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Article: Comparison of percutaneous and surgical approaches for radiofrequency ablation of small and medium hepatocellular carcinoma

TitleComparison of percutaneous and surgical approaches for radiofrequency ablation of small and medium hepatocellular carcinoma
Authors
Issue Date2007
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.com
Citation
Archives Of Surgery, 2007, v. 142 n. 12, p. 1136-1143 How to Cite?
AbstractHypothesis: Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) can be performed by percutaneous or surgical approach. Tumor size is an important consideration while deciding the treatment approach. Design: Case series with prospective data collection. Setting: A tertiary referral center. Patients: A total of 228 patients who underwent RFA of small (≤3 cm; n=155) and medium (3.1-5 cm; n=73) HCC by percutaneous or surgical approach. Main Outcome Measures: Complete ablation rate, post-RFA complications, treatment-related mortality, and overall and disease-free survival. Results: In patients with small HCC, the complete ablation rate was 95% with both approaches (P>.99). Complication rate (P<.001) and hospital stay (P<.001) were higher with the surgical approach. One-year and 3-year survival rates were 91% and 71%, respectively, in the percutaneous group, and 89% and 57%, respectively, in the surgical group (P=.30). In patients with medium HCC, the complete ablation rate was similar between the surgical and the percutaneous groups (92% vs 95%; P=.48), and the complication rate was also comparable (P=.17). The 1-year and 3-year survival rates were 92% and 68%, respectively, in the surgical group, significantly superior to the corresponding rates of 81% and 42% in the percutaneous group (P=.03). Conclusions: In patients with small HCC, the percutaneous approach achieved similar tumor control with lower morbidity compared with the surgical approach and should be the preferred approach provided that tumor location is suitable. For medium HCC, the surgical approach seems to achieve better overall survival and may be a preferred option. ©2007 American Medical Association. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/125459
ISSN
2014 Impact Factor: 4.926
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKhan, MRen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorNg, KKen_HK
dc.contributor.authorChan, ACen_HK
dc.contributor.authorYuen, Jen_HK
dc.contributor.authorTung, Hen_HK
dc.contributor.authorTsang, Jen_HK
dc.contributor.authorSheung, TFen_HK
dc.date.accessioned2010-10-31T11:32:36Z-
dc.date.available2010-10-31T11:32:36Z-
dc.date.issued2007en_HK
dc.identifier.citationArchives Of Surgery, 2007, v. 142 n. 12, p. 1136-1143en_HK
dc.identifier.issn0004-0010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125459-
dc.description.abstractHypothesis: Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) can be performed by percutaneous or surgical approach. Tumor size is an important consideration while deciding the treatment approach. Design: Case series with prospective data collection. Setting: A tertiary referral center. Patients: A total of 228 patients who underwent RFA of small (≤3 cm; n=155) and medium (3.1-5 cm; n=73) HCC by percutaneous or surgical approach. Main Outcome Measures: Complete ablation rate, post-RFA complications, treatment-related mortality, and overall and disease-free survival. Results: In patients with small HCC, the complete ablation rate was 95% with both approaches (P>.99). Complication rate (P<.001) and hospital stay (P<.001) were higher with the surgical approach. One-year and 3-year survival rates were 91% and 71%, respectively, in the percutaneous group, and 89% and 57%, respectively, in the surgical group (P=.30). In patients with medium HCC, the complete ablation rate was similar between the surgical and the percutaneous groups (92% vs 95%; P=.48), and the complication rate was also comparable (P=.17). The 1-year and 3-year survival rates were 92% and 68%, respectively, in the surgical group, significantly superior to the corresponding rates of 81% and 42% in the percutaneous group (P=.03). Conclusions: In patients with small HCC, the percutaneous approach achieved similar tumor control with lower morbidity compared with the surgical approach and should be the preferred approach provided that tumor location is suitable. For medium HCC, the surgical approach seems to achieve better overall survival and may be a preferred option. ©2007 American Medical Association. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archsurg.comen_HK
dc.relation.ispartofArchives of Surgeryen_HK
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCarcinoma, Hepatocellular - pathology - therapy-
dc.subject.meshCatheter Ablation - methods-
dc.subject.meshLiver Neoplasms - pathology - therapy-
dc.titleComparison of percutaneous and surgical approaches for radiofrequency ablation of small and medium hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0004-0010&volume=142&issue=12&spage=1136&epage=1143&date=2007&atitle=Comparison+of+percutaneous+and+surgical+approaches+for+radiofrequency+ablation+of+small+and+medium+hepatocellular+carcinomaen_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailChan, AC: acchan@hku.hken_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityChan, AC=rp00310en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1001/archsurg.142.12.1136-
dc.identifier.pmid18086979-
dc.identifier.scopuseid_2-s2.0-37349024086en_HK
dc.identifier.hkuros175041en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37349024086&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume142en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1136en_HK
dc.identifier.epage1143en_HK
dc.identifier.isiWOS:000251685200003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKhan, MR=25644360300en_HK
dc.identifier.scopusauthoridPoon, RTP=7103097223en_HK
dc.identifier.scopusauthoridNg, KK=35248894000en_HK
dc.identifier.scopusauthoridChan, AC=15828849100en_HK
dc.identifier.scopusauthoridYuen, J=7102620431en_HK
dc.identifier.scopusauthoridTung, H=23089742300en_HK
dc.identifier.scopusauthoridTsang, J=9734766500en_HK
dc.identifier.scopusauthoridSheung, TF=6506234707en_HK

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