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- Publisher Website: 10.1016/j.neuroscience.2009.02.020
- Scopus: eid_2-s2.0-63949083528
- PMID: 19232381
- WOS: WOS:000265344800019
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Article: Time course of cortically induced fos expression in auditory thalamus and midbrain after bilateral cochlear ablation
Title | Time course of cortically induced fos expression in auditory thalamus and midbrain after bilateral cochlear ablation | ||||
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Authors | |||||
Keywords | bicuculline cochleostomy corticofugal activation denervation hypersensitivity inferior colliculus medial geniculate body | ||||
Issue Date | 2009 | ||||
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience | ||||
Citation | Neuroscience, 2009, v. 160 n. 1, p. 186-197 How to Cite? | ||||
Abstract | Expression of c-fos in the medial geniculate body (MGB) and the inferior colliculus (IC) in response to bicuculline-induced corticofugal activation was examined in rats at different time points after bilateral cochlear ablation (4 h-30 days). Corticofugal activation was crucial in eliciting Fos expression in the MGB after cochlear ablation. The pars ovoidea (OV) of the medial geniculate body ventral division (MGv) showed dense Fos expression 4 h after cochlear ablation; the expression declined to very low levels at 24 h and thereafter. In turn, strong Fos expression was found in the pars lateralis (LV) of the MGv 24 h after cochlear ablation and dropped dramatically at 14 days. The dorsal division of the MGB (MGd) showed high Fos expression 7 days after cochlear ablation, which persisted for a period of time. Using multi-electrode recordings, neuronal activity of different MGB subnuclei was found to correlate well with Fos expressions. The temporal changes in cortically activated Fos expression in different MGB subnuclei after bilateral cochlear ablation indicate differential denervation hypersensitivities of these MGB neurons and likely point to differential dependence of these nuclei on both auditory ascending and corticofugal descending inputs. After bilateral cochlear ablation, significant increases in Fos-positive neurons were detected unilaterally in all IC subnuclei, ipsilateral to the bicuculline injection. © 2009 IBRO. | ||||
Persistent Identifier | http://hdl.handle.net/10722/125295 | ||||
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.903 | ||||
ISI Accession Number ID |
Funding Information: We thank Simon S. M. Chan and Kimmy F. L. Tsang of the University of Hong Kong for their excellent technical assistance in the experiments. This work was supported by the Hong Kong Research Grants Council (CERG PolyU 5467105 M). | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sun, X | en_HK |
dc.contributor.author | Guo, YP | en_HK |
dc.contributor.author | Shum, DKY | en_HK |
dc.contributor.author | Chan, YS | en_HK |
dc.contributor.author | He, J | en_HK |
dc.date.accessioned | 2010-10-31T11:22:57Z | - |
dc.date.available | 2010-10-31T11:22:57Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Neuroscience, 2009, v. 160 n. 1, p. 186-197 | en_HK |
dc.identifier.issn | 0306-4522 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/125295 | - |
dc.description.abstract | Expression of c-fos in the medial geniculate body (MGB) and the inferior colliculus (IC) in response to bicuculline-induced corticofugal activation was examined in rats at different time points after bilateral cochlear ablation (4 h-30 days). Corticofugal activation was crucial in eliciting Fos expression in the MGB after cochlear ablation. The pars ovoidea (OV) of the medial geniculate body ventral division (MGv) showed dense Fos expression 4 h after cochlear ablation; the expression declined to very low levels at 24 h and thereafter. In turn, strong Fos expression was found in the pars lateralis (LV) of the MGv 24 h after cochlear ablation and dropped dramatically at 14 days. The dorsal division of the MGB (MGd) showed high Fos expression 7 days after cochlear ablation, which persisted for a period of time. Using multi-electrode recordings, neuronal activity of different MGB subnuclei was found to correlate well with Fos expressions. The temporal changes in cortically activated Fos expression in different MGB subnuclei after bilateral cochlear ablation indicate differential denervation hypersensitivities of these MGB neurons and likely point to differential dependence of these nuclei on both auditory ascending and corticofugal descending inputs. After bilateral cochlear ablation, significant increases in Fos-positive neurons were detected unilaterally in all IC subnuclei, ipsilateral to the bicuculline injection. © 2009 IBRO. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience | en_HK |
dc.relation.ispartof | Neuroscience | en_HK |
dc.subject | bicuculline | en_HK |
dc.subject | cochleostomy | en_HK |
dc.subject | corticofugal activation | en_HK |
dc.subject | denervation hypersensitivity | en_HK |
dc.subject | inferior colliculus | en_HK |
dc.subject | medial geniculate body | en_HK |
dc.subject.mesh | Cochlea - injuries | - |
dc.subject.mesh | Geniculate Bodies - drug effects - metabolism | - |
dc.subject.mesh | Inferior Colliculi - drug effects - metabolism | - |
dc.subject.mesh | Neurons - drug effects - metabolism | - |
dc.subject.mesh | Proto-Oncogene Proteins c-fos - metabolism | - |
dc.title | Time course of cortically induced fos expression in auditory thalamus and midbrain after bilateral cochlear ablation | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0306-4522&volume=160&issue=1&spage=186&epage=197&date=2009&atitle=Time+course+of+cortically+induced+fos+expression+in+auditory+thalamus+and+midbrain+after+bilateral+cochlear+ablation | - |
dc.identifier.email | Shum, DKY: shumdkhk@hkucc.hku.hk | en_HK |
dc.identifier.email | Chan, YS: yschan@hkucc.hku.hk | en_HK |
dc.identifier.authority | Shum, DKY=rp00321 | en_HK |
dc.identifier.authority | Chan, YS=rp00318 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.neuroscience.2009.02.020 | en_HK |
dc.identifier.pmid | 19232381 | - |
dc.identifier.scopus | eid_2-s2.0-63949083528 | en_HK |
dc.identifier.hkuros | 174413 | en_HK |
dc.identifier.hkuros | 164164 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-63949083528&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 160 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 186 | en_HK |
dc.identifier.epage | 197 | en_HK |
dc.identifier.isi | WOS:000265344800019 | - |
dc.publisher.place | Netherlands | en_HK |
dc.identifier.scopusauthorid | Sun, X=7405621422 | en_HK |
dc.identifier.scopusauthorid | Guo, YP=37070158700 | en_HK |
dc.identifier.scopusauthorid | Shum, DKY=7004824447 | en_HK |
dc.identifier.scopusauthorid | Chan, YS=7403676627 | en_HK |
dc.identifier.scopusauthorid | He, J=7404984971 | en_HK |
dc.identifier.issnl | 0306-4522 | - |