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Article: Current antibody-based immunoassay algorithm failed to confirm three late-stage AIDS cases in China: Case report

TitleCurrent antibody-based immunoassay algorithm failed to confirm three late-stage AIDS cases in China: Case report
Authors
Issue Date2010
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.virologyj.com/home/
Citation
Virology Journal, 2010, p. 58 How to Cite?
AbstractBackground: Immunoassays composed of screening and confirmation are the established algorithm to confirm HIV infection in China, with a Western blot result as the final diagnosis. Case Presentation: In this report, three late-stage AIDS patients were initially tested HIV antibody positive using multiple screening kits, but tested indeterminate using Western blot. HIV infection diagnosis was confirmed based on nucleic acid assays, clinic manifestations and epidemiological history. Case A was identified positive at 30 months, using Western blot, Case B at 8 months, and case C remained indeterminate until he died of Kaposi's sarcoma 4 months after HAART. Conclusion: The report indicates that current antibody-based testing algorithms may miss late-stage AIDS patients and therefore miss the opportunity for preventing these cases from further transmission. The report also implies that viral load assays is not easy to be universely applicated in developing country like China although it is helpful in diagnosing complicated cases of HIV infection, so the counselling before and after testing is imperative to the diagnosis of HIV infection and risk behavior survey on the eaxminee should be as detailed as possible.
Persistent Identifierhttp://hdl.handle.net/10722/125118
ISSN
2015 Impact Factor: 2.362
2015 SCImago Journal Rankings: 1.166
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Health Bureau of Guangzhou2007-ZDi-08
Science & Technology Bureau of Guangzhou2006ZI-E0091
Funding Information:

This work was performed with funds from Health Bureau of Guangzhou (2007-ZDi-08) and Science & Technology Bureau of Guangzhou (2006ZI-E0091). We are very grateful to the three cases for their long-term cooperation. We also want to thank staff of Section of AIDS Control and Prevention, Guangzhou Center for Disease Control and Prevention, for their excellent work on this study.

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_HK
dc.contributor.authorZhao, JKen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorHan, ZGen_HK
dc.contributor.authorCai, WPen_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorXu, HFen_HK
dc.date.accessioned2010-10-31T11:12:24Z-
dc.date.available2010-10-31T11:12:24Z-
dc.date.issued2010en_HK
dc.identifier.citationVirology Journal, 2010, p. 58en_HK
dc.identifier.issn1743-422Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/125118-
dc.description.abstractBackground: Immunoassays composed of screening and confirmation are the established algorithm to confirm HIV infection in China, with a Western blot result as the final diagnosis. Case Presentation: In this report, three late-stage AIDS patients were initially tested HIV antibody positive using multiple screening kits, but tested indeterminate using Western blot. HIV infection diagnosis was confirmed based on nucleic acid assays, clinic manifestations and epidemiological history. Case A was identified positive at 30 months, using Western blot, Case B at 8 months, and case C remained indeterminate until he died of Kaposi's sarcoma 4 months after HAART. Conclusion: The report indicates that current antibody-based testing algorithms may miss late-stage AIDS patients and therefore miss the opportunity for preventing these cases from further transmission. The report also implies that viral load assays is not easy to be universely applicated in developing country like China although it is helpful in diagnosing complicated cases of HIV infection, so the counselling before and after testing is imperative to the diagnosis of HIV infection and risk behavior survey on the eaxminee should be as detailed as possible.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.virologyj.com/home/en_HK
dc.relation.ispartofVirology Journalen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsVirology Journal. Copyright © BioMed Central Ltd.-
dc.subject.meshAcquired Immunodeficiency Syndrome - diagnosis-
dc.subject.meshAlgorithms-
dc.subject.meshDiagnostic Errors-
dc.subject.meshHIV Antibodies - blood-
dc.subject.meshImmunoassay - methods-
dc.titleCurrent antibody-based immunoassay algorithm failed to confirm three late-stage AIDS cases in China: Case reporten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1743-422X&volume=7 article no. 58&spage=&epage=&date=2010&atitle=Current+antibody-based+immunoassay+algorithm+failed+to+confirm+three+late-stage+AIDS+cases+in+China:+case+report-
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1743-422X-7-58en_HK
dc.identifier.pmid20230617-
dc.identifier.pmcidPMC2850901-
dc.identifier.scopuseid_2-s2.0-77949452558en_HK
dc.identifier.hkuros175101en_HK
dc.identifier.volume7 article no. 58-
dc.identifier.spage58en_HK
dc.identifier.epage58en_HK
dc.identifier.isiWOS:000276436100001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, Y=36078298200en_HK
dc.identifier.scopusauthoridZhao, JK=8623504200en_HK
dc.identifier.scopusauthoridWang, M=7406685232en_HK
dc.identifier.scopusauthoridHan, ZG=35101970800en_HK
dc.identifier.scopusauthoridCai, WP=55187837500en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridXu, HF=7407448207en_HK
dc.identifier.citeulike6870636-

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