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Article: Virologically confirmed population-based burden of hospitalization caused by respiratory syncytial virus, adenovirus, and parainfluenza viruses in children in Hong Kong

TitleVirologically confirmed population-based burden of hospitalization caused by respiratory syncytial virus, adenovirus, and parainfluenza viruses in children in Hong Kong
Authors
Keywordschildren
hospitalization disease burden
population-based
respiratory virus
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.com
Citation
Pediatric Infectious Disease Journal, 2010, v. 29 n. 12, p. 1088-1092 How to Cite?
AbstractObjectives: To determine virologically confirmed hospitalization rates associated with respiratory syncytial virus (RSV), adenovirus, and parainfluenza viruses in Hong Kong children. Methods: All patients <18 years of age living on Hong Kong Island (within Hong Kong SAR) admitted for a febrile acute respiratory infection to 1 of the 2 public hospitals on 1 fixed day of the week between October 2003 and September 2006 were prospectively recruited. Hong Kong Island has a known population denominator and these 2 hospitals managed 72.5% of all general pediatric admissions for this population. Nasopharyngeal aspirates were tested for RSV, adenovirus, and parainfluenzae types 1, 2, and 3 by direct antigen detection and culture. Results: The annual hospitalization rate for RSV in infants <6 months of age was 233.4 to 311.2 per 10,000. Parainfluenza type 3 had a hospitalization rate of 27.3 to 122.8 per 10,000 in the 1 to <2 years group. Adenovirus was associated with significant hospitalization in those 6 months to 1 year (25.9-77.8 per 10,000), and in those 2 to <5 years (38.1-59.2 per 10,000). The mean duration of hospitalization for RSV was 4.04 ± 2.61 days, significantly longer than the 3.12 ± 1.41 days for adenovirus and the 2.93 ± 2.54 days for parainfluenza infections (P = 0.013 and P = 0.038, respectively). CONCLUSION:: We documented that the overall pediatric hospitalization burden of RSV was high and comparable to that of influenza. The burden for all the studied viruses was mainly in previously healthy children <5 years of age. © 2010 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/125218
ISSN
2015 Impact Factor: 2.587
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong KongHKU 7396/03M
University Grants Committee of the Hong Kong Special Administrative Region GovernmentAoE/M-12/-06
Funding Information:

The authors thank Dr. Rowena Chua Shui Ching at PYNEH for helping with patient recruitment, and Ms. Eunice L.Y. Chan for coordinating the study. The authors acknowledge research grants from the Research Grants Council of Hong Kong (HKU 7396/03M) and the Area of Excellence Scheme of the University Grants Committee (grant AoE/M-12/-06) of the Hong Kong Special Administrative Region Government.

References
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DC FieldValueLanguage
dc.contributor.authorChiu, SSen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorYoung, BWen_HK
dc.contributor.authorLim, Wen_HK
dc.contributor.authorWong, WHSen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2010-10-31T11:18:11Z-
dc.date.available2010-10-31T11:18:11Z-
dc.date.issued2010en_HK
dc.identifier.citationPediatric Infectious Disease Journal, 2010, v. 29 n. 12, p. 1088-1092en_HK
dc.identifier.issn0891-3668en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125218-
dc.description.abstractObjectives: To determine virologically confirmed hospitalization rates associated with respiratory syncytial virus (RSV), adenovirus, and parainfluenza viruses in Hong Kong children. Methods: All patients <18 years of age living on Hong Kong Island (within Hong Kong SAR) admitted for a febrile acute respiratory infection to 1 of the 2 public hospitals on 1 fixed day of the week between October 2003 and September 2006 were prospectively recruited. Hong Kong Island has a known population denominator and these 2 hospitals managed 72.5% of all general pediatric admissions for this population. Nasopharyngeal aspirates were tested for RSV, adenovirus, and parainfluenzae types 1, 2, and 3 by direct antigen detection and culture. Results: The annual hospitalization rate for RSV in infants <6 months of age was 233.4 to 311.2 per 10,000. Parainfluenza type 3 had a hospitalization rate of 27.3 to 122.8 per 10,000 in the 1 to <2 years group. Adenovirus was associated with significant hospitalization in those 6 months to 1 year (25.9-77.8 per 10,000), and in those 2 to <5 years (38.1-59.2 per 10,000). The mean duration of hospitalization for RSV was 4.04 ± 2.61 days, significantly longer than the 3.12 ± 1.41 days for adenovirus and the 2.93 ± 2.54 days for parainfluenza infections (P = 0.013 and P = 0.038, respectively). CONCLUSION:: We documented that the overall pediatric hospitalization burden of RSV was high and comparable to that of influenza. The burden for all the studied viruses was mainly in previously healthy children <5 years of age. © 2010 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.pidj.comen_HK
dc.relation.ispartofPediatric Infectious Disease Journalen_HK
dc.subjectchildrenen_HK
dc.subjecthospitalization disease burdenen_HK
dc.subjectpopulation-baseden_HK
dc.subjectrespiratory virusen_HK
dc.subject.meshAdenoviridae Infections - epidemiology - pathology-
dc.subject.meshAdenoviruses, Human - isolation and purification-
dc.subject.meshHospitalization - statistics and numerical data-
dc.subject.meshParamyxoviridae Infections - epidemiology - pathology-
dc.subject.meshRespiratory Syncytial Virus Infections - epidemiology - pathology-
dc.titleVirologically confirmed population-based burden of hospitalization caused by respiratory syncytial virus, adenovirus, and parainfluenza viruses in children in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0891-3668&volume=29&issue=12&spage=1088&epage=1092&date=2010&atitle=Virologically+confirmed+population-based+burden+of+hospitalization+caused+by+respiratory+syncytial+virus,+adenovirus,+and+parainfluenza+viruses+in+children+in+Hong+Kong-
dc.identifier.emailChiu, SS: ssschiu@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/INF.0b013e3181e9de24en_HK
dc.identifier.pmid20622713-
dc.identifier.scopuseid_2-s2.0-78650416968en_HK
dc.identifier.hkuros180288en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650416968&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1088en_HK
dc.identifier.epage1092en_HK
dc.identifier.isiWOS:000284492500008-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectA population based study of hospitalization disease burden for respiratory viral infections in children-
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridChen, H=35181123000en_HK
dc.identifier.scopusauthoridYoung, BW=10143525400en_HK
dc.identifier.scopusauthoridLim, W=7202378277en_HK
dc.identifier.scopusauthoridWong, WHS=13310222200en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK

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