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Article: Bioactive borosilicate glass scaffolds: Improvement on the strength of glass-based scaffolds for tissue engineering

TitleBioactive borosilicate glass scaffolds: Improvement on the strength of glass-based scaffolds for tissue engineering
Authors
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530
Citation
Journal Of Materials Science: Materials In Medicine, 2009, v. 20 n. 1, p. 365-372 How to Cite?
AbstractThree-dimensional macroporous scaffolds with the pore size of 200-500 μm were fabricated by replication method using bioactive borosilicate glass from Na2O-K2O-MgO-CaO-SiO2-P2O 5-B2O3 system. The effects of the strength of the strut in reticulated scaffold, as well as the geometrical parameter of the scaffold on the strength of reticulated scaffold were investigated. Scanning electron microscope (SEM) and X-ray diffraction (XRD) results show that the solidified glass struts in the reticulated scaffold could be obtained through a sufficient vicious flow of glass, during the fabrication. By increasing the solid content in slurries, from which the scaffold was made, the load-bearing units of the reticulated scaffold switch from struts to the walls between the pores, and the compressive strength dramatically climbs higher than the theoretical strength calculated by Gibson model. In particular, the compressive strength of the reticulated scaffold, as high as ~10 MPa with the porosity of ~70%, is close to the reported compressive values of human cancellous bone. This indicates the bioactive borosilicate glass-based scaffold is a promising candidate for bone tissue engineering. © 2008 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/125200
ISSN
2015 Impact Factor: 2.272
2013 SCImago Journal Rankings: 0.897
ISI Accession Number ID
Funding AgencyGrant Number
Science and Technology Commission of Shanghai Municipality, China05DJ14006
Hong Kong RGC71437/07E
Funding Information:

This work was supported by the Science and Technology Commission of Shanghai Municipality, China, under Project (Grant No. 05DJ14006) and Hong Kong RGC: 71437/07E.

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorHuang, Wen_HK
dc.contributor.authorFu, Hen_HK
dc.contributor.authorYao, Aen_HK
dc.contributor.authorWang, Den_HK
dc.contributor.authorPan, Hen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2010-10-31T11:17:07Z-
dc.date.available2010-10-31T11:17:07Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Materials Science: Materials In Medicine, 2009, v. 20 n. 1, p. 365-372en_HK
dc.identifier.issn0957-4530en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125200-
dc.description.abstractThree-dimensional macroporous scaffolds with the pore size of 200-500 μm were fabricated by replication method using bioactive borosilicate glass from Na2O-K2O-MgO-CaO-SiO2-P2O 5-B2O3 system. The effects of the strength of the strut in reticulated scaffold, as well as the geometrical parameter of the scaffold on the strength of reticulated scaffold were investigated. Scanning electron microscope (SEM) and X-ray diffraction (XRD) results show that the solidified glass struts in the reticulated scaffold could be obtained through a sufficient vicious flow of glass, during the fabrication. By increasing the solid content in slurries, from which the scaffold was made, the load-bearing units of the reticulated scaffold switch from struts to the walls between the pores, and the compressive strength dramatically climbs higher than the theoretical strength calculated by Gibson model. In particular, the compressive strength of the reticulated scaffold, as high as ~10 MPa with the porosity of ~70%, is close to the reported compressive values of human cancellous bone. This indicates the bioactive borosilicate glass-based scaffold is a promising candidate for bone tissue engineering. © 2008 Springer Science+Business Media, LLC.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530en_HK
dc.relation.ispartofJournal of Materials Science: Materials in Medicineen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshBiomechanics-
dc.subject.meshBone Substitutes - chemistry-
dc.subject.meshCeramics - chemistry-
dc.subject.meshSilicates - chemistry-
dc.subject.meshTissue Scaffolds - chemistry-
dc.titleBioactive borosilicate glass scaffolds: Improvement on the strength of glass-based scaffolds for tissue engineeringen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0957-4530&volume=20&issue=1&spage=365&epage=372&date=2009&atitle=Bioactive+borosilicate+glass+scaffolds:+improvement+on+the+strength+of+glass-based+scaffolds+for+tissue+engineering-
dc.identifier.emailPan, H:haobo@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityPan, H=rp01564en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10856-008-3582-3en_HK
dc.identifier.pmid18807266-
dc.identifier.scopuseid_2-s2.0-58549111980en_HK
dc.identifier.hkuros181279en_HK
dc.identifier.hkuros163516en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58549111980&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue1en_HK
dc.identifier.spage365en_HK
dc.identifier.epage372en_HK
dc.identifier.isiWOS:000262535200043-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, X=25639972700en_HK
dc.identifier.scopusauthoridHuang, W=7407905904en_HK
dc.identifier.scopusauthoridFu, H=15759505300en_HK
dc.identifier.scopusauthoridYao, A=15761582600en_HK
dc.identifier.scopusauthoridWang, D=8334565700en_HK
dc.identifier.scopusauthoridPan, H=7403295092en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK

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