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Article: Evaluation of a subunit H5 vaccine and an inactivated H5n2 avian influenza marker vaccine in ducks challenged with Vietnamese H5n1 Highly pathogenic avian influenza virus

TitleEvaluation of a subunit H5 vaccine and an inactivated H5n2 avian influenza marker vaccine in ducks challenged with Vietnamese H5n1 Highly pathogenic avian influenza virus
Authors
KeywordsMedical sciences
Communicable diseases
Issue Date2010
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/irt
Citation
Influenza Research and Treatment, 2010, v. 2010 n. article no. 489213 How to Cite?
AbstractThe protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks. Antibody responses, morbidity, mortality, and virus shedding were evaluated after challenge with a Vietnamese clade 1 H5N1 HPAI virus [A/VN/1203/04 (H5N1)] that was known to cause a high mortality rate in ducks. All three vaccines, administered with water-in-oil adjuvant, provided significant protection and dramatically reduced the duration and titer of virus shedding in the vaccinated challenged ducks compared with unvaccinated controls. The H5 subunit vaccine was shown to provide equivalent protection to the other two vaccines despite the H5 antibody responses in subunit vaccinated ducks being significantly lower prior to challenge. Ducks vaccinated with the H5N2 marker vaccine consistently produced antitetanus toxoid antibody. The two novel vaccines have attributes that would enhance H5N1 avian influenza surveillance and control by vaccination in small scale and village poultry systems.
Persistent Identifierhttp://hdl.handle.net/10722/125149
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChua, THen_HK
dc.contributor.authorLeung, CYHen_HK
dc.contributor.authorFang, HEen_HK
dc.contributor.authorChow, CKen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorSia, SFen_HK
dc.contributor.authorNg, IHYen_HK
dc.contributor.authorFenwick, SGen_HK
dc.contributor.authorJames, CMen_HK
dc.contributor.authorChua, SBen_HK
dc.contributor.authorChew, STen_HK
dc.contributor.authorKwang, Jen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorEllis, TMen_HK
dc.date.accessioned2010-10-31T11:14:10Z-
dc.date.available2010-10-31T11:14:10Z-
dc.date.issued2010en_HK
dc.identifier.citationInfluenza Research and Treatment, 2010, v. 2010 n. article no. 489213en_HK
dc.identifier.issn2090-1380-
dc.identifier.urihttp://hdl.handle.net/10722/125149-
dc.description.abstractThe protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks. Antibody responses, morbidity, mortality, and virus shedding were evaluated after challenge with a Vietnamese clade 1 H5N1 HPAI virus [A/VN/1203/04 (H5N1)] that was known to cause a high mortality rate in ducks. All three vaccines, administered with water-in-oil adjuvant, provided significant protection and dramatically reduced the duration and titer of virus shedding in the vaccinated challenged ducks compared with unvaccinated controls. The H5 subunit vaccine was shown to provide equivalent protection to the other two vaccines despite the H5 antibody responses in subunit vaccinated ducks being significantly lower prior to challenge. Ducks vaccinated with the H5N2 marker vaccine consistently produced antitetanus toxoid antibody. The two novel vaccines have attributes that would enhance H5N1 avian influenza surveillance and control by vaccination in small scale and village poultry systems.-
dc.languageengen_HK
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/irten_HK
dc.relation.ispartofInfluenza Research and Treatmenten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciences-
dc.subjectCommunicable diseases-
dc.titleEvaluation of a subunit H5 vaccine and an inactivated H5n2 avian influenza marker vaccine in ducks challenged with Vietnamese H5n1 Highly pathogenic avian influenza virusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=2090-1380&volume=2010 &issue=article no. 489213&spage=&epage=&date=2010&atitle=Evaluation+of+a+subunit+H5+vaccine+and+an+inactivated+H5n2+avian+influenza+marker+vaccine+in+ducks+challenged+with+Vietnamese+H5n1+Highly+pathogenic+avian+influenza+virus-
dc.identifier.emailLeung, CYH: cyhleung@hkucc.hku.hken_HK
dc.identifier.emailChow, CK: isaac@hkgolden.comen_HK
dc.identifier.emailMa, SK: mask@HKUCC.hku.hk, edward_ma@hotmail.comen_HK
dc.identifier.emailSia, SF: sfsia@HKUCC.hku.hken_HK
dc.identifier.emailNg, IHY: ihyng@HKUCC.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailEllis, TM: t.ellis@murdoch.edu.au-
dc.identifier.authorityLeung, CYH=rp00307en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2010/489213-
dc.identifier.hkuros173496en_HK
dc.identifier.volume2010en_HK
dc.identifier.issuearticle no. 489213-

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