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Article: Supramolecular hydrogel of a D-amino acid dipeptide for controlled drug release in vivo

TitleSupramolecular hydrogel of a D-amino acid dipeptide for controlled drug release in vivo
Authors
Issue Date2009
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/langmuir
Citation
Langmuir, 2009, v. 25 n. 15, p. 8419-8422 How to Cite?
AbstractA supramolecular hydrogel based on D-amino acids, which resists hydrolysis catalyzed by proteinase K and offers long-term biostability, exhibits controlled release in vivo, as proved by the pharmacokinetics of encapsulated 125I tracers and the SPECT imaging of the hydrogel-encapsulated I tracers. As the first in vivo imaging investigation of the drug release properties of the supramolecular hydrogel, isotope encapsulation serves as a valid, useful assay for characterizing the controlled release properties of supramolecular hydrogels in vivo. Our results indicate that supramolecular hydrogels promise new biomaterials for controlled drug release. © 2009 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/125195
ISSN
2015 Impact Factor: 3.993
2015 SCImago Journal Rankings: 1.750
ISI Accession Number ID
Funding AgencyGrant Number
RGC of Hong KongHKU2/05C
604905
600504
EHIA (HKUST)
Funding Information:

This work was partially supported by RGC of Hong Kong (HKU2/05C, 604905, 600504), EHIA (HKUST), and start-up funds (Brandeis). B.X. thanks Professor Ying Chau for helpful suggestions.

References

 

DC FieldValueLanguage
dc.contributor.authorLiang, Gen_HK
dc.contributor.authorYang, Zen_HK
dc.contributor.authorZhang, Ren_HK
dc.contributor.authorLi, Len_HK
dc.contributor.authorFan, Yen_HK
dc.contributor.authorKuang, Yen_HK
dc.contributor.authorGao, Yen_HK
dc.contributor.authorWang, Ten_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorXu, Ben_HK
dc.date.accessioned2010-10-31T11:16:51Z-
dc.date.available2010-10-31T11:16:51Z-
dc.date.issued2009en_HK
dc.identifier.citationLangmuir, 2009, v. 25 n. 15, p. 8419-8422en_HK
dc.identifier.issn0743-7463en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125195-
dc.description.abstractA supramolecular hydrogel based on D-amino acids, which resists hydrolysis catalyzed by proteinase K and offers long-term biostability, exhibits controlled release in vivo, as proved by the pharmacokinetics of encapsulated 125I tracers and the SPECT imaging of the hydrogel-encapsulated I tracers. As the first in vivo imaging investigation of the drug release properties of the supramolecular hydrogel, isotope encapsulation serves as a valid, useful assay for characterizing the controlled release properties of supramolecular hydrogels in vivo. Our results indicate that supramolecular hydrogels promise new biomaterials for controlled drug release. © 2009 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/langmuiren_HK
dc.relation.ispartofLangmuiren_HK
dc.titleSupramolecular hydrogel of a D-amino acid dipeptide for controlled drug release in vivoen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0743-7463&volume=25&issue=15&spage=8419&epage=8422&date=2009&atitle=Supramolecular+Hydrogel+of+a+D-Amino+Acid+Dipeptide+for+Controlled+Drug+Release+in+Vivoen_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/la804271den_HK
dc.identifier.pmid20050040en_HK
dc.identifier.scopuseid_2-s2.0-68149089875en_HK
dc.identifier.hkuros181265en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68149089875&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue15en_HK
dc.identifier.spage8419en_HK
dc.identifier.epage8422en_HK
dc.identifier.isiWOS:000268231500014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiang, G=12244977600en_HK
dc.identifier.scopusauthoridYang, Z=7405429759en_HK
dc.identifier.scopusauthoridZhang, R=7404864740en_HK
dc.identifier.scopusauthoridLi, L=7501447027en_HK
dc.identifier.scopusauthoridFan, Y=35339056500en_HK
dc.identifier.scopusauthoridKuang, Y=8850494400en_HK
dc.identifier.scopusauthoridGao, Y=34770898800en_HK
dc.identifier.scopusauthoridWang, T=7405564863en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridXu, B=24752310700en_HK
dc.identifier.citeulike10616636-

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