File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Do Asian patients have worse lupus?

TitleDo Asian patients have worse lupus?
Authors
KeywordsSystemic lupus erythematosus
Mortality
Damage index
Issue Date2010
PublisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.com
Citation
Lupus, 2010, v. 19 n. 12, p. 1384-1390 How to Cite?
AbstractThe predisposition to and clinical phenotype of systemic lupus erythematosus, an autoimmune disease that is associated with significant morbidity and mortality, are affected by genetic and environmental factors. This article aims to examine whether Asians have worse lupus by reviewing the literature on genetic predisposition and clinical outcomes, including major organ involvement, damage score and mortality in Asian populations compared with other ethnicities. A number of lupus nephritis susceptibility genes have been identified in Asians and White patients, with further variations among different Asian populations. Meta-analysis studies on various Fcγ receptor subtypes revealed that FcγRIIIA-F158 allele, which is associated with low binding affinity to IgG1 and IgG3, predisposed to lupus nephritis in Asian patients. Asian patients were reported to have higher rates of lupus nephritis-associated autoantibodies, lupus nephritis and more active glomerulonephritis compared with White patients. Renal outcome and the level of immunosuppressant use in Asians were comparable to Afro-American Blacks in some studies. Asians were also found to have higher overall damage scores compared with Whites. The difference in mortality between Asian patients and other ethnicities in different geographical regions was found to vary depending on socioeconomic factors such as access to health care. Poverty, education level, cultural and behavioural factors are confounders to ethnicity in determining clinical outcome of systemic lupus erythematosus. © 2010 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/125090
ISSN
2015 Impact Factor: 2.118
2015 SCImago Journal Rankings: 0.878
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, MYen_HK
dc.contributor.authorLi, WLen_HK
dc.date.accessioned2010-10-31T11:10:48Z-
dc.date.available2010-10-31T11:10:48Z-
dc.date.issued2010en_HK
dc.identifier.citationLupus, 2010, v. 19 n. 12, p. 1384-1390en_HK
dc.identifier.issn0961-2033en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125090-
dc.description.abstractThe predisposition to and clinical phenotype of systemic lupus erythematosus, an autoimmune disease that is associated with significant morbidity and mortality, are affected by genetic and environmental factors. This article aims to examine whether Asians have worse lupus by reviewing the literature on genetic predisposition and clinical outcomes, including major organ involvement, damage score and mortality in Asian populations compared with other ethnicities. A number of lupus nephritis susceptibility genes have been identified in Asians and White patients, with further variations among different Asian populations. Meta-analysis studies on various Fcγ receptor subtypes revealed that FcγRIIIA-F158 allele, which is associated with low binding affinity to IgG1 and IgG3, predisposed to lupus nephritis in Asian patients. Asian patients were reported to have higher rates of lupus nephritis-associated autoantibodies, lupus nephritis and more active glomerulonephritis compared with White patients. Renal outcome and the level of immunosuppressant use in Asians were comparable to Afro-American Blacks in some studies. Asians were also found to have higher overall damage scores compared with Whites. The difference in mortality between Asian patients and other ethnicities in different geographical regions was found to vary depending on socioeconomic factors such as access to health care. Poverty, education level, cultural and behavioural factors are confounders to ethnicity in determining clinical outcome of systemic lupus erythematosus. © 2010 The Author(s).en_HK
dc.languageengen_HK
dc.publisherSage Publications Ltd. The Journal's web site is located at http://lup.sagepub.comen_HK
dc.relation.ispartofLupusen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsLupus. Copyright © Sage Publications Ltd.-
dc.subjectSystemic lupus erythematosus-
dc.subjectMortality-
dc.subjectDamage index-
dc.subject.meshAsia - epidemiologyen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshAutoimmunityen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLupus Erythematosus, Systemic - ethnology - etiologyen_HK
dc.subject.meshSurvival Rateen_HK
dc.titleDo Asian patients have worse lupus?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0961-2033&volume=19&issue=12&spage=1384&epage=1390 &date=2010&atitle=Do+Asian+patients+have+worse+lupus?en_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1177/0961203310375832en_HK
dc.identifier.pmid20947546-
dc.identifier.scopuseid_2-s2.0-78649748430en_HK
dc.identifier.hkuros174111en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649748430&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1384en_HK
dc.identifier.epage1390en_HK
dc.identifier.isiWOS:000282970800005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.scopusauthoridLi, WL=37075169700en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats