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Article: Mortalin: a potential target for cancer therapy

TitleMortalin: a potential target for cancer therapy
Authors
KeywordsMortalin
Cancer
p53
Therapy
Issue Date2010
PublisherZhongguo Jiating Yisheng Zazhishe. The Journal's web site is located at http://fzzdyzlzz.periodicals.net.cn/gyjs.asp?ID=6766292
Citation
Journal of Molecular Diagnosis and Therapy, 2010, v. 2 n. 4, p. 217-222 How to Cite?
AbstractThe heat shock protein 70 family member mortalin (mot-2)/mthsp70/PBP74/GRP75 is highly expressed in cancer cells with special perinuclear cellular distribution. As a chaperon protein, mortalin has multiple subcellular localizations and binding partners and its functions involve in mitochondria input, energy generation, intracellular trafficking, and receptor internalization. Most importantly, mortalin contributes to carcinogenesis by sequestrating key tumor suppressor p53 in the cytoplasm and inactive its transcriptional and non-transcriptional apoptotic function. The present article tries to summarize the recent findings on mortalin's role in carcinogenesis and proposes it as a potential target for cancer therapy.
Persistent Identifierhttp://hdl.handle.net/10722/125429
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLu, Wen_HK
dc.contributor.authorLuk, JMCen_HK
dc.date.accessioned2010-10-31T11:30:56Z-
dc.date.available2010-10-31T11:30:56Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal of Molecular Diagnosis and Therapy, 2010, v. 2 n. 4, p. 217-222-
dc.identifier.issn1674-6929-
dc.identifier.urihttp://hdl.handle.net/10722/125429-
dc.description.abstractThe heat shock protein 70 family member mortalin (mot-2)/mthsp70/PBP74/GRP75 is highly expressed in cancer cells with special perinuclear cellular distribution. As a chaperon protein, mortalin has multiple subcellular localizations and binding partners and its functions involve in mitochondria input, energy generation, intracellular trafficking, and receptor internalization. Most importantly, mortalin contributes to carcinogenesis by sequestrating key tumor suppressor p53 in the cytoplasm and inactive its transcriptional and non-transcriptional apoptotic function. The present article tries to summarize the recent findings on mortalin's role in carcinogenesis and proposes it as a potential target for cancer therapy.-
dc.languageengen_HK
dc.publisherZhongguo Jiating Yisheng Zazhishe. The Journal's web site is located at http://fzzdyzlzz.periodicals.net.cn/gyjs.asp?ID=6766292-
dc.relation.ispartofJournal of Molecular Diagnosis and Therapy-
dc.subjectMortalin-
dc.subjectCancer-
dc.subjectp53-
dc.subjectTherapy-
dc.titleMortalin: a potential target for cancer therapyen_HK
dc.typeArticleen_HK
dc.identifier.emailLu, W: h0794120@hku.hken_HK
dc.identifier.emailLuk, JMC: jmluk@hkucc.hku.hken_HK
dc.identifier.authorityLuk, JMC=rp00349en_HK
dc.identifier.hkuros182521en_HK
dc.identifier.volume2en_HK
dc.identifier.issue4en_HK
dc.identifier.spage217en_HK
dc.identifier.epage222en_HK
dc.publisher.placeChina-

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