784634200en_HK
dc.identifier.scopusauthoridAkar, FG=6701446552en_HK
dc.identifier.scopusauthoridLi, RA=7404724466en_HK

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