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Article: Bioactive borosilicate glass scaffolds: In vitro degradation and bioactivity behaviors

TitleBioactive borosilicate glass scaffolds: In vitro degradation and bioactivity behaviors
Authors
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530
Citation
Journal Of Materials Science: Materials In Medicine, 2009, v. 20 n. 6, p. 1237-1243 How to Cite?
AbstractBioactive borosilicate glass scaffolds with the pores of several hundred micrometers and a competent compressive strength were prepared through replication method. The in vitro degradation and bioactivity behaviors of the scaffolds have been investigated by immersing the scaffolds statically in diluted phosphate solution at 37°C, up to 360 h. To monitor the degradation progress of the scaffolds, the amount of leaching elements from the scaffolds were determined by ICP-AES. The XRD and SEM results reveal that, during the degradation of scaffolds, the borosilicate scaffolds converted to hydroxyapatite. The compressive strength of the scaffolds decreased during degradation, in the way that can be well predicted by the degradation products, or the leachates, from the scaffolds. MTT assay results demonstrate that the degradation products have little, if any, inhibition effect on the cell proliferation, when diluted to a certain concentration ([B] <2.690 and pH value at neutral level). The study shows that borosilicate glass scaffold could be a promising candidate for bone tissue engineering material. © 2009 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/125172
ISSN
2015 Impact Factor: 2.272
2013 SCImago Journal Rankings: 0.897
ISI Accession Number ID
Funding AgencyGrant Number
Science and Technology Commission of Shanghai Municipality, China05DJ14006
08441900500
Hong Kong RGC71437/07E
Funding Information:

This work was supported by the Science and Technology Commission of Shanghai Municipality, China, under Project (Grant No. 05DJ14006) (Grant No. 08441900500) and Hong Kong RGC: 71437/07E.

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorHuang, Wen_HK
dc.contributor.authorFu, Hen_HK
dc.contributor.authorYao, Aen_HK
dc.contributor.authorWang, Den_HK
dc.contributor.authorPan, Hen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorJiang, Xen_HK
dc.contributor.authorZhang, Xen_HK
dc.date.accessioned2010-10-31T11:15:32Z-
dc.date.available2010-10-31T11:15:32Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Materials Science: Materials In Medicine, 2009, v. 20 n. 6, p. 1237-1243en_HK
dc.identifier.issn0957-4530en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125172-
dc.description.abstractBioactive borosilicate glass scaffolds with the pores of several hundred micrometers and a competent compressive strength were prepared through replication method. The in vitro degradation and bioactivity behaviors of the scaffolds have been investigated by immersing the scaffolds statically in diluted phosphate solution at 37°C, up to 360 h. To monitor the degradation progress of the scaffolds, the amount of leaching elements from the scaffolds were determined by ICP-AES. The XRD and SEM results reveal that, during the degradation of scaffolds, the borosilicate scaffolds converted to hydroxyapatite. The compressive strength of the scaffolds decreased during degradation, in the way that can be well predicted by the degradation products, or the leachates, from the scaffolds. MTT assay results demonstrate that the degradation products have little, if any, inhibition effect on the cell proliferation, when diluted to a certain concentration ([B] <2.690 and pH value at neutral level). The study shows that borosilicate glass scaffold could be a promising candidate for bone tissue engineering material. © 2009 Springer Science+Business Media, LLC.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0957-4530en_HK
dc.relation.ispartofJournal of Materials Science: Materials in Medicineen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshBiocompatible Materials - chemistry-
dc.subject.meshBone Substitutes - chemistry-
dc.subject.meshGlass - chemistry-
dc.subject.meshSilicates - chemistry-
dc.subject.meshTissue Scaffolds-
dc.titleBioactive borosilicate glass scaffolds: In vitro degradation and bioactivity behaviorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0957-4530&volume=20&issue=6&spage=1237&epage=1243&date=2009&atitle=Bioactive+borosilicate+glass+scaffolds:+in+vitro+degradation+and+bioactivity+behaviors-
dc.identifier.emailPan, H:haobo@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityPan, H=rp01564en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10856-009-3691-7en_HK
dc.identifier.pmid19184371-
dc.identifier.scopuseid_2-s2.0-67349193784en_HK
dc.identifier.hkuros181272en_HK
dc.identifier.hkuros163515-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349193784&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1237en_HK
dc.identifier.epage1243en_HK
dc.identifier.isiWOS:000265881200005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, X=25639972700en_HK
dc.identifier.scopusauthoridHuang, W=7407905904en_HK
dc.identifier.scopusauthoridFu, H=15759505300en_HK
dc.identifier.scopusauthoridYao, A=15761582600en_HK
dc.identifier.scopusauthoridWang, D=8334565700en_HK
dc.identifier.scopusauthoridPan, H=7403295092en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridJiang, X=7404627219en_HK
dc.identifier.scopusauthoridZhang, X=22939791100en_HK
dc.identifier.citeulike3994688-

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