Article: International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers

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TitleInternational reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers
AuthorsKirk, P8
He, T8
Anderson, LJ8
Roughton, M8
Tanner, MA8
Lam, WWM10
Au, WY4
Chu, WCW10
Chan, G4
Galanello, R7
Matta, G6
Fogel, M3
Cohen, AR3
Tan, RS5
Chen, K1
Ng, I2
Lai, A2
Fucharoen, S9
Laothamata, J9
Chuncharunee, S9
Jongjirasiri, S9
Firmin, DN8
Smith, GC8
Pennell, DJ8
KeywordsCardiac siderosis
Cardiomyopathy
Cardiovascular MR
Thalassemia
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
CitationJournal Of Magnetic Resonance Imaging, 2010, v. 32 n. 2, p. 315-319 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jmri.22245
AbstractPurpose: To examine the reproducibility of the single breathhold T2* technique fromdifferent scanners, after installation of standardmethodology in five international centers. Materials and Methods: Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed. Results: Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver. Conclusion: These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well-defined and approved imaging and analysis techniques are used. © 2010 Wiley-Liss, Inc.
ISSN1053-1807
2011 Impact Factor: 2.698
2011 SCImago Journal Rankings: 0.242
DOIhttp://dx.doi.org/10.1002/jmri.22245
ISI Accession Number IDWOS:000280447300008
Funding AgencyGrant Number
National Institutes of Health5 R01 DK066084-02
National Institutes of Health Research Biomedical Research Unit of Royal Brompton Hospital
Imperial College
Funding Information:

Contract grant sponsor: National Institutes of Health; Contract grant number: 5 R01 DK066084-02

PubMed Central IDPMC2946327
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorKirk, P
dc.contributor.authorHe, T
dc.contributor.authorAnderson, LJ
dc.contributor.authorRoughton, M
dc.contributor.authorTanner, MA
dc.contributor.authorLam, WWM
dc.contributor.authorAu, WY
dc.contributor.authorChu, WCW
dc.contributor.authorChan, G
dc.contributor.authorGalanello, R
dc.contributor.authorMatta, G
dc.contributor.authorFogel, M
dc.contributor.authorCohen, AR
dc.contributor.authorTan, RS
dc.contributor.authorChen, K
dc.contributor.authorNg, I
dc.contributor.authorLai, A
dc.contributor.authorFucharoen, S
dc.contributor.authorLaothamata, J
dc.contributor.authorChuncharunee, S
dc.contributor.authorJongjirasiri, S
dc.contributor.authorFirmin, DN
dc.contributor.authorSmith, GC
dc.contributor.authorPennell, DJ
dc.date.accessioned2010-10-31T11:18:54Z
dc.date.available2010-10-31T11:18:54Z
dc.date.issued2010
dc.description.abstractPurpose: To examine the reproducibility of the single breathhold T2* technique fromdifferent scanners, after installation of standardmethodology in five international centers. Materials and Methods: Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed. Results: Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver. Conclusion: These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well-defined and approved imaging and analysis techniques are used. © 2010 Wiley-Liss, Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2010, v. 32 n. 2, p. 315-319 [How to Cite?]
DOI: http://dx.doi.org/10.1002/jmri.22245
dc.identifier.doihttp://dx.doi.org/10.1002/jmri.22245
dc.identifier.epage319
dc.identifier.hkuros179097
dc.identifier.isiWOS:000280447300008
Funding AgencyGrant Number
National Institutes of Health5 R01 DK066084-02
National Institutes of Health Research Biomedical Research Unit of Royal Brompton Hospital
Imperial College
Funding Information:

Contract grant sponsor: National Institutes of Health; Contract grant number: 5 R01 DK066084-02

dc.identifier.issn1053-1807
2011 Impact Factor: 2.698
2011 SCImago Journal Rankings: 0.242
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmcidPMC2946327
dc.identifier.pmid20677256
dc.identifier.scopuseid_2-s2.0-77955365667
dc.identifier.spage315
dc.identifier.urihttp://hdl.handle.net/10722/125231
dc.identifier.volume32
dc.languageeng
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Magnetic Resonance Imaging
dc.relation.referencesReferences in Scopus
dc.rightsJournal of Magnetic Resonance Imaging. Copyright © John Wiley & Sons, Inc.
dc.subjectCardiac siderosis
dc.subjectCardiomyopathy
dc.subjectCardiovascular MR
dc.subjectThalassemia
dc.titleInternational reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers
dc.typeArticle
Author Affiliations
  1. Singapore General Hospital
  2. KK Women's And Children's Hospital
  3. The Children's Hospital of Philadelphia
  4. The University of Hong Kong
  5. National Heart Centre, Singapore
  6. Azienda Ospedaliera Brotzu
  7. null
  8. Imperial College London
  9. Mahidol University
  10. Chinese University of Hong Kong