File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The clinical course of polymyalgia rheumatica in Chinese

TitleThe clinical course of polymyalgia rheumatica in Chinese
Authors
KeywordsAnticyclic citrullinated peptide antibodies
Polymyalgia rheumatica
Rheumatoid arthritis
Issue Date2010
PublisherSpringer-Verlag London Ltd. The Journal's web site is located at http://link.springer.de/link/service/journals/10067/
Citation
Clinical Rheumatology, 2010, v. 29 n. 2, p. 199-203 How to Cite?
AbstractPolymyalgia rheumatica (PMR) is diagnosed based on clinical features that may overlap with other rheumatic conditions like rheumatoid arthritis (RA). Furthermore, a proportion of PMR patients may subsequently evolve into RA. The aim of this study was to examine the clinical characteristics of PMR patients in a Chinese cohort compared to a Caucasian series. Patients diagnosed to have PMR during 1997-2008 were reviewed for clinical features and compared to a reported Caucasian series. Rheumatoid factor (RF) and anticyclic citrullinated peptide (CCP) antibodies were determined by immunonephelometry and enzyme-linked immunosorbent assay, respectively. Forty-four patients of southern Chinese origin were diagnosed to have PMR according to specialist opinion. Seventy-five percent of patients (n = 33) were >65 years of age at diagnosis (mean ± standard deviation, 75.8 ± 9.6 years). The commonest feature at disease onset was elevated erythrocyte sedimentation rate >40 mm/h (100% vs. 95.7%; p = 0.17) and bilateral shoulder pain or stiffness (95.5% vs. 90.8%; p = 0.31), comparable in frequency to the Caucasian cohort. However, Chinese patients had significantly longer duration of symptoms before diagnosis (p < 0.001) but less bilateral upper arm tenderness (p < 0.001) and generalized stiffness (p = 0.01). Twelve (27.3%) patients evolved into RA after a median duration of 2 months from onset of PMR. RF and anti-CCP antibodies were positive in 66.7% and 60% of these patients compared to 9.4% and 6.2%, respectively, among those who did not evolve into RA during the period observed. Chinese patients with PMR have modestly different clinical profile compared to the Caucasian counterpart. RF and anti-CCP antibodies were more likely to be present in those who subsequently developed into RA. © 2009 Clinical Rheumatology.
Persistent Identifierhttp://hdl.handle.net/10722/125081
ISSN
2015 Impact Factor: 2.042
2015 SCImago Journal Rankings: 0.697
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, WLen_HK
dc.contributor.authorLo, Yen_HK
dc.contributor.authorLeung, MHen_HK
dc.contributor.authorWong, WSen_HK
dc.contributor.authorMok, MYen_HK
dc.date.accessioned2010-10-31T11:10:19Z-
dc.date.available2010-10-31T11:10:19Z-
dc.date.issued2010en_HK
dc.identifier.citationClinical Rheumatology, 2010, v. 29 n. 2, p. 199-203en_HK
dc.identifier.issn0770-3198en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125081-
dc.description.abstractPolymyalgia rheumatica (PMR) is diagnosed based on clinical features that may overlap with other rheumatic conditions like rheumatoid arthritis (RA). Furthermore, a proportion of PMR patients may subsequently evolve into RA. The aim of this study was to examine the clinical characteristics of PMR patients in a Chinese cohort compared to a Caucasian series. Patients diagnosed to have PMR during 1997-2008 were reviewed for clinical features and compared to a reported Caucasian series. Rheumatoid factor (RF) and anticyclic citrullinated peptide (CCP) antibodies were determined by immunonephelometry and enzyme-linked immunosorbent assay, respectively. Forty-four patients of southern Chinese origin were diagnosed to have PMR according to specialist opinion. Seventy-five percent of patients (n = 33) were >65 years of age at diagnosis (mean ± standard deviation, 75.8 ± 9.6 years). The commonest feature at disease onset was elevated erythrocyte sedimentation rate >40 mm/h (100% vs. 95.7%; p = 0.17) and bilateral shoulder pain or stiffness (95.5% vs. 90.8%; p = 0.31), comparable in frequency to the Caucasian cohort. However, Chinese patients had significantly longer duration of symptoms before diagnosis (p < 0.001) but less bilateral upper arm tenderness (p < 0.001) and generalized stiffness (p = 0.01). Twelve (27.3%) patients evolved into RA after a median duration of 2 months from onset of PMR. RF and anti-CCP antibodies were positive in 66.7% and 60% of these patients compared to 9.4% and 6.2%, respectively, among those who did not evolve into RA during the period observed. Chinese patients with PMR have modestly different clinical profile compared to the Caucasian counterpart. RF and anti-CCP antibodies were more likely to be present in those who subsequently developed into RA. © 2009 Clinical Rheumatology.en_HK
dc.languageengen_HK
dc.publisherSpringer-Verlag London Ltd. The Journal's web site is located at http://link.springer.de/link/service/journals/10067/en_HK
dc.relation.ispartofClinical Rheumatologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAnticyclic citrullinated peptide antibodiesen_HK
dc.subjectPolymyalgia rheumaticaen_HK
dc.subjectRheumatoid arthritisen_HK
dc.subject.meshAge of Onset-
dc.subject.meshAged-
dc.subject.meshDisease Progression-
dc.subject.meshPolymyalgia Rheumatica - blood - diagnosis - drug therapy - ethnology-
dc.subject.meshPrednisolone - therapeutic use-
dc.titleThe clinical course of polymyalgia rheumatica in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0770-3198&volume=29&issue=2&spage=199&epage=203&date=2010&atitle=The+clinical+course+of+polymyalgia+rheumatica+in+Chinese-
dc.identifier.emailLo, Y:yve_lo@yahoo.com.hken_HK
dc.identifier.emailMok, MY:temy@hkucc.hku.hken_HK
dc.identifier.authorityLo, Y=rp00512en_HK
dc.identifier.authorityMok, MY=rp00490en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1007/s10067-009-1315-8en_HK
dc.identifier.pmid19915991-
dc.identifier.scopuseid_2-s2.0-77949899800en_HK
dc.identifier.hkuros174108en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949899800&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue2en_HK
dc.identifier.spage199en_HK
dc.identifier.epage203en_HK
dc.identifier.isiWOS:000273031600009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, WL=35148159500en_HK
dc.identifier.scopusauthoridLo, Y=16022308000en_HK
dc.identifier.scopusauthoridLeung, MH=16401905000en_HK
dc.identifier.scopusauthoridWong, WS=8737892100en_HK
dc.identifier.scopusauthoridMok, MY=7006024184en_HK
dc.identifier.citeulike6231278-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats