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Article: Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans

TitleIntraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans
Authors
Issue Date2010
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal Of General Virology, 2010, v. 91 n. 4, p. 1058-1062 How to Cite?
AbstractThe Chinese rufous horseshoe bat (Rhinolophus sinicus) has been suggested to carry the direct ancestor of severe acute respiratory syndrome (SARS) coronavirus (SCoV), and the diversity of SARS-like CoVs (SLCoV) within this Rhinolophus species is therefore worth investigating. Here, we demonstrate the remarkable diversity of SLCoVs in R. sinicus and identify a strain with the same pattern of phylogenetic incongruence (i.e. an indication of recombination) as reported previously in another SLCoV strain. Moreover, this strain possesses a distinctive 579 nt deletion in the nsp3 region that was also found in a human SCoV from the late-phase epidemic. Phylogenetic analysis of the Orf1 region suggested that the human SCoVs are phylogenetically closer to SLCoVs in R. sinicus than to SLCoVs in other Rhinolophus species. These findings reveal a closer evolutionary linkage between SCoV in humans and SLCoVs in R. sinicus, defining the scope of surveillance to search for the direct ancestor of human SCoVs. © 2010 SGM.
Persistent Identifierhttp://hdl.handle.net/10722/125151
ISSN
2015 Impact Factor: 3.192
2015 SCImago Journal Rankings: 1.741
ISI Accession Number ID
Funding AgencyGrant Number
Chinese Ministry of Science2005CB523004
2008GR1409
National Natural Science Foundation30970137
Technology and Knowledge Innovation ProgramKSCX1-YW-R-07
Funding Information:

This work was jointly funded by a State Key Program for Basic Research grant (2005CB523004) and the International Cooperation Centre Project (2008GR1409) from the Chinese Ministry of Science, the National Natural Science Foundation (30970137) and the Technology and Knowledge Innovation Program Key Project administered by the Chinese Academy of Sciences (KSCX1-YW-R-07).

References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Jen_HK
dc.contributor.authorHon, CCen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorWang, Den_HK
dc.contributor.authorXu, Gen_HK
dc.contributor.authorZhang, Hen_HK
dc.contributor.authorZhou, Pen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorLam, TTYen_HK
dc.contributor.authorLeung, FCCen_HK
dc.contributor.authorShi, Zen_HK
dc.date.accessioned2010-10-31T11:14:17Z-
dc.date.available2010-10-31T11:14:17Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of General Virology, 2010, v. 91 n. 4, p. 1058-1062en_HK
dc.identifier.issn0022-1317en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125151-
dc.description.abstractThe Chinese rufous horseshoe bat (Rhinolophus sinicus) has been suggested to carry the direct ancestor of severe acute respiratory syndrome (SARS) coronavirus (SCoV), and the diversity of SARS-like CoVs (SLCoV) within this Rhinolophus species is therefore worth investigating. Here, we demonstrate the remarkable diversity of SLCoVs in R. sinicus and identify a strain with the same pattern of phylogenetic incongruence (i.e. an indication of recombination) as reported previously in another SLCoV strain. Moreover, this strain possesses a distinctive 579 nt deletion in the nsp3 region that was also found in a human SCoV from the late-phase epidemic. Phylogenetic analysis of the Orf1 region suggested that the human SCoVs are phylogenetically closer to SLCoVs in R. sinicus than to SLCoVs in other Rhinolophus species. These findings reveal a closer evolutionary linkage between SCoV in humans and SLCoVs in R. sinicus, defining the scope of surveillance to search for the direct ancestor of human SCoVs. © 2010 SGM.en_HK
dc.languageengen_HK
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.orgen_HK
dc.relation.ispartofJournal of General Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of General Virology. Copyright © Society for General Microbiology.-
dc.rightsThis is an author manuscript that has been accepted for publication in Journal of General Virology, copyright Society for General Microbiology, but has not been copy-edited, formatted or proofed. Cite this article as appearing in Journal of General Virology. This version of the manuscript may not be duplicated or reproduced, other than for personal use or within the rule of 'Fair Use of Copyrighted Materials' (section 17, Title 17, US Code), without permission from the copyright owner, Society for General Microbiology. The Society for General Microbiology disclaims any responsibility or liability for errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final copy-edited, published article, which is the version of record, can be found at http://vir.sgmjournals.org, and is freely available without a subscription.-
dc.subject.meshAnimals-
dc.subject.meshBase Sequence-
dc.subject.meshChiroptera - virology-
dc.subject.meshPhylogeny-
dc.subject.meshSARS Virus - classification - genetics-
dc.titleIntraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1317&volume=91&issue=4&spage=1058&epage=1062&date=2009&atitle=Intraspecies+diversity+of+SARS-like+coronaviruses+in+Rhinolophus+sinicus+and+its+implications+for+the+origin+of+SARS+coronaviruses+in+humansen_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailLam, TTY: ttylam@hku.hken_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityLam, TTY=rp01733en_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1099/vir.0.016378-0en_HK
dc.identifier.pmid20016037-
dc.identifier.scopuseid_2-s2.0-77949532150en_HK
dc.identifier.hkuros176296en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949532150&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1058en_HK
dc.identifier.epage1062en_HK
dc.identifier.isiWOS:000276714300026-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuan, J=14065620600en_HK
dc.identifier.scopusauthoridHon, CC=7003617137en_HK
dc.identifier.scopusauthoridLi, Y=36079617800en_HK
dc.identifier.scopusauthoridWang, D=14061500300en_HK
dc.identifier.scopusauthoridXu, G=14049536200en_HK
dc.identifier.scopusauthoridZhang, H=35749213000en_HK
dc.identifier.scopusauthoridZhou, P=7401848795en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridLam, TTY=36775821700en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK
dc.identifier.scopusauthoridShi, Z=7403733955en_HK

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