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Article: Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of life.
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TitleSevere oral mucositis associated with cancer therapy: impact on oral functional status and quality of life.
 
AuthorsCheng, KK
Leung, SF2
Liang, RH1
Tai, JW
Yeung, RM
Thompson, DR5
 
KeywordsPain
Quality of life
Severe oral mucositis
Symptoms
 
Issue Date2010
 
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00520/index.htm
 
CitationSupportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2010, v. 18 n. 11, p. 1477-1485 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00520-009-0771-7
 
AbstractThis study determined the incidence of severe oral mucositis (OM), patients' self-reported moderate and severe oral symptoms, and change of quality of life (QoL), as well as examined whether OM severity and pain scores predicted the impairment of oral function and QoL. A multicenter approach was used and 137 patients treated with stomatotoxic chemotherapy (45%), high-dose myeloablative chemotherapy with or without concomitant total body irradiation (12%), head and neck irradiation with or without concomitant chemotherapy (44%) completed the OM-specific QoL measure (OMQoL) once or twice weekly over a 4- or 10-week period, along with concurrent measures of OM using WHO Mucositis Grading System and oral symptoms using 10 cm visual analog scale. The incidence of severe OM was 50% (n = 68). About 77-80% of patients with severe OM reported moderate or severe mouth or throat pain, and 66-78% reported moderate or severe oral functional problems. The oral symptoms peak and area-under-the-curve (AUC) scores of patients with severe OM (peak 5.6 to 6.8; AUC 3.8 to 5.2) were significantly higher than those without OM and those with mild OM (p < 0.01). The OMQoL subscales peak and AUC scores of patients with severe OM (peak 47.9 to 62.1; AUC -40.1 to -25.8) were significantly lower than those without OM and those with mild OM (p < 0.01). Of those with severe OM, 88-94% had a drop in the OMQoL subscale scores to at least 10 points from the baseline. Pain resulting from OM, in particular throat pain, is most predictive of oral functional impairment (standardized β = 0.53-0.83). Severe OM can cause profound pain and oral functional incapability and clinical significant impairment of QoL.
 
ISSN1433-7339
2013 SCImago Journal Rankings: 1.190
 
DOIhttp://dx.doi.org/10.1007/s00520-009-0771-7
 
ISI Accession Number IDWOS:000282182500015
Funding AgencyGrant Number
Health, Welfare and Food Bureau of Hong Kong
Funding Information:

This study was supported by the Health and Health Services Research Fund of the Health, Welfare and Food Bureau of Hong Kong.

 
DC FieldValue
dc.contributor.authorCheng, KK
 
dc.contributor.authorLeung, SF
 
dc.contributor.authorLiang, RH
 
dc.contributor.authorTai, JW
 
dc.contributor.authorYeung, RM
 
dc.contributor.authorThompson, DR
 
dc.date.accessioned2010-10-31T11:11:24Z
 
dc.date.available2010-10-31T11:11:24Z
 
dc.date.issued2010
 
dc.description.abstractThis study determined the incidence of severe oral mucositis (OM), patients' self-reported moderate and severe oral symptoms, and change of quality of life (QoL), as well as examined whether OM severity and pain scores predicted the impairment of oral function and QoL. A multicenter approach was used and 137 patients treated with stomatotoxic chemotherapy (45%), high-dose myeloablative chemotherapy with or without concomitant total body irradiation (12%), head and neck irradiation with or without concomitant chemotherapy (44%) completed the OM-specific QoL measure (OMQoL) once or twice weekly over a 4- or 10-week period, along with concurrent measures of OM using WHO Mucositis Grading System and oral symptoms using 10 cm visual analog scale. The incidence of severe OM was 50% (n = 68). About 77-80% of patients with severe OM reported moderate or severe mouth or throat pain, and 66-78% reported moderate or severe oral functional problems. The oral symptoms peak and area-under-the-curve (AUC) scores of patients with severe OM (peak 5.6 to 6.8; AUC 3.8 to 5.2) were significantly higher than those without OM and those with mild OM (p < 0.01). The OMQoL subscales peak and AUC scores of patients with severe OM (peak 47.9 to 62.1; AUC -40.1 to -25.8) were significantly lower than those without OM and those with mild OM (p < 0.01). Of those with severe OM, 88-94% had a drop in the OMQoL subscale scores to at least 10 points from the baseline. Pain resulting from OM, in particular throat pain, is most predictive of oral functional impairment (standardized β = 0.53-0.83). Severe OM can cause profound pain and oral functional incapability and clinical significant impairment of QoL.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationSupportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2010, v. 18 n. 11, p. 1477-1485 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00520-009-0771-7
 
