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Article: Acute infection of chinese macaques by a CCR5-tropic SHIV carrying a primary HIV-1 subtype B' envelope

TitleAcute infection of chinese macaques by a CCR5-tropic SHIV carrying a primary HIV-1 subtype B' envelope
Authors
KeywordsAcute infection
Animal model
Chinese macaques
SHIV
Subtype B'
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.com
Citation
Journal Of Acquired Immune Deficiency Syndromes, 2010, v. 53 n. 3, p. 285-291 How to Cite?
AbstractThe increasing prevalence of HIV-1 subtype B' in China and Southeast Asia calls for efforts to develop a relevant animal model to study viral transmission and pathogenesis. Because there are significant differences between subtype B' HIV-1 and other chimeric simian/human immunodeficiency viru (SHIVs) in the env gene, a novel SHIV, designated SHIV B'WHU, was generated by replacing counterparts of SHIVSF33 with tat/rev/vpu/env genes derived from a primary, CCR5-tropic, subtype B' HIV-1 strain of a Chinese patient. SHIV B'WHU was able to replicate in rhesus peripheral blood mononuclear cells and used CCR5 as its major coreceptor. Moreover, after serial passages in Chinese macaques, the in vivo infectivity of SHIV B' WHU was enhanced, yet no significant sequence changes were found in viral envelopes, and the virus did not change its CCR5-tropism. CD4 T-cell loss, however, was found in the intraepithelial lymphocytes of small intestines of infected macaques. Our findings have implications in understanding the early pathogenesis of SHIV B' WHU in Chinese macaques. Copyright © 2010 by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/125559
ISSN
2015 Impact Factor: 3.806
2015 SCImago Journal Rankings: 2.434
ISI Accession Number ID
Funding AgencyGrant Number
National Basic Research Program of China2006CB504208
National Science and Technology2008ZX10001-011
2008ZX10001-015
Hong KongHK-RGC762208
HK-RGC762209
University of Hong Kong
Funding Information:

Supported by the National Basic Research Program of China (the 973 project 2006CB504208), the National Science and Technology Major Project 2008ZX10001-011 and 2008ZX10001-015, Hong Kong research grant council (HK-RGC762208 and HK-RGC762209 to ZC), and the University Development Fund of the University of Hong Kong to its AIDS Institute.

References

 

DC FieldValueLanguage
dc.contributor.authorWang, Hen_HK
dc.contributor.authorZhuang, Ken_HK
dc.contributor.authorLiu, Len_HK
dc.contributor.authorTang, Zen_HK
dc.contributor.authorTang, Jen_HK
dc.contributor.authorTien, Pen_HK
dc.contributor.authorZhang, Len_HK
dc.contributor.authorChen, Zen_HK
dc.date.accessioned2010-10-31T11:38:15Z-
dc.date.available2010-10-31T11:38:15Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Acquired Immune Deficiency Syndromes, 2010, v. 53 n. 3, p. 285-291en_HK
dc.identifier.issn1525-4135en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125559-
dc.description.abstractThe increasing prevalence of HIV-1 subtype B' in China and Southeast Asia calls for efforts to develop a relevant animal model to study viral transmission and pathogenesis. Because there are significant differences between subtype B' HIV-1 and other chimeric simian/human immunodeficiency viru (SHIVs) in the env gene, a novel SHIV, designated SHIV B'WHU, was generated by replacing counterparts of SHIVSF33 with tat/rev/vpu/env genes derived from a primary, CCR5-tropic, subtype B' HIV-1 strain of a Chinese patient. SHIV B'WHU was able to replicate in rhesus peripheral blood mononuclear cells and used CCR5 as its major coreceptor. Moreover, after serial passages in Chinese macaques, the in vivo infectivity of SHIV B' WHU was enhanced, yet no significant sequence changes were found in viral envelopes, and the virus did not change its CCR5-tropism. CD4 T-cell loss, however, was found in the intraepithelial lymphocytes of small intestines of infected macaques. Our findings have implications in understanding the early pathogenesis of SHIV B' WHU in Chinese macaques. Copyright © 2010 by Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jaids.comen_HK
dc.relation.ispartofJournal of Acquired Immune Deficiency Syndromesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is a non-final version of an article published in final form in J A I D S, 2010, v. 53 n. 3, p. 285-291-
dc.subjectAcute infectionen_HK
dc.subjectAnimal modelen_HK
dc.subjectChinese macaquesen_HK
dc.subjectSHIVen_HK
dc.subjectSubtype B'en_HK
dc.subject.meshDisease Models, Animal-
dc.subject.meshHIV-1 - genetics-
dc.subject.meshReceptors, CCR5 - physiology-
dc.subject.meshReceptors, Virus - physiology-
dc.subject.meshSimian Acquired Immunodeficiency Syndrome - virology-
dc.titleAcute infection of chinese macaques by a CCR5-tropic SHIV carrying a primary HIV-1 subtype B' envelopeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1525-4135&volume=53&issue=3&spage=285&epage=291&date=2010&atitle=Acute+infection+of+Chinese+macaques+by+a+CCR5-tropic+SHIV+carrying+a+primary+HIV-1+subtype+B’+envelope-
dc.identifier.emailLiu, L: liuli71@hkucc.hku.hken_HK
dc.identifier.emailChen, Z: zchenai@hku.hken_HK
dc.identifier.authorityLiu, L=rp00268en_HK
dc.identifier.authorityChen, Z=rp00243en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1097/QAI.0b013e3181cc4f4aen_HK
dc.identifier.pmid20051873-
dc.identifier.scopuseid_2-s2.0-77649205069en_HK
dc.identifier.hkuros181674en_HK
dc.identifier.hkuros175960-
dc.identifier.hkuros190680-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77649205069&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage285en_HK
dc.identifier.epage291en_HK
dc.identifier.isiWOS:000275324500002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, H=8724886600en_HK
dc.identifier.scopusauthoridZhuang, K=6603626241en_HK
dc.identifier.scopusauthoridLiu, L=35784425200en_HK
dc.identifier.scopusauthoridTang, Z=8224831500en_HK
dc.identifier.scopusauthoridTang, J=35785133700en_HK
dc.identifier.scopusauthoridTien, P=7006421622en_HK
dc.identifier.scopusauthoridZhang, L=8783285300en_HK
dc.identifier.scopusauthoridChen, Z=35271180800en_HK

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