File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Time course of cortically induced fos expression in auditory thalamus and midbrain after bilateral cochlear ablation

TitleTime course of cortically induced fos expression in auditory thalamus and midbrain after bilateral cochlear ablation
Authors
Keywordsbicuculline
cochleostomy
corticofugal activation
denervation hypersensitivity
inferior colliculus
medial geniculate body
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 2009, v. 160 n. 1, p. 186-197 How to Cite?
AbstractExpression of c-fos in the medial geniculate body (MGB) and the inferior colliculus (IC) in response to bicuculline-induced corticofugal activation was examined in rats at different time points after bilateral cochlear ablation (4 h-30 days). Corticofugal activation was crucial in eliciting Fos expression in the MGB after cochlear ablation. The pars ovoidea (OV) of the medial geniculate body ventral division (MGv) showed dense Fos expression 4 h after cochlear ablation; the expression declined to very low levels at 24 h and thereafter. In turn, strong Fos expression was found in the pars lateralis (LV) of the MGv 24 h after cochlear ablation and dropped dramatically at 14 days. The dorsal division of the MGB (MGd) showed high Fos expression 7 days after cochlear ablation, which persisted for a period of time. Using multi-electrode recordings, neuronal activity of different MGB subnuclei was found to correlate well with Fos expressions. The temporal changes in cortically activated Fos expression in different MGB subnuclei after bilateral cochlear ablation indicate differential denervation hypersensitivities of these MGB neurons and likely point to differential dependence of these nuclei on both auditory ascending and corticofugal descending inputs. After bilateral cochlear ablation, significant increases in Fos-positive neurons were detected unilaterally in all IC subnuclei, ipsilateral to the bicuculline injection. © 2009 IBRO.
Persistent Identifierhttp://hdl.handle.net/10722/125295
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong ResearchCERG PolyU 5467105 M
Funding Information:

We thank Simon S. M. Chan and Kimmy F. L. Tsang of the University of Hong Kong for their excellent technical assistance in the experiments. This work was supported by the Hong Kong Research Grants Council (CERG PolyU 5467105 M).

References

 

DC FieldValueLanguage
dc.contributor.authorSun, Xen_HK
dc.contributor.authorGuo, YPen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2010-10-31T11:22:57Z-
dc.date.available2010-10-31T11:22:57Z-
dc.date.issued2009en_HK
dc.identifier.citationNeuroscience, 2009, v. 160 n. 1, p. 186-197en_HK
dc.identifier.issn0306-4522en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125295-
dc.description.abstractExpression of c-fos in the medial geniculate body (MGB) and the inferior colliculus (IC) in response to bicuculline-induced corticofugal activation was examined in rats at different time points after bilateral cochlear ablation (4 h-30 days). Corticofugal activation was crucial in eliciting Fos expression in the MGB after cochlear ablation. The pars ovoidea (OV) of the medial geniculate body ventral division (MGv) showed dense Fos expression 4 h after cochlear ablation; the expression declined to very low levels at 24 h and thereafter. In turn, strong Fos expression was found in the pars lateralis (LV) of the MGv 24 h after cochlear ablation and dropped dramatically at 14 days. The dorsal division of the MGB (MGd) showed high Fos expression 7 days after cochlear ablation, which persisted for a period of time. Using multi-electrode recordings, neuronal activity of different MGB subnuclei was found to correlate well with Fos expressions. The temporal changes in cortically activated Fos expression in different MGB subnuclei after bilateral cochlear ablation indicate differential denervation hypersensitivities of these MGB neurons and likely point to differential dependence of these nuclei on both auditory ascending and corticofugal descending inputs. After bilateral cochlear ablation, significant increases in Fos-positive neurons were detected unilaterally in all IC subnuclei, ipsilateral to the bicuculline injection. © 2009 IBRO.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_HK
dc.relation.ispartofNeuroscienceen_HK
dc.subjectbicucullineen_HK
dc.subjectcochleostomyen_HK
dc.subjectcorticofugal activationen_HK
dc.subjectdenervation hypersensitivityen_HK
dc.subjectinferior colliculusen_HK
dc.subjectmedial geniculate bodyen_HK
dc.subject.meshCochlea - injuries-
dc.subject.meshGeniculate Bodies - drug effects - metabolism-
dc.subject.meshInferior Colliculi - drug effects - metabolism-
dc.subject.meshNeurons - drug effects - metabolism-
dc.subject.meshProto-Oncogene Proteins c-fos - metabolism-
dc.titleTime course of cortically induced fos expression in auditory thalamus and midbrain after bilateral cochlear ablationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0306-4522&volume=160&issue=1&spage=186&epage=197&date=2009&atitle=Time+course+of+cortically+induced+fos+expression+in+auditory+thalamus+and+midbrain+after+bilateral+cochlear+ablation-
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuroscience.2009.02.020en_HK
dc.identifier.pmid19232381-
dc.identifier.scopuseid_2-s2.0-63949083528en_HK
dc.identifier.hkuros174413en_HK
dc.identifier.hkuros164164-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63949083528&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume160en_HK
dc.identifier.issue1en_HK
dc.identifier.spage186en_HK
dc.identifier.epage197en_HK
dc.identifier.isiWOS:000265344800019-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridSun, X=7405621422en_HK
dc.identifier.scopusauthoridGuo, YP=37070158700en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridHe, J=7404984971en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats