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Article: A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants

TitleA biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants
Authors
KeywordsBiocompatibility
Biodegradable
Corrosion
Magnesium
Polycaprolactone
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2010, v. 31 n. 8, p. 2084-2096 How to Cite?
AbstractMagnesium and its alloys may potentially be applied as degradable metallic materials in orthopaedic implantations due to their degradability and resemblance to human cortical bone. However, the high corrosion rate and accumulation of hydrogen gas upon degradation hinders its clinical application. In this study, we adopt a new approach to control the corrosion rate by coating a controllable polymeric membrane fabricated by polycaprolactone and dichloromethane onto magnesium alloys, in which the pore size was controlled during the manufacturing process. The addition of the polymeric membrane was found to reduce the degradation rate of magnesium, and the bulk mechanical properties were shown to be maintained upon degradation. The in-vitro studies indicated good cytocompatibility of eGFP and SaOS-2 osteoblasts with the polymer-coated samples, which was not observed for the uncoated samples. The in-vivo study indicated that the uncoated sample degraded more rapidly than that of the polymer-coated samples. Although new bone formation was found on both samples, as determined by Micro-CT, higher volumes of new bone were observed on the polymer-coated samples. Histological analysis indicated no inflammation, necrosis or hydrogen gas accumulation on either of the samples during degradation. Collectively, these data suggest that the use of polymeric membrane may be potentially applied for future clinical use. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/125210
ISSN
2015 Impact Factor: 8.387
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant Council718507
HKU University Research Council
Funding Information:

This study was financially supported by the Hong Kong Research Grant Council Competitive Earmarked Research Grant (#718507) and HKU University Research Council Seeding Fund.

References

 

DC FieldValueLanguage
dc.contributor.authorWong, HMen_HK
dc.contributor.authorYeung, KWKen_HK
dc.contributor.authorLam, KOen_HK
dc.contributor.authorTam, Ven_HK
dc.contributor.authorChu, PKen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorCheung, KMCen_HK
dc.date.accessioned2010-10-31T11:17:40Z-
dc.date.available2010-10-31T11:17:40Z-
dc.date.issued2010en_HK
dc.identifier.citationBiomaterials, 2010, v. 31 n. 8, p. 2084-2096en_HK
dc.identifier.issn0142-9612en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125210-
dc.description.abstractMagnesium and its alloys may potentially be applied as degradable metallic materials in orthopaedic implantations due to their degradability and resemblance to human cortical bone. However, the high corrosion rate and accumulation of hydrogen gas upon degradation hinders its clinical application. In this study, we adopt a new approach to control the corrosion rate by coating a controllable polymeric membrane fabricated by polycaprolactone and dichloromethane onto magnesium alloys, in which the pore size was controlled during the manufacturing process. The addition of the polymeric membrane was found to reduce the degradation rate of magnesium, and the bulk mechanical properties were shown to be maintained upon degradation. The in-vitro studies indicated good cytocompatibility of eGFP and SaOS-2 osteoblasts with the polymer-coated samples, which was not observed for the uncoated samples. The in-vivo study indicated that the uncoated sample degraded more rapidly than that of the polymer-coated samples. Although new bone formation was found on both samples, as determined by Micro-CT, higher volumes of new bone were observed on the polymer-coated samples. Histological analysis indicated no inflammation, necrosis or hydrogen gas accumulation on either of the samples during degradation. Collectively, these data suggest that the use of polymeric membrane may be potentially applied for future clinical use. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_HK
dc.relation.ispartofBiomaterialsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBiocompatibilityen_HK
dc.subjectBiodegradableen_HK
dc.subjectCorrosionen_HK
dc.subjectMagnesiumen_HK
dc.subjectPolycaprolactoneen_HK
dc.subject.meshAlloys - chemistry - metabolism-
dc.subject.meshCoated Materials, Biocompatible - chemistry - metabolism-
dc.subject.meshImplants, Experimental-
dc.subject.meshMagnesium - chemistry - metabolism-
dc.subject.meshPolymers - chemistry - metabolism-
dc.titleA biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implantsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0142-9612&volume=31&issue=8&spage=2084&epage=2096&date=2010&atitle=A+biodegradable+polymer-based+coating+to+control+the+performance+of+magnesium+alloy+orthopaedic+implants+en_HK
dc.identifier.emailYeung, KWK:wkkyeung@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.authorityYeung, KWK=rp00309en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.biomaterials.2009.11.111en_HK
dc.identifier.pmid20031201-
dc.identifier.scopuseid_2-s2.0-74449093616en_HK
dc.identifier.hkuros180207en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-74449093616&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue8en_HK
dc.identifier.spage2084en_HK
dc.identifier.epage2096en_HK
dc.identifier.eissn1878-5905-
dc.identifier.isiWOS:000275167300014-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWong, HM=35977282000en_HK
dc.identifier.scopusauthoridYeung, KWK=13309584700en_HK
dc.identifier.scopusauthoridLam, KO=22980533000en_HK
dc.identifier.scopusauthoridTam, V=35977084900en_HK
dc.identifier.scopusauthoridChu, PK=36040705700en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.citeulike6485120-

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