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Article: Evaluation of a subunit H5 vaccine and an inactivated H5n2 avian influenza marker vaccine in ducks challenged with Vietnamese H5n1 Highly pathogenic avian influenza virus
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TitleEvaluation of a subunit H5 vaccine and an inactivated H5n2 avian influenza marker vaccine in ducks challenged with Vietnamese H5n1 Highly pathogenic avian influenza virus
 
AuthorsChua, TH
Leung, CYH
Fang, HE
Chow, CK
Ma, SK
Sia, SF
Ng, IHY
Fenwick, SG
James, CM
Chua, SB
Chew, ST
Kwang, J
Peiris, JSM
Ellis, TM
 
KeywordsMedical sciences
Communicable diseases
 
Issue Date2010
 
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/irt
 
CitationInfluenza Research and Treatment, 2010, v. 2010 n. article no. 489213 [How to Cite?]
DOI: http://dx.doi.org/10.1155/2010/489213
 
AbstractThe protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks. Antibody responses, morbidity, mortality, and virus shedding were evaluated after challenge with a Vietnamese clade 1 H5N1 HPAI virus [A/VN/1203/04 (H5N1)] that was known to cause a high mortality rate in ducks. All three vaccines, administered with water-in-oil adjuvant, provided significant protection and dramatically reduced the duration and titer of virus shedding in the vaccinated challenged ducks compared with unvaccinated controls. The H5 subunit vaccine was shown to provide equivalent protection to the other two vaccines despite the H5 antibody responses in subunit vaccinated ducks being significantly lower prior to challenge. Ducks vaccinated with the H5N2 marker vaccine consistently produced antitetanus toxoid antibody. The two novel vaccines have attributes that would enhance H5N1 avian influenza surveillance and control by vaccination in small scale and village poultry systems.
 
ISSN2090-1380
 
DOIhttp://dx.doi.org/10.1155/2010/489213
 
DC FieldValue
dc.contributor.authorChua, TH
 
dc.contributor.authorLeung, CYH
 
dc.contributor.authorFang, HE
 
dc.contributor.authorChow, CK
 
dc.contributor.authorMa, SK
 
dc.contributor.authorSia, SF
 
dc.contributor.authorNg, IHY
 
dc.contributor.authorFenwick, SG
 
dc.contributor.authorJames, CM
 
dc.contributor.authorChua, SB
 
dc.contributor.authorChew, ST
 
dc.contributor.authorKwang, J
 
dc.contributor.authorPeiris, JSM
 
dc.contributor.authorEllis, TM
 
dc.date.accessioned2010-10-31T11:14:10Z
 
dc.date.available2010-10-31T11:14:10Z
 
dc.date.issued2010
 
dc.description.abstractThe protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks. Antibody responses, morbidity, mortality, and virus shedding were evaluated after challenge with a Vietnamese clade 1 H5N1 HPAI virus [A/VN/1203/04 (H5N1)] that was known to cause a high mortality rate in ducks. All three vaccines, administered with water-in-oil adjuvant, provided significant protection and dramatically reduced the duration and titer of virus shedding in the vaccinated challenged ducks compared with unvaccinated controls. The H5 subunit vaccine was shown to provide equivalent protection to the other two vaccines despite the H5 antibody responses in subunit vaccinated ducks being significantly lower prior to challenge. Ducks vaccinated with the H5N2 marker vaccine consistently produced antitetanus toxoid antibody. The two novel vaccines have attributes that would enhance H5N1 avian influenza surveillance and control by vaccination in small scale and village poultry systems.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationInfluenza Research and Treatment, 2010, v. 2010 n. article no. 489213 [How to Cite?]
DOI: http://dx.doi.org/10.1155/2010/489213
 
dc.identifier.doihttp://dx.doi.org/10.1155/2010/489213
 
dc.identifier.hkuros173496
 
dc.identifier.issn2090-1380
 
dc.identifier.issuearticle no. 489213
 
dc.identifier.openurl
 
dc.identifier.urihttp://hdl.handle.net/10722/125149
 
dc.identifier.volume2010
 
dc.languageeng
 
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/irt
 
dc.relation.ispartofInfluenza Research and Treatment
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectMedical sciences
 
dc.subjectCommunicable diseases
 
dc.titleEvaluation of a subunit H5 vaccine and an inactivated H5n2 avian influenza marker vaccine in ducks challenged with Vietnamese H5n1 Highly pathogenic avian influenza virus
 
dc.typeArticle
 
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