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Article: An exploratory study on the social and genotypic clustering of HIV infection in men having sex with men

TitleAn exploratory study on the social and genotypic clustering of HIV infection in men having sex with men
Authors
KeywordsCluster
Men having sex with men
Phylogenetic
Social network
Issue Date2009
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.AIDSonline.com
Citation
Aids, 2009, v. 23 n. 13, p. 1755-1764 How to Cite?
AbstractOBJECTIVE: To explore the clustering of HIV infected men having sex with men (MSM) using social network approach in conjunction with the phylogenetic relationship of the virus strains. DESIGN: An exploratory study incorporating social network and phylogenetic analysis. METHODS: Recently diagnosed HIV-infected MSM attending one major HIV specialist clinic in Hong Kong were recruited in the study involving the administration of a self-administered questionnaire on behaviours and partnership patterns using a Likert Scale, the results of which were assessed using social network analysis and in context of the phylogenetic analysis from sequencing the HIV-1 pol gene, as part of the clinical investigation for genotypic resistance. Clusters were defined using social and molecular methods. RESULTS: An 'Internet-centred' cluster and 'Sauna-centred' cluster could be delineated using correspondence analysis and network diagrams. The main distinguishing features of MSM in the 'Internet-centred' social cluster were: younger age, higher education level, and multiple partner types. Three genetic clusters could be identified in the phylogenetic tree, two of which associated with Internet use and one with sauna for sex partnership. There were partial overlaps between social and genetic clusters. Characteristically, the virus strains in sauna users were more disperse compared with the closely knit configuration of those using Internet. CONCLUSION: The principle of the duality of place and person can be strategically applied in epidemiologic investigation. The characterization of MSM cluster using anonymized network data provides a potentially powerful tool for informing public health intervention. © 2009 Lippincott Williams & Wilkins, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/125127
ISSN
2015 Impact Factor: 4.407
2015 SCImago Journal Rankings: 3.112
ISI Accession Number ID
Funding AgencyGrant Number
AIDS Trust Fund of the Hong Kong Special Administrative
Funding Information:

The authors thank all patients at the Integrated Treatment Centre for consenting to participate in the Study, and all nursing and medical staff for their assistance in the conduction of the study. The social network-based studies (SPF-004) and the genotype resistance testing studies (MSS-099R) were supported by the AIDS Trust Fund of the Hong Kong Special Administrative: Region Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorLee, SSen_HK
dc.contributor.authorTam, DKPen_HK
dc.contributor.authorTan, Yen_HK
dc.contributor.authorMak, WLen_HK
dc.contributor.authorWong, KHen_HK
dc.contributor.authorChen, JHKen_HK
dc.contributor.authorYam, WCen_HK
dc.date.accessioned2010-10-31T11:12:55Z-
dc.date.available2010-10-31T11:12:55Z-
dc.date.issued2009en_HK
dc.identifier.citationAids, 2009, v. 23 n. 13, p. 1755-1764en_HK
dc.identifier.issn0269-9370en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125127-
dc.description.abstractOBJECTIVE: To explore the clustering of HIV infected men having sex with men (MSM) using social network approach in conjunction with the phylogenetic relationship of the virus strains. DESIGN: An exploratory study incorporating social network and phylogenetic analysis. METHODS: Recently diagnosed HIV-infected MSM attending one major HIV specialist clinic in Hong Kong were recruited in the study involving the administration of a self-administered questionnaire on behaviours and partnership patterns using a Likert Scale, the results of which were assessed using social network analysis and in context of the phylogenetic analysis from sequencing the HIV-1 pol gene, as part of the clinical investigation for genotypic resistance. Clusters were defined using social and molecular methods. RESULTS: An 'Internet-centred' cluster and 'Sauna-centred' cluster could be delineated using correspondence analysis and network diagrams. The main distinguishing features of MSM in the 'Internet-centred' social cluster were: younger age, higher education level, and multiple partner types. Three genetic clusters could be identified in the phylogenetic tree, two of which associated with Internet use and one with sauna for sex partnership. There were partial overlaps between social and genetic clusters. Characteristically, the virus strains in sauna users were more disperse compared with the closely knit configuration of those using Internet. CONCLUSION: The principle of the duality of place and person can be strategically applied in epidemiologic investigation. The characterization of MSM cluster using anonymized network data provides a potentially powerful tool for informing public health intervention. © 2009 Lippincott Williams & Wilkins, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.AIDSonline.comen_HK
dc.relation.ispartofAIDSen_HK
dc.rightsThis is a non-final version of an article published in final form in AIDS, 2009, v. 23 n. 13, p. 1755-1764-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsAIDS. Copyright © Lippincott Williams & Wilkins.-
dc.subjectClusteren_HK
dc.subjectMen having sex with menen_HK
dc.subjectPhylogeneticen_HK
dc.subjectSocial networken_HK
dc.subject.meshCluster Analysis-
dc.subject.meshHIV Infections - transmission - virology-
dc.subject.meshHIV-1 - classification - genetics - isolation and purification-
dc.subject.meshHomosexuality, Male - statistics and numerical data-
dc.subject.meshSexual Behavior - statistics and numerical data-
dc.titleAn exploratory study on the social and genotypic clustering of HIV infection in men having sex with menen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-9370&volume=23&issue=13&spage=1755&epage=1764&date=2009&atitle=An+exploratory+study+on+the+social+and+genotypic+clustering+of+HIV+infection+in+men+having+sex+with+menen_HK
dc.identifier.emailYam, WC:wcyam@hkucc.hku.hken_HK
dc.identifier.authorityYam, WC=rp00313en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1097/QAD.0b013e32832dc025en_HK
dc.identifier.pmid19609202-
dc.identifier.scopuseid_2-s2.0-69449091132en_HK
dc.identifier.hkuros179897en_HK
dc.identifier.hkuros163017-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69449091132&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue13en_HK
dc.identifier.spage1755en_HK
dc.identifier.epage1764en_HK
dc.identifier.isiWOS:000269333900016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, SS=7601394467en_HK
dc.identifier.scopusauthoridTam, DKP=22136533500en_HK
dc.identifier.scopusauthoridTan, Y=35312605500en_HK
dc.identifier.scopusauthoridMak, WL=35311375200en_HK
dc.identifier.scopusauthoridWong, KH=7404758411en_HK
dc.identifier.scopusauthoridChen, JHK=35085819900en_HK
dc.identifier.scopusauthoridYam, WC=7004281720en_HK
dc.identifier.citeulike6015848-

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