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Article: Autism spectrum disorders and epigenetics

TitleAutism spectrum disorders and epigenetics
Authors
Keywordsautism spectrum disorders
epigenetics
genetics
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.jaacap.com/
Citation
Journal Of The American Academy Of Child And Adolescent Psychiatry, 2010, v. 49 n. 8, p. 794-809 How to Cite?
AbstractObjective: Current research suggests that the causes of autism spectrum disorders (ASD) are multifactorial and include both genetic and environmental factors. Several lines of evidence suggest that epigenetics also plays an important role in ASD etiology and that it might, in fact, integrate genetic and environmental influences to dysregulate neurodevelopmental processes. The objective of this review is to illustrate how epigenetic modifications that are known to alter gene expression without changing primary DNA sequence may play a role in the etiology of ASD. Method: In this review, we summarize current knowledge about epigenetic modifications to genes and genomic regions possibly involved in the etiology of ASD. Results: Several genetic syndromes comorbid with ASD, which include Rett, Fragile X, Prader-Willi, Angelman, and CHARGE (Coloboma of the eye, Heart defects, Atresia of the nasal choanae, Retardation of growth and/or development, Genital and/or urinary abnormalities, and Ear abnormalities and deafness), all demonstrate dysregulation of epigenetic marks or epigenetic mechanisms. We report also on genes or genomic regions exhibiting abnormal epigenetic regulation in association with either syndromic (15q11-13 maternal duplication) or nonsyndromic forms of ASD. Finally, we discuss the state of current knowledge regarding the etiologic role of environmental factors linked to both the development of ASD and epigenetic dysregulation. Conclusion: Data reviewed in this article highlight a variety of situations in which epigenetic dysregulation is associated with the development of ASD, thereby supporting a role for epigenetics in the multifactorial etiologies of ASD. © 2010 American Academy of Child and Adolescent Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/125223
ISSN
2015 Impact Factor: 7.182
2015 SCImago Journal Rankings: 3.390
ISI Accession Number ID
Funding AgencyGrant Number
Canadian Institute of Heath Research
Funding Information:

Funding for this work was provided by the Canadian Institute of Heath Research

References

 

DC FieldValueLanguage
dc.contributor.authorGrafodatskaya, Den_HK
dc.contributor.authorChung, Ben_HK
dc.contributor.authorSzatmari, Pen_HK
dc.contributor.authorWeksberg, Ren_HK
dc.date.accessioned2010-10-31T11:18:28Z-
dc.date.available2010-10-31T11:18:28Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of The American Academy Of Child And Adolescent Psychiatry, 2010, v. 49 n. 8, p. 794-809en_HK
dc.identifier.issn0890-8567en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125223-
dc.description.abstractObjective: Current research suggests that the causes of autism spectrum disorders (ASD) are multifactorial and include both genetic and environmental factors. Several lines of evidence suggest that epigenetics also plays an important role in ASD etiology and that it might, in fact, integrate genetic and environmental influences to dysregulate neurodevelopmental processes. The objective of this review is to illustrate how epigenetic modifications that are known to alter gene expression without changing primary DNA sequence may play a role in the etiology of ASD. Method: In this review, we summarize current knowledge about epigenetic modifications to genes and genomic regions possibly involved in the etiology of ASD. Results: Several genetic syndromes comorbid with ASD, which include Rett, Fragile X, Prader-Willi, Angelman, and CHARGE (Coloboma of the eye, Heart defects, Atresia of the nasal choanae, Retardation of growth and/or development, Genital and/or urinary abnormalities, and Ear abnormalities and deafness), all demonstrate dysregulation of epigenetic marks or epigenetic mechanisms. We report also on genes or genomic regions exhibiting abnormal epigenetic regulation in association with either syndromic (15q11-13 maternal duplication) or nonsyndromic forms of ASD. Finally, we discuss the state of current knowledge regarding the etiologic role of environmental factors linked to both the development of ASD and epigenetic dysregulation. Conclusion: Data reviewed in this article highlight a variety of situations in which epigenetic dysregulation is associated with the development of ASD, thereby supporting a role for epigenetics in the multifactorial etiologies of ASD. © 2010 American Academy of Child and Adolescent Psychiatry.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.jaacap.com/en_HK
dc.relation.ispartofJournal of the American Academy of Child and Adolescent Psychiatryen_HK
dc.subjectautism spectrum disordersen_HK
dc.subjectepigeneticsen_HK
dc.subjectgeneticsen_HK
dc.titleAutism spectrum disorders and epigeneticsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0890-8567&volume=49&issue=8&spage=794&epage=809&date=2010&atitle=Autism+spectrum+disorders+and+epigenetics+(with+Editorial+Comments)-
dc.identifier.emailChung, B:bhychung@hku.hken_HK
dc.identifier.authorityChung, B=rp00473en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jaac.2010.05.005en_HK
dc.identifier.pmid20643313-
dc.identifier.scopuseid_2-s2.0-77955701221en_HK
dc.identifier.hkuros174633en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955701221&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue8en_HK
dc.identifier.spage794en_HK
dc.identifier.epage809en_HK
dc.identifier.eissn1527-5418-
dc.identifier.isiWOS:000280436700006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGrafodatskaya, D=36096694800en_HK
dc.identifier.scopusauthoridChung, B=7203043997en_HK
dc.identifier.scopusauthoridSzatmari, P=7006673362en_HK
dc.identifier.scopusauthoridWeksberg, R=7006112330en_HK
dc.identifier.citeulike8985804-

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