Article: Human enterovirus 71 and hand, foot and mouth disease

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TitleHuman enterovirus 71 and hand, foot and mouth disease
AuthorsWong, SSY1
Yip, CCY1
Lau, SKP1
Yuen, KY1
Keywordsenterovirus
enterovirus 71
foot and mouth disease
Hand
Issue Date2010
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
CitationEpidemiology And Infection, 2010, v. 138 n. 8, p. 1071-1089 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0950268809991555
AbstractHand, foot and mouth disease (HFMD) is generally a benign febrile exanthematous childhood disease caused by human enteroviruses. The route of transmission is postulated to be faeco-oral in developing areas but attributed more to respiratory droplet in developed areas. Transmission is facilitated by the prolonged environmental survival of these viruses and their greater resistance to biocides. Serious outbreaks with neurological and cardiopulmonary complications caused by human enterovirus 71 (HEV-71) seem to be commoner in the Asian Pacific region than elsewhere in the world. This geographical predilection is unexplained but could be related to the frequency of intra- and inter-typic genetic recombinations of the virus, the host populations' genetic predisposition, environmental hygiene, and standard of healthcare. Vaccine development could be hampered by the general mildness of the illness and rapid genetic evolution of the virus. Antivirals are not readily available; the role of intravenous immunoglobulin in the treatment of serious complications should be investigated. Monitoring of this disease and its epidemiology in the densely populated Asia Pacific epicentre is important for the detection of emerging epidemics due to enteroviruses. Copyright © 2010 Cambridge University Press.
ISSN0950-2688
2011 Impact Factor: 2.843
2011 SCImago Journal Rankings: 0.228
DOIhttp://dx.doi.org/10.1017/S0950268809991555
ISI Accession Number IDWOS:000280136700001
Funding AgencyGrant Number
University of Hong Kong
Ms Teresa On-Yik Wong
Providence Foundation Limited
Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

The authors acknowledge funding from the University Development Fund 2001-2002 (first round) of The University of Hong Kong, Clinical Infectious Diseases Research Endowment Fund from Ms Teresa On-Yik Wong, Providence Foundation Limited in memory of the late Dr Lui Hac Minh, Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau of the Hong Kong SAR Government.

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWong, SSY
dc.contributor.authorYip, CCY
dc.contributor.authorLau, SKP
dc.contributor.authorYuen, KY
dc.date.accessioned2010-10-31T11:12:41Z
dc.date.available2010-10-31T11:12:41Z
dc.date.issued2010
dc.description.abstractHand, foot and mouth disease (HFMD) is generally a benign febrile exanthematous childhood disease caused by human enteroviruses. The route of transmission is postulated to be faeco-oral in developing areas but attributed more to respiratory droplet in developed areas. Transmission is facilitated by the prolonged environmental survival of these viruses and their greater resistance to biocides. Serious outbreaks with neurological and cardiopulmonary complications caused by human enterovirus 71 (HEV-71) seem to be commoner in the Asian Pacific region than elsewhere in the world. This geographical predilection is unexplained but could be related to the frequency of intra- and inter-typic genetic recombinations of the virus, the host populations' genetic predisposition, environmental hygiene, and standard of healthcare. Vaccine development could be hampered by the general mildness of the illness and rapid genetic evolution of the virus. Antivirals are not readily available; the role of intravenous immunoglobulin in the treatment of serious complications should be investigated. Monitoring of this disease and its epidemiology in the densely populated Asia Pacific epicentre is important for the detection of emerging epidemics due to enteroviruses. Copyright © 2010 Cambridge University Press.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationEpidemiology And Infection, 2010, v. 138 n. 8, p. 1071-1089 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0950268809991555
dc.identifier.doihttp://dx.doi.org/10.1017/S0950268809991555
dc.identifier.epage1089
dc.identifier.hkuros179553
dc.identifier.isiWOS:000280136700001
Funding AgencyGrant Number
University of Hong Kong
Ms Teresa On-Yik Wong
Providence Foundation Limited
Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

The authors acknowledge funding from the University Development Fund 2001-2002 (first round) of The University of Hong Kong, Clinical Infectious Diseases Research Endowment Fund from Ms Teresa On-Yik Wong, Providence Foundation Limited in memory of the late Dr Lui Hac Minh, Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau of the Hong Kong SAR Government.

dc.identifier.issn0950-2688
2011 Impact Factor: 2.843
2011 SCImago Journal Rankings: 0.228
dc.identifier.issue8
dc.identifier.openurl
dc.identifier.scopuseid_2-s2.0-77954931134
dc.identifier.spage1071
dc.identifier.urihttp://hdl.handle.net/10722/125123
dc.identifier.volume138
dc.languageeng
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
dc.publisher.placeUnited Kingdom
dc.relation.ispartofEpidemiology and Infection
dc.relation.referencesReferences in Scopus
dc.subjectenterovirus
dc.subjectenterovirus 71
dc.subjectfoot and mouth disease
dc.subjectHand
dc.titleHuman enterovirus 71 and hand, foot and mouth disease
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong