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Article: Stable and low prevalence of transmitted HIV type 1 drug resistance despite two decades of antiretroviral therapy in Hong Kong

TitleStable and low prevalence of transmitted HIV type 1 drug resistance despite two decades of antiretroviral therapy in Hong Kong
Authors
Issue Date2010
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aid
Citation
Aids Research And Human Retroviruses, 2010, v. 26 n. 10, p. 1079-1085 How to Cite?
AbstractTransmitted HIV resistance is of both clinical and public health importance. Baseline genotypic resistance testing was performed for HIV-1-infected treatment-naive patients who were newly diagnosed between 2003 and 2007 and attended the government HIV clinic in Hong Kong. International AIDS Society-USA mutation figures and the Stanford resistance interpretation algorithm were used to identify resistance mutations and drug susceptibility, respectively. The pattern and factors associated with resistance were examined. The presence of one or more IAS-USA resistance mutations was found in 26 (3.6%) of 731 patients over the 5-year study period. Overall, protease inhibitor (PI) resistance mutations were most common (16), followed by nucleoside reverse transcriptase inhibitors (NRTIs) (8) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) (3). Resistance to drugs in one, two, and three classes was present in 25 (3.4%), 1 (0.1%), and 0, respectively. Seventy-eight (10.7%) had strains of reduced susceptibility, as predicted by the Stanford algorithm to display at least low-level resistance to one or more drugs of the three classes. Intermediate or high-level resistance was found in 1.6% overall, and in descending order for NRTIs, PIs, and NNRTIs. There was no temporal trend of increase in resistance. Sex between men, Chinese ethnicity, and lower baseline CD4 were associated with harboring resistant strains as elucidated by either method. We conclude that transmitted HIV-1 drug resistance is uncommon in up to two decades of antiretroviral therapy in Hong Kong. The situation has to be continually monitored for any change in significance. Copyright 2010, Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/125548
ISSN
2015 Impact Factor: 1.949
2015 SCImago Journal Rankings: 1.024
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Special Administrative Region GovernmentMSS-099R
155R
Funding Information:

The work was supported by the AIDS Trust Fund of the Hong Kong Special Administrative Region Government (Grant MSS-099R and 155R). The authors are grateful to all staff of the Integrated Treatment Centre for their dedicated care of the patients. The opinions and assertions contained herein are the private views of the authors and do not necessarily reflect those of the Centre for Health Protection, Hong Kong Department of Health.

References

 

DC FieldValueLanguage
dc.contributor.authorWong, KHen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorYam, WCen_HK
dc.contributor.authorChen, JHKen_HK
dc.contributor.authorAlvarezBognar, FRen_HK
dc.contributor.authorChan, KCWen_HK
dc.date.accessioned2010-10-31T11:37:39Z-
dc.date.available2010-10-31T11:37:39Z-
dc.date.issued2010en_HK
dc.identifier.citationAids Research And Human Retroviruses, 2010, v. 26 n. 10, p. 1079-1085en_HK
dc.identifier.issn0889-2229en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125548-
dc.description.abstractTransmitted HIV resistance is of both clinical and public health importance. Baseline genotypic resistance testing was performed for HIV-1-infected treatment-naive patients who were newly diagnosed between 2003 and 2007 and attended the government HIV clinic in Hong Kong. International AIDS Society-USA mutation figures and the Stanford resistance interpretation algorithm were used to identify resistance mutations and drug susceptibility, respectively. The pattern and factors associated with resistance were examined. The presence of one or more IAS-USA resistance mutations was found in 26 (3.6%) of 731 patients over the 5-year study period. Overall, protease inhibitor (PI) resistance mutations were most common (16), followed by nucleoside reverse transcriptase inhibitors (NRTIs) (8) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) (3). Resistance to drugs in one, two, and three classes was present in 25 (3.4%), 1 (0.1%), and 0, respectively. Seventy-eight (10.7%) had strains of reduced susceptibility, as predicted by the Stanford algorithm to display at least low-level resistance to one or more drugs of the three classes. Intermediate or high-level resistance was found in 1.6% overall, and in descending order for NRTIs, PIs, and NNRTIs. There was no temporal trend of increase in resistance. Sex between men, Chinese ethnicity, and lower baseline CD4 were associated with harboring resistant strains as elucidated by either method. We conclude that transmitted HIV-1 drug resistance is uncommon in up to two decades of antiretroviral therapy in Hong Kong. The situation has to be continually monitored for any change in significance. Copyright 2010, Mary Ann Liebert, Inc.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aiden_HK
dc.relation.ispartofAIDS Research and Human Retrovirusesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is a copy of an article published in the [Aids Research And Human Retroviruses] © [2010] [copyright Mary Ann Liebert, Inc.]; [Aids Research And Human Retroviruses] is available online at: http://www.liebertonline.com.-
dc.subject.meshAdult-
dc.subject.meshAntiretroviral Therapy, Highly Active-
dc.subject.meshDrug Resistance, Multiple, Viral-
dc.subject.meshHIV Infections - drug therapy - epidemiology-
dc.subject.meshHIV-1 - drug effects-
dc.titleStable and low prevalence of transmitted HIV type 1 drug resistance despite two decades of antiretroviral therapy in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0889-2229&volume=26&issue=10&spage=1079&epage=1085&date=2010&atitle=Stable+and+low+prevalence+of+transmitted+HIV+type+1+drug+resistance+despite+two+decades+of+antiretroviral+therapy+in+Hong+Kongen_HK
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1089/aid.2009.0272en_HK
dc.identifier.pmid20854206-
dc.identifier.scopuseid_2-s2.0-77958190999en_HK
dc.identifier.hkuros182188en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958190999&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1079en_HK
dc.identifier.epage1085en_HK
dc.identifier.isiWOS:000283044200437-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, KH=37096566900en_HK
dc.identifier.scopusauthoridChan, WK=8707113100en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.scopusauthoridChen, JHK=35085819900en_HK
dc.identifier.scopusauthoridAlvarezBognar, FR=36551915800en_HK
dc.identifier.scopusauthoridChan, KCW=35097079800en_HK

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