File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Scopus: eid_2-s2.0-77950946460
- PMID: 21348415
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: The development of anti-HIV-1 drugs
Title | The development of anti-HIV-1 drugs |
---|---|
Authors | |
Keywords | HIV-1 AIDS Antiretroviral drug Antiretroviral therapy Highly active antiretroviral therapy |
Issue Date | 2010 |
Publisher | Yaoxue Xuebao. The Journal's web site is located at http://yxxb.periodicals.net.cn/default.html |
Citation | Acta Pharmaceutica Sinica (Yaoxue Xuebao), 2010, v. 45 n. 2, p. 165-176 How to Cite? |
Abstract | Human immunodeficiency virus type 1 (HIV-1) is the causative agent of acquired immunodeficiency disease syndrome (AIDS). After over 26 years of efforts, there is still not a therapeutic cure or an effective vaccine against HIV/AIDS. The clinical management of HIV-1 infected people largely relies on antiretroviral therapy (ART). Although highly active antiretroviral therapy (HAART) has provided an effective way to treat AIDS patients, the huge burden of ART in developing countries, together with the increasing incidence of drug resistant viruses among treated people, calls for continuous efforts for the development of anti-HIV-1 drugs. Currently, four classes of over 30 licensed antiretrovirals (ARVs) and combination regimens of these ARVs are in use clinically including: reverse transcriptase inhibitors (RTIs) (e.g. nucleoside reverse transcriptase inhibitors, NRTIs; and non-nucleoside reverse transcriptase inhibitors, NNRTIs), protease inhibitors (PIs), integrase inhibitors and entry inhibitors (e.g. fusion inhibitors and CCR5 antagonists). Here, we intend to provide updated information of currently available antiretroviral drugs for ART to promote the development of novel anti-HIV-1 drugs. |
Persistent Identifier | http://hdl.handle.net/10722/125553 |
ISSN | 2023 SCImago Journal Rankings: 0.152 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lu, XF | en_HK |
dc.contributor.author | Chen, ZW | en_HK |
dc.date.accessioned | 2010-10-31T11:37:55Z | - |
dc.date.available | 2010-10-31T11:37:55Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Acta Pharmaceutica Sinica (Yaoxue Xuebao), 2010, v. 45 n. 2, p. 165-176 | en_HK |
dc.identifier.issn | 0513-4870 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/125553 | - |
dc.description.abstract | Human immunodeficiency virus type 1 (HIV-1) is the causative agent of acquired immunodeficiency disease syndrome (AIDS). After over 26 years of efforts, there is still not a therapeutic cure or an effective vaccine against HIV/AIDS. The clinical management of HIV-1 infected people largely relies on antiretroviral therapy (ART). Although highly active antiretroviral therapy (HAART) has provided an effective way to treat AIDS patients, the huge burden of ART in developing countries, together with the increasing incidence of drug resistant viruses among treated people, calls for continuous efforts for the development of anti-HIV-1 drugs. Currently, four classes of over 30 licensed antiretrovirals (ARVs) and combination regimens of these ARVs are in use clinically including: reverse transcriptase inhibitors (RTIs) (e.g. nucleoside reverse transcriptase inhibitors, NRTIs; and non-nucleoside reverse transcriptase inhibitors, NNRTIs), protease inhibitors (PIs), integrase inhibitors and entry inhibitors (e.g. fusion inhibitors and CCR5 antagonists). Here, we intend to provide updated information of currently available antiretroviral drugs for ART to promote the development of novel anti-HIV-1 drugs. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Yaoxue Xuebao. The Journal's web site is located at http://yxxb.periodicals.net.cn/default.html | en_HK |
dc.relation.ispartof | Yaoxue Xuebao | en_HK |
dc.subject | HIV-1 | - |
dc.subject | AIDS | - |
dc.subject | Antiretroviral drug | - |
dc.subject | Antiretroviral therapy | - |
dc.subject | Highly active antiretroviral therapy | - |
dc.subject.mesh | Acquired Immunodeficiency Syndrome - drug therapy | en_HK |
dc.subject.mesh | Anti-HIV Agents - chemistry - pharmacology - therapeutic use | en_HK |
dc.subject.mesh | HIV Fusion Inhibitors - chemistry - pharmacology - therapeutic use | en_HK |
dc.subject.mesh | HIV Infections - drug therapy | en_HK |
dc.subject.mesh | HIV Integrase Inhibitors - chemistry - pharmacology - therapeutic use | en_HK |
dc.subject.mesh | HIV Protease Inhibitors - chemistry - pharmacology - therapeutic use | en_HK |
dc.subject.mesh | HIV-1 - drug effects | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Molecular Structure | en_HK |
dc.subject.mesh | Reverse Transcriptase Inhibitors - chemistry - pharmacology - therapeutic use | en_HK |
dc.title | The development of anti-HIV-1 drugs | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0513-4870&volume=45&issue=2&spage=165&epage=176&date=2010&atitle=The+development+of+anti-HIV-1+drugs | - |
dc.identifier.email | Chen, ZW:zchenai@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chen, ZW=rp00243 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 21348415 | - |
dc.identifier.scopus | eid_2-s2.0-77950946460 | en_HK |
dc.identifier.hkuros | 181679 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77950946460&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 45 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 165 | en_HK |
dc.identifier.epage | 176 | en_HK |
dc.publisher.place | China | en_HK |
dc.identifier.scopusauthorid | Lu, XF=35215493700 | en_HK |
dc.identifier.scopusauthorid | Chen, ZW=35271180800 | en_HK |
dc.identifier.issnl | 0513-4870 | - |