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Article: HCN-encoded pacemaker channels: From physiology and biophysics to bioengineering

TitleHCN-encoded pacemaker channels: From physiology and biophysics to bioengineering
Authors
KeywordsBioengineering
Gene transfer
HCN channel
Physiology
Stem cells
Issue Date2006
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00232/
Citation
Journal Of Membrane Biology, 2006, v. 214 n. 3, p. 115-122 How to Cite?
AbstractThe depolarizing membrane ionic current I h (also known as I f, "f" for funny), encoded by the hyperpolarization- activated cyclic-nucleotide-modulated (HCN1-4) channel gene family, was first discovered in the heart over 25 years ago. Later, I h was also found in neurons, retina, and taste buds. HCN channels structurally resemble voltage-gated K+ (Kv) channels but the molecular features underlying their opposite gating behaviors (activation by hyperpolarization rather than depolarization) and non-selective permeation profiles (≥25 times less selective for K+ than Kv channels) remain largely unknown. Although I h has been functionally linked to biological processes from the autonomous beating of the heart to pain transmission, the underlying mechanistic actions remain largely inferential and, indeed, somewhat controversial due to the slow kinetics and negative operating voltage range relative to those of the bioelectrical events involved (e.g., cardiac pacing). This article reviews the current state of our knowledge in the structure-function properties of HCN channels in the context of their physiological functions and potential HCN-based therapies via bioengineering. © 2007 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/125105
ISSN
2015 Impact Factor: 1.991
2015 SCImago Journal Rankings: 0.738
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorLieu, DKen_HK
dc.contributor.authorLi, RAen_HK
dc.date.accessioned2010-10-31T11:11:37Z-
dc.date.available2010-10-31T11:11:37Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Membrane Biology, 2006, v. 214 n. 3, p. 115-122en_HK
dc.identifier.issn0022-2631en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125105-
dc.description.abstractThe depolarizing membrane ionic current I h (also known as I f, "f" for funny), encoded by the hyperpolarization- activated cyclic-nucleotide-modulated (HCN1-4) channel gene family, was first discovered in the heart over 25 years ago. Later, I h was also found in neurons, retina, and taste buds. HCN channels structurally resemble voltage-gated K+ (Kv) channels but the molecular features underlying their opposite gating behaviors (activation by hyperpolarization rather than depolarization) and non-selective permeation profiles (≥25 times less selective for K+ than Kv channels) remain largely unknown. Although I h has been functionally linked to biological processes from the autonomous beating of the heart to pain transmission, the underlying mechanistic actions remain largely inferential and, indeed, somewhat controversial due to the slow kinetics and negative operating voltage range relative to those of the bioelectrical events involved (e.g., cardiac pacing). This article reviews the current state of our knowledge in the structure-function properties of HCN channels in the context of their physiological functions and potential HCN-based therapies via bioengineering. © 2007 Springer Science+Business Media, LLC.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00232/en_HK
dc.relation.ispartofJournal of Membrane Biologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectBioengineeringen_HK
dc.subjectGene transferen_HK
dc.subjectHCN channelen_HK
dc.subjectPhysiologyen_HK
dc.subjectStem cellsen_HK
dc.subject.meshHeart Conduction System - physiology-
dc.subject.meshIon Channel Gating - physiology-
dc.subject.meshMembrane Potentials - physiology-
dc.subject.meshMyocardium - metabolism-
dc.subject.meshPotassium Channels - genetics - metabolism-
dc.titleHCN-encoded pacemaker channels: From physiology and biophysics to bioengineeringen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2631&volume=214&issue=3&spage=115&epage=122&date=2006&atitle=HCN-encoded+Pacemaker+Channels:+From+Physiology,+Biophysics+to+Bioengineering-
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailLi, RA:ronaldli@hkucc.hku.hken_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityLi, RA=rp01352en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00232-006-0881-9en_HK
dc.identifier.pmid17558529-
dc.identifier.scopuseid_2-s2.0-34447306926en_HK
dc.identifier.hkuros183048en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447306926&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume214en_HK
dc.identifier.issue3en_HK
dc.identifier.spage115en_HK
dc.identifier.epage122en_HK
dc.identifier.isiWOS:000247991600001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridLieu, DK=7003924538en_HK
dc.identifier.scopusauthoridLi, RA=7404724466en_HK
dc.identifier.citeulike1613241-

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