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Article: 2009 Pandemic H1N1 Influenza virus replicates in human lung tissues

Title2009 Pandemic H1N1 Influenza virus replicates in human lung tissues
Authors
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2010, v. 201 n. 10, p. 1522-1526 How to Cite?
AbstractThe replication activity of 2009 pandemic H1N1 influenza virus in human lung cells was evaluated in this study. Twenty-two surgically removed human lung tissue samples were infected ex vivo with pandemic H1N1 influenza virus (A/California/04/2009), seasonal human H1N1 influenza virus (A/ Shantou/92/09), or a highly pathogenic H5N1 influenza virus (A/Vietnam/1194/04). Examination of nucleoprotein expression and viral RNA replication in the infected human lung tissue samples showed that whereas the replication of pandemic H1N1 influenza virus varied between tissue samples, overall this virus replicated more efficiently than seasonal H1N1 influenza virus but less efficiently than H5N1 influenza virus. Double-immunostaining for viral antigens and cellular markers indicated that pandemic H1N1 influenza virus replicates in type 2 alveolar epithelial cells. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/125144
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Special Administrative Region (SAR), ChinaHKU 74888/05M
7500/06M
Area of Excellence Scheme of the University Grants CommitteeAoE/M-12/06
National Institutes of Health, United StatesHHSN2662007 00005C
Research Fund for the Control of Infectious Diseases of the Health, Welfare and Food Bureau of the Hong Kong SAR
Li Ka Shing Foundation
Funding Information:

Research Grants Council of the Hong Kong Special Administrative Region (SAR), China (grants HKU 74888/05M and 7500/06M); Area of Excellence Scheme of the University Grants Committee (grant AoE/M-12/06); National Institutes of Health, United States (contract HHSN2662007 00005C); Research Fund for the Control of Infectious Diseases of the Health, Welfare and Food Bureau of the Hong Kong SAR; Li Ka Shing Foundation.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorFan, Xen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorZheng, Zen_HK
dc.contributor.authorChen, Ren_HK
dc.contributor.authorWang, Pen_HK
dc.contributor.authorSong, Wen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-10-31T11:13:53Z-
dc.date.available2010-10-31T11:13:53Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2010, v. 201 n. 10, p. 1522-1526en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125144-
dc.description.abstractThe replication activity of 2009 pandemic H1N1 influenza virus in human lung cells was evaluated in this study. Twenty-two surgically removed human lung tissue samples were infected ex vivo with pandemic H1N1 influenza virus (A/California/04/2009), seasonal human H1N1 influenza virus (A/ Shantou/92/09), or a highly pathogenic H5N1 influenza virus (A/Vietnam/1194/04). Examination of nucleoprotein expression and viral RNA replication in the infected human lung tissue samples showed that whereas the replication of pandemic H1N1 influenza virus varied between tissue samples, overall this virus replicated more efficiently than seasonal H1N1 influenza virus but less efficiently than H5N1 influenza virus. Double-immunostaining for viral antigens and cellular markers indicated that pandemic H1N1 influenza virus replicates in type 2 alveolar epithelial cells. © 2010 by the Infectious Diseases Society of America. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org en_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.title2009 Pandemic H1N1 Influenza virus replicates in human lung tissuesen_HK
dc.typeArticleen_HK
dc.identifier.emailZhang, J: zhangajx@hkucc.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityZhang, J=rp00413en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1086/650544en_HK
dc.identifier.scopuseid_2-s2.0-77951888729en_HK
dc.identifier.hkuros180274en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951888729&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume201en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1522en_HK
dc.identifier.epage1526en_HK
dc.identifier.isiWOS:000276767600012-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridZhang, J=12752135600en_HK
dc.identifier.scopusauthoridZhang, Z=25930204600en_HK
dc.identifier.scopusauthoridFan, X=35227217200en_HK
dc.identifier.scopusauthoridLiu, Y=36059593000en_HK
dc.identifier.scopusauthoridWang, J=35228130300en_HK
dc.identifier.scopusauthoridZheng, Z=35747739800en_HK
dc.identifier.scopusauthoridChen, R=35745563500en_HK
dc.identifier.scopusauthoridWang, P=13907209900en_HK
dc.identifier.scopusauthoridSong, W=23490429800en_HK
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.citeulike6973106-

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