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Article: Metabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B-and T-cell lymphomas

TitleMetabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B-and T-cell lymphomas
Authors
KeywordsNK-cell lymphoma
non-Hodgkin lymphoma
PET/CT
SUV max
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmed.com/
Citation
Clinical Nuclear Medicine, 2010, v. 35 n. 8, p. 571-575 How to Cite?
AbstractPurpose: We aim to compare the metabolic activity by F-18 fluorodeoxy-glucose (FDG) uptake across the various histologic subtypes of non-Hodgkin lymphoma (NHL) in a single center, with particular interest in the natural killer (NK)-cell lymphoma subtype for which literature is scarce because of the rarity of these lymphomas in Western populations. Materials and methods: We retrospectively evaluated the FDG-avidity of pretreatment positron emission tomography-computed tomography scans of 117 consecutive NHL patients by measuring the lesion with the highest maximum standardized uptake value (SUV max) in each patient. Mean SUV max of 4 major groups of NHL; aggressive B-cell (n = 63), indolent B-cell (n = 31), NK-cell (n = 14) and aggressive T-cell lymphoma (n = 9), was compared using one-way analysis of variance. P value <0.05 was considered statistically significant. Results: SUV max (mean ± standard deviation) of NK-cell lymphoma (9.2 ± 4.5) was significantly lower than aggressive B-cell lymphoma (14.1 ± 6.4) (P = 0.013), similar to aggressive T-cell lymphoma (7.6 ± 3.9) and significantly higher than that of indolent B-cell lymphoma (5.3 ± 3.1) (P = 0.039). Conclusion: The metabolic phenotype, characterized by FDG uptake of the various NHL subtypes is described. Although NK-cell lymphomas demonstrate high metabolic activity, SUV max is significantly lower than its aggressive B-cell counterparts. This may reflect the large amount of coagulative necrosis and inflammatory component of the tumor, and the relatively slower tumor growth rate compared with aggressive B-cell lymphomas. © 2010 by Lippincott Williams and Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/125325
ISSN
2014 Impact Factor: 3.931
2013 SCImago Journal Rankings: 0.428
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong, Hong Kong S.A.R., ChinaHKU 766408M
Funding Information:

Supported by RGC GRF grant HKU 766408M from The University of Hong Kong, Hong Kong S.A.R., China.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChan, WKSen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorWong, CYOen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorLeung, AYHen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-10-31T11:24:45Z-
dc.date.available2010-10-31T11:24:45Z-
dc.date.issued2010en_HK
dc.identifier.citationClinical Nuclear Medicine, 2010, v. 35 n. 8, p. 571-575en_HK
dc.identifier.issn0363-9762en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125325-
dc.description.abstractPurpose: We aim to compare the metabolic activity by F-18 fluorodeoxy-glucose (FDG) uptake across the various histologic subtypes of non-Hodgkin lymphoma (NHL) in a single center, with particular interest in the natural killer (NK)-cell lymphoma subtype for which literature is scarce because of the rarity of these lymphomas in Western populations. Materials and methods: We retrospectively evaluated the FDG-avidity of pretreatment positron emission tomography-computed tomography scans of 117 consecutive NHL patients by measuring the lesion with the highest maximum standardized uptake value (SUV max) in each patient. Mean SUV max of 4 major groups of NHL; aggressive B-cell (n = 63), indolent B-cell (n = 31), NK-cell (n = 14) and aggressive T-cell lymphoma (n = 9), was compared using one-way analysis of variance. P value <0.05 was considered statistically significant. Results: SUV max (mean ± standard deviation) of NK-cell lymphoma (9.2 ± 4.5) was significantly lower than aggressive B-cell lymphoma (14.1 ± 6.4) (P = 0.013), similar to aggressive T-cell lymphoma (7.6 ± 3.9) and significantly higher than that of indolent B-cell lymphoma (5.3 ± 3.1) (P = 0.039). Conclusion: The metabolic phenotype, characterized by FDG uptake of the various NHL subtypes is described. Although NK-cell lymphomas demonstrate high metabolic activity, SUV max is significantly lower than its aggressive B-cell counterparts. This may reflect the large amount of coagulative necrosis and inflammatory component of the tumor, and the relatively slower tumor growth rate compared with aggressive B-cell lymphomas. © 2010 by Lippincott Williams and Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmed.com/en_HK
dc.relation.ispartofClinical Nuclear Medicineen_HK
dc.subjectNK-cell lymphomaen_HK
dc.subjectnon-Hodgkin lymphomaen_HK
dc.subjectPET/CTen_HK
dc.subjectSUV maxen_HK
dc.subject.meshFluorodeoxyglucose F18 - diagnostic use-
dc.subject.meshKiller Cells, Natural - metabolism-
dc.subject.meshLymphoma, B-Cell - metabolism - pathology - radionuclide imaging-
dc.subject.meshLymphoma, T-Cell - metabolism - pathology - radionuclide imaging-
dc.subject.meshPositron-Emission Tomography-
dc.titleMetabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B-and T-cell lymphomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0363-9762&volume=35&issue=8&spage=571&epage=575&date=2010&atitle=Metabolic+activity+measured+by+F-18+FDG+PET+in+natural+killer-cell+lymphoma+compared+to+aggressive+B-+and+T-cell+lymphomasen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/RLU.0b013e3181e4dcbfen_HK
dc.identifier.pmid20631501en_HK
dc.identifier.scopuseid_2-s2.0-77955146825en_HK
dc.identifier.hkuros174600en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955146825&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume35en_HK
dc.identifier.issue8en_HK
dc.identifier.spage571en_HK
dc.identifier.epage575en_HK
dc.identifier.isiWOS:000279892100002-
dc.publisher.placeUnited Statesen_HK
dc.relation.project18F-FDG PET-CT in prognostication and response assessment of aggressive mature T-cell and NK-cell lymphomas-
dc.identifier.scopusauthoridChan, WKS=54407898800en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridWong, CYO=24577897800en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK

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