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Article: Human enterovirus 71 and hand, foot and mouth disease

TitleHuman enterovirus 71 and hand, foot and mouth disease
Authors
Keywordsenterovirus
enterovirus 71
foot and mouth disease
Hand
Issue Date2010
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
Citation
Epidemiology And Infection, 2010, v. 138 n. 8, p. 1071-1089 How to Cite?
AbstractHand, foot and mouth disease (HFMD) is generally a benign febrile exanthematous childhood disease caused by human enteroviruses. The route of transmission is postulated to be faeco-oral in developing areas but attributed more to respiratory droplet in developed areas. Transmission is facilitated by the prolonged environmental survival of these viruses and their greater resistance to biocides. Serious outbreaks with neurological and cardiopulmonary complications caused by human enterovirus 71 (HEV-71) seem to be commoner in the Asian Pacific region than elsewhere in the world. This geographical predilection is unexplained but could be related to the frequency of intra- and inter-typic genetic recombinations of the virus, the host populations' genetic predisposition, environmental hygiene, and standard of healthcare. Vaccine development could be hampered by the general mildness of the illness and rapid genetic evolution of the virus. Antivirals are not readily available; the role of intravenous immunoglobulin in the treatment of serious complications should be investigated. Monitoring of this disease and its epidemiology in the densely populated Asia Pacific epicentre is important for the detection of emerging epidemics due to enteroviruses. Copyright © 2010 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/125123
ISSN
2015 Impact Factor: 2.515
2015 SCImago Journal Rankings: 1.320
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Ms Teresa On-Yik Wong
Providence Foundation Limited
Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

The authors acknowledge funding from the University Development Fund 2001-2002 (first round) of The University of Hong Kong, Clinical Infectious Diseases Research Endowment Fund from Ms Teresa On-Yik Wong, Providence Foundation Limited in memory of the late Dr Lui Hac Minh, Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau of the Hong Kong SAR Government.

References

 

DC FieldValueLanguage
dc.contributor.authorWong, SSYen_HK
dc.contributor.authorYip, CCYen_HK
dc.contributor.authorLau, SKPen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-10-31T11:12:41Z-
dc.date.available2010-10-31T11:12:41Z-
dc.date.issued2010en_HK
dc.identifier.citationEpidemiology And Infection, 2010, v. 138 n. 8, p. 1071-1089en_HK
dc.identifier.issn0950-2688en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125123-
dc.description.abstractHand, foot and mouth disease (HFMD) is generally a benign febrile exanthematous childhood disease caused by human enteroviruses. The route of transmission is postulated to be faeco-oral in developing areas but attributed more to respiratory droplet in developed areas. Transmission is facilitated by the prolonged environmental survival of these viruses and their greater resistance to biocides. Serious outbreaks with neurological and cardiopulmonary complications caused by human enterovirus 71 (HEV-71) seem to be commoner in the Asian Pacific region than elsewhere in the world. This geographical predilection is unexplained but could be related to the frequency of intra- and inter-typic genetic recombinations of the virus, the host populations' genetic predisposition, environmental hygiene, and standard of healthcare. Vaccine development could be hampered by the general mildness of the illness and rapid genetic evolution of the virus. Antivirals are not readily available; the role of intravenous immunoglobulin in the treatment of serious complications should be investigated. Monitoring of this disease and its epidemiology in the densely populated Asia Pacific epicentre is important for the detection of emerging epidemics due to enteroviruses. Copyright © 2010 Cambridge University Press.en_HK
dc.languageengen_HK
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYGen_HK
dc.relation.ispartofEpidemiology and Infectionen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectenterovirusen_HK
dc.subjectenterovirus 71en_HK
dc.subjectfoot and mouth diseaseen_HK
dc.subjectHanden_HK
dc.titleHuman enterovirus 71 and hand, foot and mouth diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-2688&volume=138&spage=1071&epage=1089&date=2010&atitle=Human+enterovirus+71+and+hand,+foot+and+mouth+diseaseen_HK
dc.identifier.emailWong, SSY: samsonsy@hkucc.hku.hken_HK
dc.identifier.emailYip, CCY: yipcyril@hku.hken_HK
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityWong, SSY=rp00395en_HK
dc.identifier.authorityYip, CCY=rp01721en_HK
dc.identifier.authorityLau, SKP=rp00486en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1017/S0950268809991555en_HK
dc.identifier.scopuseid_2-s2.0-77954931134en_HK
dc.identifier.hkuros179553en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954931134&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume138en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1071en_HK
dc.identifier.epage1089en_HK
dc.identifier.isiWOS:000280136700001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, SSY=13310021400en_HK
dc.identifier.scopusauthoridYip, CCY=14016999800en_HK
dc.identifier.scopusauthoridLau, SKP=7401596211en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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