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Article: Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of life.

TitleSevere oral mucositis associated with cancer therapy: impact on oral functional status and quality of life.
Authors
KeywordsPain
Quality of life
Severe oral mucositis
Symptoms
Issue Date2010
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00520/index.htm
Citation
Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2010, v. 18 n. 11, p. 1477-1485 How to Cite?
AbstractThis study determined the incidence of severe oral mucositis (OM), patients' self-reported moderate and severe oral symptoms, and change of quality of life (QoL), as well as examined whether OM severity and pain scores predicted the impairment of oral function and QoL. A multicenter approach was used and 137 patients treated with stomatotoxic chemotherapy (45%), high-dose myeloablative chemotherapy with or without concomitant total body irradiation (12%), head and neck irradiation with or without concomitant chemotherapy (44%) completed the OM-specific QoL measure (OMQoL) once or twice weekly over a 4- or 10-week period, along with concurrent measures of OM using WHO Mucositis Grading System and oral symptoms using 10 cm visual analog scale. The incidence of severe OM was 50% (n = 68). About 77-80% of patients with severe OM reported moderate or severe mouth or throat pain, and 66-78% reported moderate or severe oral functional problems. The oral symptoms peak and area-under-the-curve (AUC) scores of patients with severe OM (peak 5.6 to 6.8; AUC 3.8 to 5.2) were significantly higher than those without OM and those with mild OM (p < 0.01). The OMQoL subscales peak and AUC scores of patients with severe OM (peak 47.9 to 62.1; AUC -40.1 to -25.8) were significantly lower than those without OM and those with mild OM (p < 0.01). Of those with severe OM, 88-94% had a drop in the OMQoL subscale scores to at least 10 points from the baseline. Pain resulting from OM, in particular throat pain, is most predictive of oral functional impairment (standardized β = 0.53-0.83). Severe OM can cause profound pain and oral functional incapability and clinical significant impairment of QoL.
Persistent Identifierhttp://hdl.handle.net/10722/125101
ISSN
2015 SCImago Journal Rankings: 1.267
ISI Accession Number ID
Funding AgencyGrant Number
Health, Welfare and Food Bureau of Hong Kong
Funding Information:

This study was supported by the Health and Health Services Research Fund of the Health, Welfare and Food Bureau of Hong Kong.

 

DC FieldValueLanguage
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorLeung, SFen_HK
dc.contributor.authorLiang, RHen_HK
dc.contributor.authorTai, JWen_HK
dc.contributor.authorYeung, RMen_HK
dc.contributor.authorThompson, DRen_HK
dc.date.accessioned2010-10-31T11:11:24Z-
dc.date.available2010-10-31T11:11:24Z-
dc.date.issued2010en_HK
dc.identifier.citationSupportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2010, v. 18 n. 11, p. 1477-1485en_HK
dc.identifier.issn1433-7339en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125101-
dc.description.abstractThis study determined the incidence of severe oral mucositis (OM), patients' self-reported moderate and severe oral symptoms, and change of quality of life (QoL), as well as examined whether OM severity and pain scores predicted the impairment of oral function and QoL. A multicenter approach was used and 137 patients treated with stomatotoxic chemotherapy (45%), high-dose myeloablative chemotherapy with or without concomitant total body irradiation (12%), head and neck irradiation with or without concomitant chemotherapy (44%) completed the OM-specific QoL measure (OMQoL) once or twice weekly over a 4- or 10-week period, along with concurrent measures of OM using WHO Mucositis Grading System and oral symptoms using 10 cm visual analog scale. The incidence of severe OM was 50% (n = 68). About 77-80% of patients with severe OM reported moderate or severe mouth or throat pain, and 66-78% reported moderate or severe oral functional problems. The oral symptoms peak and area-under-the-curve (AUC) scores of patients with severe OM (peak 5.6 to 6.8; AUC 3.8 to 5.2) were significantly higher than those without OM and those with mild OM (p < 0.01). The OMQoL subscales peak and AUC scores of patients with severe OM (peak 47.9 to 62.1; AUC -40.1 to -25.8) were significantly lower than those without OM and those with mild OM (p < 0.01). Of those with severe OM, 88-94% had a drop in the OMQoL subscale scores to at least 10 points from the baseline. Pain resulting from OM, in particular throat pain, is most predictive of oral functional impairment (standardized β = 0.53-0.83). Severe OM can cause profound pain and oral functional incapability and clinical significant impairment of QoL.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00520/index.htm-
dc.relation.ispartofSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Canceren_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectPainen_HK
dc.subjectQuality of lifeen_HK
dc.subjectSevere oral mucositisen_HK
dc.subjectSymptomsen_HK
dc.subject.meshAntineoplastic Agents - adverse effects-
dc.subject.meshCombined Modality Therapy - adverse effects-
dc.subject.meshNeoplasms - therapy-
dc.subject.meshQuality of Life-
dc.subject.meshStomatitis - epidemiology - etiology - physiopathology-
dc.titleSevere oral mucositis associated with cancer therapy: impact on oral functional status and quality of life.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0941-4355&volume=18&issue=11&spage=1477&epage=1485&date=2010&atitle=Severe+oral+mucositis+associated+with+cancer+therapy:+impact+on+oral+functional+status+and+quality+of+life-
dc.identifier.emailLiang, RH:rliang@hku.hken_HK
dc.identifier.authorityLiang, RH=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00520-009-0771-7en_HK
dc.identifier.pmid19916030en_HK
dc.identifier.scopuseid_2-s2.0-79952116338en_HK
dc.identifier.hkuros180743en_HK
dc.identifier.volume18en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1477en_HK
dc.identifier.epage1485en_HK
dc.identifier.isiWOS:000282182500015-
dc.identifier.scopusauthoridCheng, KK=27168596400en_HK
dc.identifier.scopusauthoridLeung, SF=7202044876en_HK
dc.identifier.scopusauthoridLiang, RH=26643224900en_HK
dc.identifier.scopusauthoridTai, JW=7101993154en_HK
dc.identifier.scopusauthoridYeung, RM=7102833329en_HK
dc.identifier.scopusauthoridThompson, DR=7404935331en_HK
dc.identifier.citeulike6212685-

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