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Article: Metabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B-and T-cell lymphomas
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TitleMetabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B-and T-cell lymphomas
 
AuthorsChan, WKS2
Au, WY2
Wong, CYO1
Liang, R2
Leung, AYH2
Kwong, YL2
Khong, PL2
 
KeywordsNK-cell lymphoma
non-Hodgkin lymphoma
PET/CT
SUV max
 
Issue Date2010
 
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmed.com/
 
CitationClinical Nuclear Medicine, 2010, v. 35 n. 8, p. 571-575 [How to Cite?]
DOI: http://dx.doi.org/10.1097/RLU.0b013e3181e4dcbf
 
AbstractPurpose: We aim to compare the metabolic activity by F-18 fluorodeoxy-glucose (FDG) uptake across the various histologic subtypes of non-Hodgkin lymphoma (NHL) in a single center, with particular interest in the natural killer (NK)-cell lymphoma subtype for which literature is scarce because of the rarity of these lymphomas in Western populations. Materials and methods: We retrospectively evaluated the FDG-avidity of pretreatment positron emission tomography-computed tomography scans of 117 consecutive NHL patients by measuring the lesion with the highest maximum standardized uptake value (SUV max) in each patient. Mean SUV max of 4 major groups of NHL; aggressive B-cell (n = 63), indolent B-cell (n = 31), NK-cell (n = 14) and aggressive T-cell lymphoma (n = 9), was compared using one-way analysis of variance. P value <0.05 was considered statistically significant. Results: SUV max (mean ± standard deviation) of NK-cell lymphoma (9.2 ± 4.5) was significantly lower than aggressive B-cell lymphoma (14.1 ± 6.4) (P = 0.013), similar to aggressive T-cell lymphoma (7.6 ± 3.9) and significantly higher than that of indolent B-cell lymphoma (5.3 ± 3.1) (P = 0.039). Conclusion: The metabolic phenotype, characterized by FDG uptake of the various NHL subtypes is described. Although NK-cell lymphomas demonstrate high metabolic activity, SUV max is significantly lower than its aggressive B-cell counterparts. This may reflect the large amount of coagulative necrosis and inflammatory component of the tumor, and the relatively slower tumor growth rate compared with aggressive B-cell lymphomas. © 2010 by Lippincott Williams and Wilkins.
 
ISSN0363-9762
2012 Impact Factor: 2.955
2012 SCImago Journal Rankings: 0.391
 
DOIhttp://dx.doi.org/10.1097/RLU.0b013e3181e4dcbf
 
ISI Accession Number IDWOS:000279892100002
Funding AgencyGrant Number
University of Hong Kong, Hong Kong S.A.R., ChinaHKU 766408M
Funding Information:

Supported by RGC GRF grant HKU 766408M from The University of Hong Kong, Hong Kong S.A.R., China.

 
ReferencesReferences in Scopus
 
Grants18F-FDG PET-CT in prognostication and response assessment of aggressive mature T-cell and NK-cell lymphomas
 
DC FieldValue
dc.contributor.authorChan, WKS
 
dc.contributor.authorAu, WY
 
dc.contributor.authorWong, CYO
 
dc.contributor.authorLiang, R
 
dc.contributor.authorLeung, AYH
 
dc.contributor.authorKwong, YL
 
dc.contributor.authorKhong, PL
 
dc.date.accessioned2010-10-31T11:24:45Z
 
dc.date.available2010-10-31T11:24:45Z
 
dc.date.issued2010
 
dc.description.abstractPurpose: We aim to compare the metabolic activity by F-18 fluorodeoxy-glucose (FDG) uptake across the various histologic subtypes of non-Hodgkin lymphoma (NHL) in a single center, with particular interest in the natural killer (NK)-cell lymphoma subtype for which literature is scarce because of the rarity of these lymphomas in Western populations. Materials and methods: We retrospectively evaluated the FDG-avidity of pretreatment positron emission tomography-computed tomography scans of 117 consecutive NHL patients by measuring the lesion with the highest maximum standardized uptake value (SUV max) in each patient. Mean SUV max of 4 major groups of NHL; aggressive B-cell (n = 63), indolent B-cell (n = 31), NK-cell (n = 14) and aggressive T-cell lymphoma (n = 9), was compared using one-way analysis of variance. P value <0.05 was considered statistically significant. Results: SUV max (mean ± standard deviation) of NK-cell lymphoma (9.2 ± 4.5) was significantly lower than aggressive B-cell lymphoma (14.1 ± 6.4) (P = 0.013), similar to aggressive T-cell lymphoma (7.6 ± 3.9) and significantly higher than that of indolent B-cell lymphoma (5.3 ± 3.1) (P = 0.039). Conclusion: The metabolic phenotype, characterized by FDG uptake of the various NHL subtypes is described. Although NK-cell lymphomas demonstrate high metabolic activity, SUV max is significantly lower than its aggressive B-cell counterparts. This may reflect the large amount of coagulative necrosis and inflammatory component of the tumor, and the relatively slower tumor growth rate compared with aggressive B-cell lymphomas. © 2010 by Lippincott Williams and Wilkins.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationClinical Nuclear Medicine, 2010, v. 35 n. 8, p. 571-575 [How to Cite?]
DOI: http://dx.doi.org/10.1097/RLU.0b013e3181e4dcbf
 
dc.identifier.doihttp://dx.doi.org/10.1097/RLU.0b013e3181e4dcbf
 
dc.identifier.epage575
 
dc.identifier.hkuros174600
 
dc.identifier.isiWOS:000279892100002
Funding AgencyGrant Number
University of Hong Kong, Hong Kong S.A.R., ChinaHKU 766408M
Funding Information:

Supported by RGC GRF grant HKU 766408M from The University of Hong Kong, Hong Kong S.A.R., China.

 
dc.identifier.issn0363-9762
2012 Impact Factor: 2.955
2012 SCImago Journal Rankings: 0.391
 
dc.identifier.issue8
 
dc.identifier.openurl
 
dc.identifier.pmid20631501
 
dc.identifier.scopuseid_2-s2.0-77955146825
 
dc.identifier.spage571
 
dc.identifier.urihttp://hdl.handle.net/10722/125325
 
dc.identifier.volume35
 
dc.languageeng
 
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.nuclearmed.com/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical Nuclear Medicine
 
dc.relation.project18F-FDG PET-CT in prognostication and response assessment of aggressive mature T-cell and NK-cell lymphomas
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshFluorodeoxyglucose F18 - diagnostic use
 
dc.subject.meshKiller Cells, Natural - metabolism
 
dc.subject.meshLymphoma, B-Cell - metabolism - pathology - radionuclide imaging
 
dc.subject.meshLymphoma, T-Cell - metabolism - pathology - radionuclide imaging
 
dc.subject.meshPositron-Emission Tomography
 
dc.subjectNK-cell lymphoma
 
dc.subjectnon-Hodgkin lymphoma
 
dc.subjectPET/CT
 
dc.subjectSUV max
 
dc.titleMetabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B-and T-cell lymphomas
 
dc.typeArticle
 
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<contributor.author>Leung, AYH</contributor.author>
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Author Affiliations
  1. Oakland University
  2. The University of Hong Kong