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Article: The prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccine

TitleThe prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccine
Authors
KeywordsDrug resistance
Prevalence
Serotype
Streptococcus pneumoniae
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio
Citation
Diagnostic Microbiology And Infectious Disease, 2010, v. 68 n. 4, p. 439-444 How to Cite?
AbstractA study was conducted to determine the prevalence of the 2 newly described types, 6C and 6D, among pneumococcal isolates collected in Hong Kong before availability of the 7-valent pneumococcal conjugate vaccine. A total of 154 serogroup 6 isolates obtained from nasopharynx (n = 106), blood (n = 22), respiratory (n = 24), and cerebrospinal fluid (CSF) (n = 2) during 1995 to 2001 were analyzed by polymerase chain reaction typing. Five nasopharyngeal and 2 sputum isolates were found to belong to 6C and 6D, respectively. The isolates were genetically diverse, but one 6C and two 6D isolates exhibited some clonal relationship. Phylogenetic analysis of the wchA-wciN ?-wciO nucleotide sequences showed that the Hong Kong 6C/6D isolates had 2 allelic profiles, which were more closely related to 6C/6D isolates from Fijian and Korea than were those from Brazil and the United States. However, all of the wciP gene sequences for both Hong Kong and non-Hong Kong isolates clustered together: 6C isolates with the wciP-9 allele and 6D isolates with the wciP-5 allele. In conclusion, the prevalence of the 2 newly described serotypes was low before the era of the pneumococcal conjugate vaccine. Nonetheless, results from the molecular studies indicated that the evolution of the capsular genes have involved complex pathways. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/125141
ISSN
2015 Impact Factor: 2.45
2015 SCImago Journal Rankings: 1.142
ISI Accession Number ID
Funding AgencyGrant Number
Research Fund for the Control of Infectious Diseases of the Health and Food Bureau of the Hong Kong SAR Government
Funding Information:

This study is supported by research grants from the Research Fund for the Control of Infectious Diseases of the Health and Food Bureau of the Hong Kong SAR Government Authors had no conflict of interest to declare

References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorAng, Ien_HK
dc.contributor.authorChow, KHen_HK
dc.contributor.authorLai, ELen_HK
dc.contributor.authorChiu, SSen_HK
dc.date.accessioned2010-10-31T11:13:43Z-
dc.date.available2010-10-31T11:13:43Z-
dc.date.issued2010en_HK
dc.identifier.citationDiagnostic Microbiology And Infectious Disease, 2010, v. 68 n. 4, p. 439-444en_HK
dc.identifier.issn0732-8893en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125141-
dc.description.abstractA study was conducted to determine the prevalence of the 2 newly described types, 6C and 6D, among pneumococcal isolates collected in Hong Kong before availability of the 7-valent pneumococcal conjugate vaccine. A total of 154 serogroup 6 isolates obtained from nasopharynx (n = 106), blood (n = 22), respiratory (n = 24), and cerebrospinal fluid (CSF) (n = 2) during 1995 to 2001 were analyzed by polymerase chain reaction typing. Five nasopharyngeal and 2 sputum isolates were found to belong to 6C and 6D, respectively. The isolates were genetically diverse, but one 6C and two 6D isolates exhibited some clonal relationship. Phylogenetic analysis of the wchA-wciN ?-wciO nucleotide sequences showed that the Hong Kong 6C/6D isolates had 2 allelic profiles, which were more closely related to 6C/6D isolates from Fijian and Korea than were those from Brazil and the United States. However, all of the wciP gene sequences for both Hong Kong and non-Hong Kong isolates clustered together: 6C isolates with the wciP-9 allele and 6D isolates with the wciP-5 allele. In conclusion, the prevalence of the 2 newly described serotypes was low before the era of the pneumococcal conjugate vaccine. Nonetheless, results from the molecular studies indicated that the evolution of the capsular genes have involved complex pathways. © 2010 Elsevier Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobioen_HK
dc.relation.ispartofDiagnostic Microbiology and Infectious Diseaseen_HK
dc.subjectDrug resistanceen_HK
dc.subjectPrevalenceen_HK
dc.subjectSerotypeen_HK
dc.subjectStreptococcus pneumoniaeen_HK
dc.titleThe prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccineen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0732-8893&volume=68&issue=4&spage=439&epage=444&date=2010&atitle=The+prevalence+and+characteristics+of+Streptococcus+pneumoniae+isolates+expressing+serotypes+6C+and+6D+in+Hong+Kong+prior+to+the+introduction+of+the+7-valent+pneumococcal+conjugate+vaccineen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailChow, KH:khchowb@hku.hken_HK
dc.identifier.emailChiu, SS:ssschiu@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityChow, KH=rp00370en_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.diagmicrobio.2010.07.020en_HK
dc.identifier.pmid20926218-
dc.identifier.scopuseid_2-s2.0-78649317146en_HK
dc.identifier.hkuros175976en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649317146&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue4en_HK
dc.identifier.spage439en_HK
dc.identifier.epage444en_HK
dc.identifier.isiWOS:000285031700015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridAng, I=55214129400en_HK
dc.identifier.scopusauthoridChow, KH=7202180736en_HK
dc.identifier.scopusauthoridLai, EL=8238477100en_HK
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK
dc.identifier.citeulike7972813-

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