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- Publisher Website: 10.1097/SLA.0b013e31816a747a
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- PMID: 18362630
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Article: Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening
Title | Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening |
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Authors | |
Issue Date | 2008 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com |
Citation | Annals Of Surgery, 2008, v. 247 n. 4, p. 666-673 How to Cite? |
Abstract | OBJECTIVE: To evaluate the impact of improved surgical management of hepatocellular carcinoma (HCC) on the survival of patients with screened HCC. SUMMARY BACKGROUND DATA: It is unclear whether the advent of new treatment modalities such as liver transplantation and radiofrequency ablation (RFA) in recent years have improved the long-term survival in patients with HCC detected by screening. METHODS: A prospective database of 1366 patients with known chronic hepatitis B or C virus infection diagnosed with HCC either by screening or symptomatic presentation from January 1991 to December 2004 was reviewed. The long-term survival of HCC patients in the screened and symptomatic groups was compared. The management and survival of patients in two 7-year periods (1991-1997 vs. 1998-2004) were further compared. RESULTS: Long-term survival was significantly better in the screened group than in the symptomatic group (median survival 61.9 vs. 11.5 months, P < 0.001). The proportion of patients with curative treatment increased from 50.5% in the first period to 67.8% in the second period in the screened group, but there was no significant change in the symptomatic group. Improved long-term survival was observed in patients with HCC detected by screening and treated in the second period compared with the first period (median survival 68.5 vs. 38.7 months, P = 0.022), but no significant improvement was observed for symptomatic patients. CONCLUSION: Survival of patients with HCC detected by screening has improved in recent years due to increased chance of curative treatment with the advent of liver transplantation and RFA. © 2008 Lippincott Williams & Wilkins, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/125460 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 2.729 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Chan, ACY | en_HK |
dc.contributor.author | Poon, RTP | en_HK |
dc.contributor.author | Ng, KKC | en_HK |
dc.contributor.author | Lo, CM | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.contributor.author | Wong, J | en_HK |
dc.date.accessioned | 2010-10-31T11:32:39Z | - |
dc.date.available | 2010-10-31T11:32:39Z | - |
dc.date.issued | 2008 | en_HK |
dc.identifier.citation | Annals Of Surgery, 2008, v. 247 n. 4, p. 666-673 | en_HK |
dc.identifier.issn | 0003-4932 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/125460 | - |
dc.description.abstract | OBJECTIVE: To evaluate the impact of improved surgical management of hepatocellular carcinoma (HCC) on the survival of patients with screened HCC. SUMMARY BACKGROUND DATA: It is unclear whether the advent of new treatment modalities such as liver transplantation and radiofrequency ablation (RFA) in recent years have improved the long-term survival in patients with HCC detected by screening. METHODS: A prospective database of 1366 patients with known chronic hepatitis B or C virus infection diagnosed with HCC either by screening or symptomatic presentation from January 1991 to December 2004 was reviewed. The long-term survival of HCC patients in the screened and symptomatic groups was compared. The management and survival of patients in two 7-year periods (1991-1997 vs. 1998-2004) were further compared. RESULTS: Long-term survival was significantly better in the screened group than in the symptomatic group (median survival 61.9 vs. 11.5 months, P < 0.001). The proportion of patients with curative treatment increased from 50.5% in the first period to 67.8% in the second period in the screened group, but there was no significant change in the symptomatic group. Improved long-term survival was observed in patients with HCC detected by screening and treated in the second period compared with the first period (median survival 68.5 vs. 38.7 months, P = 0.022), but no significant improvement was observed for symptomatic patients. CONCLUSION: Survival of patients with HCC detected by screening has improved in recent years due to increased chance of curative treatment with the advent of liver transplantation and RFA. © 2008 Lippincott Williams & Wilkins, Inc. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.annalsofsurgery.com | en_HK |
dc.relation.ispartof | Annals of Surgery | en_HK |
dc.rights | Annals of Surgery. Copyright © Lippincott Williams & Wilkins. | - |
dc.subject.mesh | Adult | - |
dc.subject.mesh | Aged | - |
dc.subject.mesh | Aged, 80 and over | - |
dc.subject.mesh | Carcinoma, Hepatocellular - diagnosis - therapy | - |
dc.subject.mesh | Liver Neoplasms - diagnosis - therapy | - |
dc.title | Changing paradigm in the management of hepatocellular carcinoma improves the survival benefit of early detection by screening | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-4932&volume=247&issue=4&spage=666&epage=673&date=2008&atitle=Changing+paradigm+in+the+management+of+hepatocellular+carcinoma+improves+the+survival+benefit+of+early+detection+by+screening | en_HK |
dc.identifier.email | Chan, ACY: acchan@hku.hk | en_HK |
dc.identifier.email | Poon, RTP: poontp@hku.hk | en_HK |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.email | Wong, J: jwong@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, ACY=rp00310 | en_HK |
dc.identifier.authority | Poon, RTP=rp00446 | en_HK |
dc.identifier.authority | Lo, CM=rp00412 | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.identifier.authority | Wong, J=rp00322 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/SLA.0b013e31816a747a | en_HK |
dc.identifier.pmid | 18362630 | - |
dc.identifier.scopus | eid_2-s2.0-41149096402 | en_HK |
dc.identifier.hkuros | 175043 | en_HK |
dc.identifier.hkuros | 141600 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-41149096402&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 247 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 666 | en_HK |
dc.identifier.epage | 673 | en_HK |
dc.identifier.eissn | 1528-1140 | - |
dc.identifier.isi | WOS:000254546900014 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Chan, ACY=15828849100 | en_HK |
dc.identifier.scopusauthorid | Poon, RTP=7103097223 | en_HK |
dc.identifier.scopusauthorid | Ng, KKC=35248894000 | en_HK |
dc.identifier.scopusauthorid | Lo, CM=7401771672 | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.scopusauthorid | Wong, J=8049324500 | en_HK |
dc.identifier.issnl | 0003-4932 | - |