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Article: Highly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profile

TitleHighly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profile
Authors
Issue Date2010
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jmc
Citation
Journal Of Medicinal Chemistry, 2010, v. 53 n. 3, p. 1397-1401 How to Cite?
AbstractWe herein report a new compound: 10-chloromethyl-11-demethyl-12-oxo- calanolide A (20, EC 50 = 7.4 nM, SI = 1417), which demonstrates a druggable profile with 32.7% oral bioavailability in rat, tolerated oral single dose toxicity in mice, and especially the feature of highly efficient suppression of the wild-type HIV-1 and Y181C mutant HIV-1 at an EC 50 = 7.4 nM and EC 50 = 0.46 nM, respectively. © 2010 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/125128
ISSN
2015 Impact Factor: 5.589
2015 SCImago Journal Rankings: 2.529
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China90713045
National 863 Program of China2006AA020501
HKU-UDF
HKSARGFHB/RFCID09080772
Funding Information:

This research is supported financially by the National Natural Science Foundation of China (No, 90713045) and the National 863 Program of China, No.2006AA020501. We thank HKU-UDF and HKSARG FHB/RFCID09080772 for partial funding support of this study. We are also grateful to Mr. Jinfeng Wei for his assistance of single dose toxicity measurement.

References

 

DC FieldValueLanguage
dc.contributor.authorXue, Hen_HK
dc.contributor.authorLu, Xen_HK
dc.contributor.authorZheng, Pen_HK
dc.contributor.authorLiu, Len_HK
dc.contributor.authorHan, Cen_HK
dc.contributor.authorHu, Jen_HK
dc.contributor.authorLiu, Zen_HK
dc.contributor.authorMa, Ten_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorChen, Zen_HK
dc.contributor.authorLiu, Gen_HK
dc.date.accessioned2010-10-31T11:12:58Z-
dc.date.available2010-10-31T11:12:58Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Medicinal Chemistry, 2010, v. 53 n. 3, p. 1397-1401en_HK
dc.identifier.issn0022-2623en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125128-
dc.description.abstractWe herein report a new compound: 10-chloromethyl-11-demethyl-12-oxo- calanolide A (20, EC 50 = 7.4 nM, SI = 1417), which demonstrates a druggable profile with 32.7% oral bioavailability in rat, tolerated oral single dose toxicity in mice, and especially the feature of highly efficient suppression of the wild-type HIV-1 and Y181C mutant HIV-1 at an EC 50 = 7.4 nM and EC 50 = 0.46 nM, respectively. © 2010 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/jmcen_HK
dc.relation.ispartofJournal of Medicinal Chemistryen_HK
dc.subject.meshAnti-HIV Agents - chemical synthesis - chemistry - pharmacology-
dc.subject.meshHIV Infections - drug therapy - genetics-
dc.subject.meshHIV-1 - drug effects - genetics-
dc.subject.meshPyranocoumarins - chemical synthesis - chemistry - pharmacology-
dc.subject.meshVirus Replication - drug effects - genetics-
dc.titleHighly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profileen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2623&volume=53&issue=3&spage=1397&epage=1401&date=2010&atitle=Highly+suppressing+wild-type+HIV-1+and+Y181C+mutant+HIV-1+strains+by+10-chloromethyl-11-demethyl-12-oxo-calanolide+A+with+druggable+profile-
dc.identifier.emailLiu, L: liuli71@hkucc.hku.hken_HK
dc.identifier.emailChen, Z: zchenai@hku.hken_HK
dc.identifier.authorityLiu, L=rp00268en_HK
dc.identifier.authorityChen, Z=rp00243en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/jm901653een_HK
dc.identifier.pmid20050672-
dc.identifier.scopuseid_2-s2.0-77249123906en_HK
dc.identifier.hkuros175959en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77249123906&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage1397en_HK
dc.identifier.epage1401en_HK
dc.identifier.isiWOS:000274270900045-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXue, H=35084707100en_HK
dc.identifier.scopusauthoridLu, X=35215493700en_HK
dc.identifier.scopusauthoridZheng, P=35764140600en_HK
dc.identifier.scopusauthoridLiu, L=35784425200en_HK
dc.identifier.scopusauthoridHan, C=17345759200en_HK
dc.identifier.scopusauthoridHu, J=23970787600en_HK
dc.identifier.scopusauthoridLiu, Z=35215529100en_HK
dc.identifier.scopusauthoridMa, T=35763830600en_HK
dc.identifier.scopusauthoridLi, Y=35187394200en_HK
dc.identifier.scopusauthoridWang, L=15836048000en_HK
dc.identifier.scopusauthoridChen, Z=35271180800en_HK
dc.identifier.scopusauthoridLiu, G=36077582900en_HK

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