Article: Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of life.
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- Publisher Website: 10.1007/s00520-009-0771-7
- Scopus: eid_2-s2.0-79952116338
- PMID: 19916030
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| Title | Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of life. | ||||
|---|---|---|---|---|---|
| Authors | Cheng, KK Leung, SF2 Liang, RH1 Tai, JW Yeung, RM Thompson, DR5 | ||||
| Keywords | Pain Quality of life Severe oral mucositis Symptoms | ||||
| Issue Date | 2010 | ||||
| Publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00520/index.htm | ||||
| Citation | Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2010, v. 18 n. 11, p. 1477-1485 [How to Cite?] DOI: http://dx.doi.org/10.1007/s00520-009-0771-7 | ||||
| Abstract | This study determined the incidence of severe oral mucositis (OM), patients' self-reported moderate and severe oral symptoms, and change of quality of life (QoL), as well as examined whether OM severity and pain scores predicted the impairment of oral function and QoL. A multicenter approach was used and 137 patients treated with stomatotoxic chemotherapy (45%), high-dose myeloablative chemotherapy with or without concomitant total body irradiation (12%), head and neck irradiation with or without concomitant chemotherapy (44%) completed the OM-specific QoL measure (OMQoL) once or twice weekly over a 4- or 10-week period, along with concurrent measures of OM using WHO Mucositis Grading System and oral symptoms using 10 cm visual analog scale. The incidence of severe OM was 50% (n = 68). About 77-80% of patients with severe OM reported moderate or severe mouth or throat pain, and 66-78% reported moderate or severe oral functional problems. The oral symptoms peak and area-under-the-curve (AUC) scores of patients with severe OM (peak 5.6 to 6.8; AUC 3.8 to 5.2) were significantly higher than those without OM and those with mild OM (p < 0.01). The OMQoL subscales peak and AUC scores of patients with severe OM (peak 47.9 to 62.1; AUC -40.1 to -25.8) were significantly lower than those without OM and those with mild OM (p < 0.01). Of those with severe OM, 88-94% had a drop in the OMQoL subscale scores to at least 10 points from the baseline. Pain resulting from OM, in particular throat pain, is most predictive of oral functional impairment (standardized β = 0.53-0.83). Severe OM can cause profound pain and oral functional incapability and clinical significant impairment of QoL. | ||||
| ISSN | 1433-7339 2011 SCImago Journal Rankings: 0.203 | ||||
| DOI | http://dx.doi.org/10.1007/s00520-009-0771-7 | ||||
| ISI Accession Number ID | WOS:000282182500015
Funding Information: This study was supported by the Health and Health Services Research Fund of the Health, Welfare and Food Bureau of Hong Kong. |
| dc.contributor.author | Cheng, KK | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Leung, SF | ||||
| dc.contributor.author | Liang, RH | ||||
| dc.contributor.author | Tai, JW | ||||
| dc.contributor.author | Yeung, RM | ||||
| dc.contributor.author | Thompson, DR | ||||
| dc.date.accessioned | 2010-10-31T11:11:24Z | ||||
| dc.date.available | 2010-10-31T11:11:24Z | ||||
| dc.date.issued | 2010 | ||||
| dc.description.abstract | This study determined the incidence of severe oral mucositis (OM), patients' self-reported moderate and severe oral symptoms, and change of quality of life (QoL), as well as examined whether OM severity and pain scores predicted the impairment of oral function and QoL. A multicenter approach was used and 137 patients treated with stomatotoxic chemotherapy (45%), high-dose myeloablative chemotherapy with or without concomitant total body irradiation (12%), head and neck irradiation with or without concomitant chemotherapy (44%) completed the OM-specific QoL measure (OMQoL) once or twice weekly over a 4- or 10-week period, along with concurrent measures of OM using WHO Mucositis Grading System and oral symptoms using 10 cm visual analog scale. The incidence of severe OM was 50% (n = 68). About 77-80% of patients with severe OM reported moderate or severe mouth or throat pain, and 66-78% reported moderate or severe oral functional problems. The oral symptoms peak and area-under-the-curve (AUC) scores of patients with severe OM (peak 5.6 to 6.8; AUC 3.8 to 5.2) were significantly higher than those without OM and those with mild OM (p < 0.01). The OMQoL subscales peak and AUC scores of patients with severe OM (peak 47.9 to 62.1; AUC -40.1 to -25.8) were significantly lower than those without OM and those with mild OM (p < 0.01). Of those with severe OM, 88-94% had a drop in the OMQoL subscale scores to at least 10 points from the baseline. Pain resulting from OM, in particular throat pain, is most predictive of oral functional impairment (standardized β = 0.53-0.83). Severe OM can cause profound pain and oral functional incapability and clinical significant impairment of QoL. | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Supportive Care In Cancer : Official Journal Of The Multinational Association Of Supportive Care In Cancer, 2010, v. 18 n. 11, p. 1477-1485 [How to Cite?] DOI: http://dx.doi.org/10.1007/s00520-009-0771-7 | ||||
| dc.identifier.citeulike | 6212685 | ||||
| dc.identifier.doi | http://dx.doi.org/10.1007/s00520-009-0771-7 | ||||
| dc.identifier.epage | 1485 | ||||
| dc.identifier.hkuros | 180743 | ||||
| dc.identifier.isi | WOS:000282182500015
Funding Information: This study was supported by the Health and Health Services Research Fund of the Health, Welfare and Food Bureau of Hong Kong. | ||||
| dc.identifier.issn | 1433-7339 2011 SCImago Journal Rankings: 0.203 | ||||
| dc.identifier.issue | 11 | ||||
| dc.identifier.openurl | | ||||
| dc.identifier.pmid | 19916030 | ||||
| dc.identifier.scopus | eid_2-s2.0-79952116338 | ||||
| dc.identifier.spage | 1477 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/125101 | ||||
| dc.identifier.volume | 18 | ||||
| dc.language | eng | ||||
| dc.publisher | Springer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00520/index.htm | ||||
| dc.relation.ispartof | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer | ||||
| dc.rights | The original publication is available at www.springerlink.com | ||||
| dc.subject.mesh | Antineoplastic Agents - adverse effects | ||||
| dc.subject.mesh | Combined Modality Therapy - adverse effects | ||||
| dc.subject.mesh | Neoplasms - therapy | ||||
| dc.subject.mesh | Quality of Life | ||||
| dc.subject.mesh | Stomatitis - epidemiology - etiology - physiopathology | ||||
| dc.subject | Pain | ||||
| dc.subject | Quality of life | ||||
| dc.subject | Severe oral mucositis | ||||
| dc.subject | Symptoms | ||||
| dc.title | Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of life. | ||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- Prince of Wales Hospital Hong Kong
- Pamela Youde Nethersole Eastern Hospital
- Queen Mary Hospital Hong Kong
- University of Leicester
- Chinese University of Hong Kong