File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease

TitleImprovement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
Authors
Issue Date2010
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.jcmr-online.com/home
Citation
Journal Of Cardiovascular Magnetic Resonance, 2010, v. 12 n. 1 How to Cite?
AbstractBackground. Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR). Methods and Results. We compared the interval changes of left ventricular ejection fraction (LVEF), myocardial perfusion reserve and the extent of myocardial scar by using late gadolinium enhancement CMR in 12 patients with severe CAD. CMR was performed at baseline and at 6 months after catheter-based direct endomyocardial autologous BM cell (n = 12) injection to viable ischaemic myocardium as guided by electromechanical mapping. In patients randomized to receive BM cell injection, there was significant decrease in percentage area of peri-infarct regions (-23.6%, P = 0.04) and increase in global LVEF (+9.0%, P = 0.02), the percentage of regional wall thickening (+13.1%, P= 0.04) and MPR (+0.25%, P = 0.03) over the target area at 6-months compared with baseline. Conclusions. Direct endomyocardial implantation of autologous BM cells significantly improved global LVEF, regional wall thickening and myocardial perfusion reserve, and reduced percentage area of peri-infarct regions in patients with severe CAD. © 2010 Chan et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/125093
ISSN
2015 Impact Factor: 5.752
2015 SCImago Journal Rankings: 3.238
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Sun Chieh Yeh Heart Foundation Fund
S.K. Yee Medical Foundation Grant203217
The Research Grants Council of Hong KongHKU 7357/02M
Funding Information:

This study is supported Sun Chieh Yeh Heart Foundation Fund, S.K. Yee Medical Foundation Grant (Project No. 203217), and The Research Grants Council of Hong Kong (HKU 7357/02M). The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChan, CWSen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorKwong, RYen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorTse, HFen_HK
dc.date.accessioned2010-10-31T11:10:58Z-
dc.date.available2010-10-31T11:10:58Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Cardiovascular Magnetic Resonance, 2010, v. 12 n. 1en_HK
dc.identifier.issn1097-6647en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125093-
dc.description.abstractBackground. Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR). Methods and Results. We compared the interval changes of left ventricular ejection fraction (LVEF), myocardial perfusion reserve and the extent of myocardial scar by using late gadolinium enhancement CMR in 12 patients with severe CAD. CMR was performed at baseline and at 6 months after catheter-based direct endomyocardial autologous BM cell (n = 12) injection to viable ischaemic myocardium as guided by electromechanical mapping. In patients randomized to receive BM cell injection, there was significant decrease in percentage area of peri-infarct regions (-23.6%, P = 0.04) and increase in global LVEF (+9.0%, P = 0.02), the percentage of regional wall thickening (+13.1%, P= 0.04) and MPR (+0.25%, P = 0.03) over the target area at 6-months compared with baseline. Conclusions. Direct endomyocardial implantation of autologous BM cells significantly improved global LVEF, regional wall thickening and myocardial perfusion reserve, and reduced percentage area of peri-infarct regions in patients with severe CAD. © 2010 Chan et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.jcmr-online.com/homeen_HK
dc.relation.ispartofJournal of Cardiovascular Magnetic Resonanceen_HK
dc.rightsJournal of cardiovascular magnetic resonance. Copyright © BioMed Central Ltd.-
dc.subject.meshBone Marrow Transplantation-
dc.subject.meshCoronary Artery Disease - pathology - physiopathology - surgery-
dc.subject.meshCoronary Circulation-
dc.subject.meshMyocardial Infarction - pathology - physiopathology - surgery-
dc.subject.meshMyocardium - pathology-
dc.titleImprovement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1097-6647&volume=12&issue=1 article no. 6&spage=&epage=&date=2010&atitle=Improvement+of+myocardial+perfusion+reserve+detected+by+cardiovascular+magnetic+resonance+after+direct+endomyocardial+implantation+of+autologous+bone+marrow+cells+in+patients+with+severe+coronary+artery+diseaseen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1532-429X-12-6en_HK
dc.identifier.pmid20100336-
dc.identifier.pmcidPMC2845579-
dc.identifier.scopuseid_2-s2.0-77952508764en_HK
dc.identifier.hkuros180765en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952508764&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue1en_HK
dc.identifier.eissn1532-429X-
dc.identifier.isiWOS:000276399600001-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectNeovascularization of ischemic myocardium by autologous bone marrow cells transplantation-
dc.relation.projectDirect intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease-
dc.identifier.scopusauthoridChan, CWS=55209628700en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridKwong, RY=7005246098en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats