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Article: The putative neurodegenerative links between depression and Alzheimer's disease

TitleThe putative neurodegenerative links between depression and Alzheimer's disease
Authors
KeywordsAlzheimer's disease
Brain-derived nerve growth factor
Cortisol
Depression
Neurodegeneration
Neuroinflammation
Issue Date2010
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/pneurobio
Citation
Progress In Neurobiology, 2010, v. 91 n. 4, p. 362-375 How to Cite?
AbstractAlzheimer's disease (AD) is the leading neurodegenerative cause of dementia in the elderly. Thus far, there is no curative treatment for this devastating condition, thereby creating significant social and medical burdens. AD is characterized by progressive cognitive decline along with various neuropsychiatric symptoms, including depression and psychosis.Depression is a common psychiatric disorder affecting individuals across the life span. Although the " monoamine hypothesis" of depression has long been proposed, the pathologies and mechanisms for depressive disorders remain only partially understood. Pharmacotherapies targeting the monoaminergic pathways have been the mainstay in treating depression. Additional therapeutic approaches focusing other pathological mechanisms of depression are currently being explored.Interestingly, a number of proposed mechanisms for depression appear to be similar to those implicated in neurodegenerative diseases, including AD. For example, diminishing neurotrophic factors and neuroinflammation observed in depression are found to be associated with the development of AD. This article first provides a concise review of AD and depression, then discusses the putative links between the two neuropsychiatric conditions. © 2010 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/125317
ISSN
2015 Impact Factor: 13.177
2015 SCImago Journal Rankings: 5.775
ISI Accession Number ID
Funding AgencyGrant Number
HKU Alzheimer's Disease Research Network under University Strategic Research Theme of Healthy Aging
NSFC-RGC Joint Research SchemeNSFC_HKU 707/07M
General Research FundGRF 755206M
761609M
Research Grant Council, HKU Seed Funding for Basic Science Research200911159082
Funding Information:

The work in the Laboratory of Neurodegenerative Diseases is supported by HKU Alzheimer's Disease Research Network under University Strategic Research Theme of Healthy Aging, NSFC-RGC Joint Research Scheme (NSFC_HKU 707/07M), General Research Fund (GRF 755206M & 761609M) by Research Grant Council, HKU Seed Funding for Basic Science Research (200911159082).

References

 

DC FieldValueLanguage
dc.contributor.authorWuwongse, Sen_HK
dc.contributor.authorChang, RCCen_HK
dc.contributor.authorLaw, ACKen_HK
dc.date.accessioned2010-10-31T11:24:18Z-
dc.date.available2010-10-31T11:24:18Z-
dc.date.issued2010en_HK
dc.identifier.citationProgress In Neurobiology, 2010, v. 91 n. 4, p. 362-375en_HK
dc.identifier.issn0301-0082en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125317-
dc.description.abstractAlzheimer's disease (AD) is the leading neurodegenerative cause of dementia in the elderly. Thus far, there is no curative treatment for this devastating condition, thereby creating significant social and medical burdens. AD is characterized by progressive cognitive decline along with various neuropsychiatric symptoms, including depression and psychosis.Depression is a common psychiatric disorder affecting individuals across the life span. Although the " monoamine hypothesis" of depression has long been proposed, the pathologies and mechanisms for depressive disorders remain only partially understood. Pharmacotherapies targeting the monoaminergic pathways have been the mainstay in treating depression. Additional therapeutic approaches focusing other pathological mechanisms of depression are currently being explored.Interestingly, a number of proposed mechanisms for depression appear to be similar to those implicated in neurodegenerative diseases, including AD. For example, diminishing neurotrophic factors and neuroinflammation observed in depression are found to be associated with the development of AD. This article first provides a concise review of AD and depression, then discusses the putative links between the two neuropsychiatric conditions. © 2010 Elsevier Ltd.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/pneurobioen_HK
dc.relation.ispartofProgress in Neurobiologyen_HK
dc.subjectAlzheimer's diseaseen_HK
dc.subjectBrain-derived nerve growth factoren_HK
dc.subjectCortisolen_HK
dc.subjectDepressionen_HK
dc.subjectNeurodegenerationen_HK
dc.subjectNeuroinflammationen_HK
dc.subject.meshAcetylcholine - metabolismen_HK
dc.subject.meshAlzheimer Disease - complications - pathology - therapyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshDepression - etiology - pathologyen_HK
dc.subject.meshGlutamic Acid - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshNerve Degeneration - complications - therapyen_HK
dc.subject.meshNeurons - metabolism - pathologyen_HK
dc.titleThe putative neurodegenerative links between depression and Alzheimer's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0301-0082&volume=91&spage=362&epage=375&date=2010&atitle=The+putative+neurodegenerative+links+between+depression+and+Alzheimer%27s+diseaseen_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.emailLaw, ACK: acklaw@hku.hken_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.identifier.authorityLaw, ACK=rp00262en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pneurobio.2010.04.005en_HK
dc.identifier.pmid20441786-
dc.identifier.scopuseid_2-s2.0-77954179493en_HK
dc.identifier.hkuros178994en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954179493&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue4en_HK
dc.identifier.spage362en_HK
dc.identifier.epage375en_HK
dc.identifier.eissn1873-5118-
dc.identifier.isiWOS:000280321300006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWuwongse, S=36571219000en_HK
dc.identifier.scopusauthoridChang, RCC=7403713410en_HK
dc.identifier.scopusauthoridLaw, ACK=26323772800en_HK
dc.identifier.citeulike7146498-

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