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Article: Theoretical risk assessment of magnesium alloys as degradable biomedical implants

TitleTheoretical risk assessment of magnesium alloys as degradable biomedical implants
Authors
KeywordsAluminum
Degradable
Metallic implant
Risk assessment
Toxicology
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomat
Citation
Acta Biomaterialia, 2010, v. 6 n. 5, p. 1808-1812 How to Cite?
AbstractThe theoretical tolerable implant masses for ten magnesium alloys as degradable biomedical implant materials are evaluated in this study. Dose-response assessment is conducted using toxicological data from authoritative public health agencies such as the US Agency for Toxic Substances and Disease Registry and the USEPA Integrated Risk Information System, and assuming 1 year of even corrosion. Uncertainty factors adopted by the agencies are used. The tolerable limits corresponding to various component elements in an alloy are considered separately, and the lowest tolerable limit is selected as the tolerable limit of the alloy. The results show that aluminum is usually the component element with the lowest tolerance, and the tolerable mass for Al-containing magnesium alloys fall to around or below 1 g per person per year, while the limit for other magnesium alloys can well exceed 10 g. Deficits in the toxicological data of some component elements are noted. This study illustrates that toxicological calculations should be taken into consideration when developing novel degradable metallic implants. © 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/125164
ISSN
2015 Impact Factor: 6.008
2015 SCImago Journal Rankings: 2.020
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, CKen_HK
dc.contributor.authorIp, WYen_HK
dc.date.accessioned2010-10-31T11:15:06Z-
dc.date.available2010-10-31T11:15:06Z-
dc.date.issued2010en_HK
dc.identifier.citationActa Biomaterialia, 2010, v. 6 n. 5, p. 1808-1812en_HK
dc.identifier.issn1742-7061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125164-
dc.description.abstractThe theoretical tolerable implant masses for ten magnesium alloys as degradable biomedical implant materials are evaluated in this study. Dose-response assessment is conducted using toxicological data from authoritative public health agencies such as the US Agency for Toxic Substances and Disease Registry and the USEPA Integrated Risk Information System, and assuming 1 year of even corrosion. Uncertainty factors adopted by the agencies are used. The tolerable limits corresponding to various component elements in an alloy are considered separately, and the lowest tolerable limit is selected as the tolerable limit of the alloy. The results show that aluminum is usually the component element with the lowest tolerance, and the tolerable mass for Al-containing magnesium alloys fall to around or below 1 g per person per year, while the limit for other magnesium alloys can well exceed 10 g. Deficits in the toxicological data of some component elements are noted. This study illustrates that toxicological calculations should be taken into consideration when developing novel degradable metallic implants. © 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/actabiomaten_HK
dc.relation.ispartofActa Biomaterialiaen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Acta Biomaterialia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Acta Biomaterialia, 2010, v. 6 n. 5, p. 1808-1812. doi:10.1016/j.actbio.2009.11.036-
dc.subjectAluminumen_HK
dc.subjectDegradableen_HK
dc.subjectMetallic implanten_HK
dc.subjectRisk assessmenten_HK
dc.subjectToxicologyen_HK
dc.subject.meshAbsorbable Implants-
dc.subject.meshAlloys - toxicity-
dc.subject.meshBiocompatible Materials - toxicity-
dc.subject.meshMagnesium - toxicity-
dc.subject.meshRisk Assessment-
dc.titleTheoretical risk assessment of magnesium alloys as degradable biomedical implantsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-7061&volume=6&issue=5&spage=1808&epage=1812&date=2010&atitle=Theoretical+risk+assessment+of+magnesium+alloys+as+degradable+biomedical+implants-
dc.identifier.emailIp, WY:wyip@hku.hken_HK
dc.identifier.authorityIp, WY=rp00401en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.actbio.2009.11.036en_HK
dc.identifier.pmid19969109-
dc.identifier.scopuseid_2-s2.0-77954687298en_HK
dc.identifier.hkuros178688en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954687298&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1808en_HK
dc.identifier.epage1812en_HK
dc.identifier.eissn1878-7568-
dc.identifier.isiWOS:000277847500017-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridYuen, CK=25823576300en_HK
dc.identifier.scopusauthoridIp, WY=35549641700en_HK

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