File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Secretin as a neurohypophysial factor regulating body water homeostasis

TitleSecretin as a neurohypophysial factor regulating body water homeostasis
Authors
KeywordsHypothalamic-pituitary axis
Osmoregulation
Vasopressin
Issue Date2009
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2009, v. 106 n. 37, p. 15961-15966 How to Cite?
AbstractHypothalamic magnocellular neurons express either one of the neurohypophysial hormones, vasopressin or oxytocin, along with different neuropeptides or neuromodulators. Axonal terminals of these neurons are generally accepted to release solely the two hormones but not others into the circulation. Here, we show that secretin, originally isolated from upper intestinal mucosal extract, is present throughout the hypothalamo- neurohypophysial axis and that it is released from the posterior pituitary under plasma hyperosmolality conditions. In the hypothalamus, it stimulates vasopressin expression and release. Considering these findings together with our previous findings that show a direct effect of secretin on renal water reabsorption, wepropose here that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis. Findings presented here challenge previous understanding regarding the neurohypophysis and could provide new concepts in treating disorders related to osmoregulation.
Persistent Identifierhttp://hdl.handle.net/10722/125296
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong government Research Grants CouncilHKU7501/05M
HKU7384/04M
GRF763809
GRF768608
F-HK31/07T
Funding Information:

We are grateful to Simon S. M. Chan for his excellent technical assistance in the in vivo stimulation experiments. This work was supported by Hong Kong government Research Grants Council Grants HKU7501/05M, HKU7384/04M, and GRF763809 (to B. K. C. C.), GRF768608 (to L.T.O.L.), and F-HK31/07T (to H. V. and B. K. C. C.).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChu, JYSen_HK
dc.contributor.authorLee, LTOen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorVaudry, Hen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-10-31T11:23:01Z-
dc.date.available2010-10-31T11:23:01Z-
dc.date.issued2009en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2009, v. 106 n. 37, p. 15961-15966en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125296-
dc.description.abstractHypothalamic magnocellular neurons express either one of the neurohypophysial hormones, vasopressin or oxytocin, along with different neuropeptides or neuromodulators. Axonal terminals of these neurons are generally accepted to release solely the two hormones but not others into the circulation. Here, we show that secretin, originally isolated from upper intestinal mucosal extract, is present throughout the hypothalamo- neurohypophysial axis and that it is released from the posterior pituitary under plasma hyperosmolality conditions. In the hypothalamus, it stimulates vasopressin expression and release. Considering these findings together with our previous findings that show a direct effect of secretin on renal water reabsorption, wepropose here that secretin works at multiple levels in the hypothalamus, pituitary, and kidney to regulate water homeostasis. Findings presented here challenge previous understanding regarding the neurohypophysis and could provide new concepts in treating disorders related to osmoregulation.en_HK
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.rightsProceedings of the National Academy of Sciences. Copyright © National Academy of Sciences.-
dc.subjectHypothalamic-pituitary axisen_HK
dc.subjectOsmoregulationen_HK
dc.subjectVasopressinen_HK
dc.subject.meshAnimals-
dc.subject.meshBase Sequence-
dc.subject.meshBody Water - physiology-
dc.subject.meshPituitary Gland, Posterior - physiology-
dc.subject.meshSecretin - blood - genetics - physiology-
dc.titleSecretin as a neurohypophysial factor regulating body water homeostasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-8424&volume=106&issue=37&spage=15961&epage=15966&date=2009&atitle=Secretin+as+a+neurohypophysial+factor+regulating+body+water+homeostasis-
dc.identifier.emailChu, JYS: hitan@graduate.hku.hken_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@hku.hken_HK
dc.identifier.emailChan, YS: yschan@hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityChu, JYS=rp00684en_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1073/pnas.0903695106en_HK
dc.identifier.pmid19805236-
dc.identifier.pmcidPMC2747226-
dc.identifier.scopuseid_2-s2.0-70349465003en_HK
dc.identifier.hkuros173268en_HK
dc.identifier.hkuros174267-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349465003&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume106en_HK
dc.identifier.issue37en_HK
dc.identifier.spage15961en_HK
dc.identifier.epage15966en_HK
dc.identifier.eissn1091-6490-
dc.identifier.isiWOS:000269806600081-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001165372-
dc.relation.projectDiscovery of novel growth hormone-releasing hormones in vertebrates: from functions to evolution-
dc.identifier.scopusauthoridChu, JYS=34975209300en_HK
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK
dc.identifier.scopusauthoridLai, CH=7403086597en_HK
dc.identifier.scopusauthoridVaudry, H=35446602600en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridYung, WH=7103137893en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats