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Article: Maturation of canal-related brainstem neurons in the detection of horizontal angular acceleration in rats

TitleMaturation of canal-related brainstem neurons in the detection of horizontal angular acceleration in rats
Authors
KeywordsC-fos
Canal
Development
Inferior olive
Vestibular nuclei
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248
Citation
Journal Of Comparative Neurology, 2010, v. 518 n. 10, p. 1742-1763 How to Cite?
AbstractWe examined the functional maturation of canal-related brainstem neurons in Sprague-Dawley rats at postnatal day (P) 1 to adult. Conscious animals were subjected to cycles of angular acceleration and deceleration so as to selectively activate hair cells of the horizontal semicircular canals. Brainstem neurons were monitored for c-fos expression by immune-hybridization histochemistry as an indicator of neuronal activation. Fos-immunoreactive canalrelated neurons were identifiable from P4 onwards in the vestibular nucleus and downstream vestibular relay stations, propositus hypoglossal nucleus, and inferior olive. In the vestibular nucleus and prepositus hypoglossal nucleus, the number of canal-related neurons increased progressively with age, reaching the adult level by P21. Those in the inferior olive increased in number from P4to P14 but decreased significantly afterwards until adulthood. The topography was not clear in the vestibular nucleus and pre-positus hypoglossal nucleus. Canal-related neurons in P4 -7 rats were spread throughout the rostrocaudal length of each subnucleus but clusters of canal-related neurons tended to form within specific subnuclei by P21. These were concentrated in the caudal halves of medial and spinal vestibular nuclei and the rostral parts of superior vestibular nucleus and prepositus hypoglossal nucleus. In the inferior olive, the topography was evident early in the course of development. Canal-related neurons were exclusively located in four subnuclei: dorsal medial cell column, dorsal cap, subnucleus A, and subnucleus C, but not in other subnuclei. Taken together, our data revealed the developmental profile of neuronal subpopulations within the horizontal canal system, thus providing an internal neural representation for postnatal coding of horizontal head rotations in spatial perception. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/125298
ISSN
2015 Impact Factor: 3.331
2015 SCImago Journal Rankings: 2.345
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7657/06M
761407M
Funding Information:

Grant sponsor: Hong Kong Research Grants Council; Grant numbers: HKU7657/06M, 761407M.

References

 

DC FieldValueLanguage
dc.contributor.authorLai, CHen_HK
dc.contributor.authorYiu, CNSen_HK
dc.contributor.authorLai, SKen_HK
dc.contributor.authorNg, KPen_HK
dc.contributor.authorYung, KKLen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-10-31T11:23:07Z-
dc.date.available2010-10-31T11:23:07Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Comparative Neurology, 2010, v. 518 n. 10, p. 1742-1763en_HK
dc.identifier.issn0021-9967en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125298-
dc.description.abstractWe examined the functional maturation of canal-related brainstem neurons in Sprague-Dawley rats at postnatal day (P) 1 to adult. Conscious animals were subjected to cycles of angular acceleration and deceleration so as to selectively activate hair cells of the horizontal semicircular canals. Brainstem neurons were monitored for c-fos expression by immune-hybridization histochemistry as an indicator of neuronal activation. Fos-immunoreactive canalrelated neurons were identifiable from P4 onwards in the vestibular nucleus and downstream vestibular relay stations, propositus hypoglossal nucleus, and inferior olive. In the vestibular nucleus and prepositus hypoglossal nucleus, the number of canal-related neurons increased progressively with age, reaching the adult level by P21. Those in the inferior olive increased in number from P4to P14 but decreased significantly afterwards until adulthood. The topography was not clear in the vestibular nucleus and pre-positus hypoglossal nucleus. Canal-related neurons in P4 -7 rats were spread throughout the rostrocaudal length of each subnucleus but clusters of canal-related neurons tended to form within specific subnuclei by P21. These were concentrated in the caudal halves of medial and spinal vestibular nuclei and the rostral parts of superior vestibular nucleus and prepositus hypoglossal nucleus. In the inferior olive, the topography was evident early in the course of development. Canal-related neurons were exclusively located in four subnuclei: dorsal medial cell column, dorsal cap, subnucleus A, and subnucleus C, but not in other subnuclei. Taken together, our data revealed the developmental profile of neuronal subpopulations within the horizontal canal system, thus providing an internal neural representation for postnatal coding of horizontal head rotations in spatial perception. © 2009 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248en_HK
dc.relation.ispartofJournal of Comparative Neurologyen_HK
dc.rightsThe Journal of Comparative Neurology. Copyright © John Wiley & Sons, Inc.-
dc.subjectC-fosen_HK
dc.subjectCanalen_HK
dc.subjectDevelopmenten_HK
dc.subjectInferior oliveen_HK
dc.subjectVestibular nucleien_HK
dc.subject.meshAcceleration-
dc.subject.meshAnimals-
dc.subject.meshBrain Stem - cytology-
dc.subject.meshMotion Perception - physiology-
dc.subject.meshNeurons - cytology - physiology-
dc.titleMaturation of canal-related brainstem neurons in the detection of horizontal angular acceleration in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9967&volume=518&issue=10&spage=1742&epage=1763&date=2010&atitle=Maturation+of+canal-related+brainstem+neurons+in+the+detection+of+horizontal+angular+acceleration+in+rats-
dc.identifier.emailLai, CH: chlaib@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cne.22300en_HK
dc.identifier.pmid20235168-
dc.identifier.scopuseid_2-s2.0-77952138611en_HK
dc.identifier.hkuros173269en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952138611&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume518en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1742en_HK
dc.identifier.epage1763en_HK
dc.identifier.eissn1096-9861-
dc.identifier.isiWOS:000276499800008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLai, CH=7403086597en_HK
dc.identifier.scopusauthoridYiu, CNS=36143442800en_HK
dc.identifier.scopusauthoridLai, SK=7402937165en_HK
dc.identifier.scopusauthoridNg, KP=36143222600en_HK
dc.identifier.scopusauthoridYung, KKL=13605496000en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK

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