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Article: Impact of neoadjuvant treatment on total mesorectal excision for ultra-low rectal cancers

TitleImpact of neoadjuvant treatment on total mesorectal excision for ultra-low rectal cancers
Authors
Issue Date2010
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.wjso.com/home
Citation
World Journal Of Surgical Oncology, 2010, v. 8 How to Cite?
AbstractBackground: This study reviewed the impact of pre-operative chemoradiotherapy or post-operative chemotherapy and/or radiotherapy on total mesorectal excision (TME) for ultralow rectal cancers that required either low anterior resection with peranal coloanal anastomosis or abdomino-perineal resection (APR). We examined surgical complications, local recurrence and survival.Methods: Of the 1270 patients who underwent radical resection for rectal cancer from 1994 till 2007, 180 with tumors within 4 cm with either peranal coloanal anastomosis or APR were analyzed. Patients were compared in groups that had surgery only (Group A), pre-operative chemoradiotherapy (Group B), and post-operative therapy (Group C).Results: There were 115 males and the mean age was 65.43 years (range 30-89). APR was performed in 134 patients while 46 had a sphincter-preserving resection with peranal coloanal anastomosis. The mean follow-up period was 52.98 months (range: 0.57 to 178.9). There were 69, 58 and 53 patients in Groups A, B, and C, respectively. Nine patients in Group B could go on to have sphincter-saving rectal resection. The overall peri-operative complication rate was 43.4% in Group A vs. 29.3% in Group B vs. 39.6% in Group C, respectively. The local recurrence rate was significantly lower in Group B (8.6.9% vs. 21.7% in Group A vs. 33.9% in Group C) p < 0.05. The 5-year cancer-specific survival rates for Group A was 49.3%, Group B was 69.9% and Group C was 38.8% (p = 0.14).Conclusion: Pre-operative chemoradiation in low rectal cancer is not associated with a higher incidence of peri-operative complications and its benefits may include reduction local recurrence. © 2010 Lim et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/125420
ISSN
2015 Impact Factor: 1.286
2015 SCImago Journal Rankings: 0.625
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLim, YKen_HK
dc.contributor.authorLaw, WLen_HK
dc.contributor.authorLiu, Ren_HK
dc.contributor.authorPoon, JTCen_HK
dc.contributor.authorFan, JFMen_HK
dc.contributor.authorLo, OSHen_HK
dc.date.accessioned2010-10-31T11:30:25Z-
dc.date.available2010-10-31T11:30:25Z-
dc.date.issued2010en_HK
dc.identifier.citationWorld Journal Of Surgical Oncology, 2010, v. 8en_HK
dc.identifier.issn1477-7819en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125420-
dc.description.abstractBackground: This study reviewed the impact of pre-operative chemoradiotherapy or post-operative chemotherapy and/or radiotherapy on total mesorectal excision (TME) for ultralow rectal cancers that required either low anterior resection with peranal coloanal anastomosis or abdomino-perineal resection (APR). We examined surgical complications, local recurrence and survival.Methods: Of the 1270 patients who underwent radical resection for rectal cancer from 1994 till 2007, 180 with tumors within 4 cm with either peranal coloanal anastomosis or APR were analyzed. Patients were compared in groups that had surgery only (Group A), pre-operative chemoradiotherapy (Group B), and post-operative therapy (Group C).Results: There were 115 males and the mean age was 65.43 years (range 30-89). APR was performed in 134 patients while 46 had a sphincter-preserving resection with peranal coloanal anastomosis. The mean follow-up period was 52.98 months (range: 0.57 to 178.9). There were 69, 58 and 53 patients in Groups A, B, and C, respectively. Nine patients in Group B could go on to have sphincter-saving rectal resection. The overall peri-operative complication rate was 43.4% in Group A vs. 29.3% in Group B vs. 39.6% in Group C, respectively. The local recurrence rate was significantly lower in Group B (8.6.9% vs. 21.7% in Group A vs. 33.9% in Group C) p < 0.05. The 5-year cancer-specific survival rates for Group A was 49.3%, Group B was 69.9% and Group C was 38.8% (p = 0.14).Conclusion: Pre-operative chemoradiation in low rectal cancer is not associated with a higher incidence of peri-operative complications and its benefits may include reduction local recurrence. © 2010 Lim et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.wjso.com/homeen_HK
dc.relation.ispartofWorld Journal of Surgical Oncologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsWorld Journal of Surgical Oncology. Copyright © BioMed Central Ltd.-
dc.subject.meshAdenocarcinoma - drug therapy - pathology - radiotherapy - therapy-
dc.subject.meshAntimetabolites, Antineoplastic - therapeutic use-
dc.subject.meshDigestive System Surgical Procedures-
dc.subject.meshFluorouracil - therapeutic use-
dc.subject.meshNeoadjuvant Therapy-
dc.titleImpact of neoadjuvant treatment on total mesorectal excision for ultra-low rectal cancersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1477-7819&volume=8&issue=23&spage=&epage=&date=2010&atitle=Impact+of+neoadjuvant+treatment+on+total+mesorectal+excision+for+ultra-low+rectal+cancersen_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.emailPoon, JTC: tcjensen@hkucc.hku.hken_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.identifier.authorityPoon, JTC=rp01603en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1477-7819-8-23en_HK
dc.identifier.pmid20346160en_HK
dc.identifier.pmcidPMC2859360-
dc.identifier.scopuseid_2-s2.0-77952310022en_HK
dc.identifier.hkuros175953en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952310022&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue23-
dc.identifier.isiWOS:000277430400001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLim, YK=34973264600en_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.identifier.scopusauthoridLiu, R=15056333400en_HK
dc.identifier.scopusauthoridPoon, JTC=7005903722en_HK
dc.identifier.scopusauthoridFan, JFM=36028123200en_HK
dc.identifier.scopusauthoridLo, OSH=6508168045en_HK
dc.identifier.citeulike6970746-

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