dc.identifier.citeulike6212685
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00520-009-0771-7
 
dc.identifier.epage1485
 
dc.identifier.hkuros180743
 
dc.identifier.isiWOS:000282182500015
Funding AgencyGrant Number
Health, Welfare and Food Bureau of Hong Kong
Funding Information:

This study was supported by the Health and Health Services Research Fund of the Health, Welfare and Food Bureau of Hong Kong.

 
dc.identifier.issn1433-7339
2013 SCImago Journal Rankings: 1.190
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmid19916030
 
dc.identifier.scopuseid_2-s2.0-79952116338
 
dc.identifier.spage1477
 
dc.identifier.urihttp://hdl.handle.net/10722/125101
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00520/index.htm
 
dc.relation.ispartofSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
 
dc.rightsThe original publication is available at www.springerlink.com
 
dc.subject.meshAntineoplastic Agents - adverse effects
 
dc.subject.meshCombined Modality Therapy - adverse effects
 
dc.subject.meshNeoplasms - therapy
 
dc.subject.meshQuality of Life
 
dc.subject.meshStomatitis - epidemiology - etiology - physiopathology
 
dc.subjectPain
 
dc.subjectQuality of life
 
dc.subjectSevere oral mucositis
 
dc.subjectSymptoms
 
dc.titleSevere oral mucositis associated with cancer therapy: impact on oral functional status and quality of life.
 
dc.typeArticle
 
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<contributor.author>Liang, RH</contributor.author>
<contributor.author>Tai, JW</contributor.author>
<contributor.author>Yeung, RM</contributor.author>
<contributor.author>Thompson, DR</contributor.author>
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<description.abstract>This study determined the incidence of severe oral mucositis (OM), patients&apos; self-reported moderate and severe oral symptoms, and change of quality of life (QoL), as well as examined whether OM severity and pain scores predicted the impairment of oral function and QoL. A multicenter approach was used and 137 patients treated with stomatotoxic chemotherapy (45%), high-dose myeloablative chemotherapy with or without concomitant total body irradiation (12%), head and neck irradiation with or without concomitant chemotherapy (44%) completed the OM-specific QoL measure (OMQoL) once or twice weekly over a 4- or 10-week period, along with concurrent measures of OM using WHO Mucositis Grading System and oral symptoms using 10 cm visual analog scale. The incidence of severe OM was 50% (n = 68). About 77-80% of patients with severe OM reported moderate or severe mouth or throat pain, and 66-78% reported moderate or severe oral functional problems. The oral symptoms peak and area-under-the-curve (AUC) scores of patients with severe OM (peak 5.6 to 6.8; AUC 3.8 to 5.2) were significantly higher than those without OM and those with mild OM (p &lt; 0.01). The OMQoL subscales peak and AUC scores of patients with severe OM (peak 47.9 to 62.1; AUC -40.1 to -25.8) were significantly lower than those without OM and those with mild OM (p &lt; 0.01). Of those with severe OM, 88-94% had a drop in the OMQoL subscale scores to at least 10 points from the baseline. Pain resulting from OM, in particular throat pain, is most predictive of oral functional impairment (standardized &#946; = 0.53-0.83). Severe OM can cause profound pain and oral functional incapability and clinical significant impairment of QoL.</description.abstract>
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<subject>Pain</subject>
<subject>Quality of life</subject>
<subject>Severe oral mucositis</subject>
<subject>Symptoms</subject>
<subject.mesh>Antineoplastic Agents - adverse effects</subject.mesh>
<subject.mesh>Combined Modality Therapy - adverse effects</subject.mesh>
<subject.mesh>Neoplasms - therapy</subject.mesh>
<subject.mesh>Quality of Life</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong
  2. Prince of Wales Hospital Hong Kong
  3. Pamela Youde Nethersole Eastern Hospital
  4. Queen Mary Hospital Hong Kong
  5. University of Leicester
  6. Chinese University of Hong Kong