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Article: International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers
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TitleInternational reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers
 
AuthorsKirk, P2
He, T2
Anderson, LJ2
Roughton, M2
Tanner, MA2
Lam, WWM10
Au, WY5
Chu, WCW10
Chan, G5
Galanello, R8
Matta, G7
Fogel, M4
Cohen, AR4
Tan, RS6
Chen, K1
Ng, I3
Lai, A3
Fucharoen, S9
Laothamata, J9
Chuncharunee, S9
Jongjirasiri, S9
Firmin, DN2
Smith, GC2
Pennell, DJ2
 
KeywordsCardiac siderosis
Cardiomyopathy
Cardiovascular MR
Thalassemia
 
Issue Date2010
 
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
 
CitationJournal Of Magnetic Resonance Imaging, 2010, v. 32 n. 2, p. 315-319 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jmri.22245
 
AbstractPurpose: To examine the reproducibility of the single breathhold T2* technique fromdifferent scanners, after installation of standardmethodology in five international centers. Materials and Methods: Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed. Results: Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver. Conclusion: These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well-defined and approved imaging and analysis techniques are used. © 2010 Wiley-Liss, Inc.
 
ISSN1053-1807
2012 Impact Factor: 2.566
2012 SCImago Journal Rankings: 1.330
 
DOIhttp://dx.doi.org/10.1002/jmri.22245
 
PubMed Central IDPMC2946327
 
ISI Accession Number IDWOS:000280447300008
Funding AgencyGrant Number
National Institutes of Health5 R01 DK066084-02
National Institutes of Health Research Biomedical Research Unit of Royal Brompton Hospital
Imperial College
Funding Information:

Contract grant sponsor: National Institutes of Health; Contract grant number: 5 R01 DK066084-02

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKirk, P
 
dc.contributor.authorHe, T
 
dc.contributor.authorAnderson, LJ
 
dc.contributor.authorRoughton, M
 
dc.contributor.authorTanner, MA
 
dc.contributor.authorLam, WWM
 
dc.contributor.authorAu, WY
 
dc.contributor.authorChu, WCW
 
dc.contributor.authorChan, G
 
dc.contributor.authorGalanello, R
 
dc.contributor.authorMatta, G
 
dc.contributor.authorFogel, M
 
dc.contributor.authorCohen, AR
 
dc.contributor.authorTan, RS
 
dc.contributor.authorChen, K
 
dc.contributor.authorNg, I
 
dc.contributor.authorLai, A
 
dc.contributor.authorFucharoen, S
 
dc.contributor.authorLaothamata, J
 
dc.contributor.authorChuncharunee, S
 
dc.contributor.authorJongjirasiri, S
 
dc.contributor.authorFirmin, DN
 
dc.contributor.authorSmith, GC
 
dc.contributor.authorPennell, DJ
 
dc.date.accessioned2010-10-31T11:18:54Z
 
dc.date.available2010-10-31T11:18:54Z
 
dc.date.issued2010
 
dc.description.abstractPurpose: To examine the reproducibility of the single breathhold T2* technique fromdifferent scanners, after installation of standardmethodology in five international centers. Materials and Methods: Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed. Results: Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver. Conclusion: These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well-defined and approved imaging and analysis techniques are used. © 2010 Wiley-Liss, Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2010, v. 32 n. 2, p. 315-319 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jmri.22245
 
dc.identifier.doihttp://dx.doi.org/10.1002/jmri.22245
 
dc.identifier.epage319
 
dc.identifier.hkuros179097
 
dc.identifier.isiWOS:000280447300008
Funding AgencyGrant Number
National Institutes of Health5 R01 DK066084-02
National Institutes of Health Research Biomedical Research Unit of Royal Brompton Hospital
Imperial College
Funding Information:

Contract grant sponsor: National Institutes of Health; Contract grant number: 5 R01 DK066084-02

 
dc.identifier.issn1053-1807
2012 Impact Factor: 2.566
2012 SCImago Journal Rankings: 1.330
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC2946327
 
dc.identifier.pmid20677256
 
dc.identifier.scopuseid_2-s2.0-77955365667
 
dc.identifier.spage315
 
dc.identifier.urihttp://hdl.handle.net/10722/125231
 
dc.identifier.volume32
 
dc.languageeng
 
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Magnetic Resonance Imaging
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Magnetic Resonance Imaging. Copyright © John Wiley & Sons, Inc.
 
dc.subjectCardiac siderosis
 
dc.subjectCardiomyopathy
 
dc.subjectCardiovascular MR
 
dc.subjectThalassemia
 
dc.titleInternational reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers
 
dc.typeArticle
 
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Author Affiliations
  1. Singapore General Hospital
  2. Royal Brompton Hospital
  3. KK Women's And Children's Hospital
  4. The Children's Hospital of Philadelphia
  5. The University of Hong Kong
  6. National Heart Centre, Singapore
  7. Azienda Ospedaliera Brotzu
  8. Ospedale Regionale Microcitemie
  9. Mahidol University
  10. Chinese University of Hong Kong