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Article: Human enterovirus 71 and hand, foot and mouth disease
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TitleHuman enterovirus 71 and hand, foot and mouth disease
 
AuthorsWong, SSY1
Yip, CCY1
Lau, SKP1
Yuen, KY1
 
Keywordsenterovirus
enterovirus 71
foot and mouth disease
Hand
 
Issue Date2010
 
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
 
CitationEpidemiology And Infection, 2010, v. 138 n. 8, p. 1071-1089 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0950268809991555
 
AbstractHand, foot and mouth disease (HFMD) is generally a benign febrile exanthematous childhood disease caused by human enteroviruses. The route of transmission is postulated to be faeco-oral in developing areas but attributed more to respiratory droplet in developed areas. Transmission is facilitated by the prolonged environmental survival of these viruses and their greater resistance to biocides. Serious outbreaks with neurological and cardiopulmonary complications caused by human enterovirus 71 (HEV-71) seem to be commoner in the Asian Pacific region than elsewhere in the world. This geographical predilection is unexplained but could be related to the frequency of intra- and inter-typic genetic recombinations of the virus, the host populations' genetic predisposition, environmental hygiene, and standard of healthcare. Vaccine development could be hampered by the general mildness of the illness and rapid genetic evolution of the virus. Antivirals are not readily available; the role of intravenous immunoglobulin in the treatment of serious complications should be investigated. Monitoring of this disease and its epidemiology in the densely populated Asia Pacific epicentre is important for the detection of emerging epidemics due to enteroviruses. Copyright © 2010 Cambridge University Press.
 
ISSN0950-2688
2013 Impact Factor: 2.491
 
DOIhttp://dx.doi.org/10.1017/S0950268809991555
 
ISI Accession Number IDWOS:000280136700001
Funding AgencyGrant Number
University of Hong Kong
Ms Teresa On-Yik Wong
Providence Foundation Limited
Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

The authors acknowledge funding from the University Development Fund 2001-2002 (first round) of The University of Hong Kong, Clinical Infectious Diseases Research Endowment Fund from Ms Teresa On-Yik Wong, Providence Foundation Limited in memory of the late Dr Lui Hac Minh, Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau of the Hong Kong SAR Government.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, SSY
 
dc.contributor.authorYip, CCY
 
dc.contributor.authorLau, SKP
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2010-10-31T11:12:41Z
 
dc.date.available2010-10-31T11:12:41Z
 
dc.date.issued2010
 
dc.description.abstractHand, foot and mouth disease (HFMD) is generally a benign febrile exanthematous childhood disease caused by human enteroviruses. The route of transmission is postulated to be faeco-oral in developing areas but attributed more to respiratory droplet in developed areas. Transmission is facilitated by the prolonged environmental survival of these viruses and their greater resistance to biocides. Serious outbreaks with neurological and cardiopulmonary complications caused by human enterovirus 71 (HEV-71) seem to be commoner in the Asian Pacific region than elsewhere in the world. This geographical predilection is unexplained but could be related to the frequency of intra- and inter-typic genetic recombinations of the virus, the host populations' genetic predisposition, environmental hygiene, and standard of healthcare. Vaccine development could be hampered by the general mildness of the illness and rapid genetic evolution of the virus. Antivirals are not readily available; the role of intravenous immunoglobulin in the treatment of serious complications should be investigated. Monitoring of this disease and its epidemiology in the densely populated Asia Pacific epicentre is important for the detection of emerging epidemics due to enteroviruses. Copyright © 2010 Cambridge University Press.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationEpidemiology And Infection, 2010, v. 138 n. 8, p. 1071-1089 [How to Cite?]
DOI: http://dx.doi.org/10.1017/S0950268809991555
 
dc.identifier.doihttp://dx.doi.org/10.1017/S0950268809991555
 
dc.identifier.epage1089
 
dc.identifier.hkuros179553
 
dc.identifier.isiWOS:000280136700001
Funding AgencyGrant Number
University of Hong Kong
Ms Teresa On-Yik Wong
Providence Foundation Limited
Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

The authors acknowledge funding from the University Development Fund 2001-2002 (first round) of The University of Hong Kong, Clinical Infectious Diseases Research Endowment Fund from Ms Teresa On-Yik Wong, Providence Foundation Limited in memory of the late Dr Lui Hac Minh, Research Fund for the Control of Infectious Diseases (RFCID) of the Food and Health Bureau of the Hong Kong SAR Government.

 
dc.identifier.issn0950-2688
2013 Impact Factor: 2.491
 
dc.identifier.issue8
 
dc.identifier.openurl
 
dc.identifier.scopuseid_2-s2.0-77954931134
 
dc.identifier.spage1071
 
dc.identifier.urihttp://hdl.handle.net/10722/125123
 
dc.identifier.volume138
 
dc.languageeng
 
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofEpidemiology and Infection
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectenterovirus
 
dc.subjectenterovirus 71
 
dc.subjectfoot and mouth disease
 
dc.subjectHand
 
dc.titleHuman enterovirus 71 and hand, foot and mouth disease
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong