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Article: FLT3/internal tandem duplication subclones in acute myeloid leukemia differ in their engraftment potential in NOD/SCID mice

TitleFLT3/internal tandem duplication subclones in acute myeloid leukemia differ in their engraftment potential in NOD/SCID mice
Authors
KeywordsAML
FLT3/internal tandem duplication
Leukemia stem cells
NOD/SCID mice
Issue Date2010
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukres
Citation
Leukemia Research, 2010, v. 34 n. 1, p. 119-122 How to Cite?
AbstractIn this study, we tested if FLT3/internal tandem duplication (ITD) in acute myeloid leukemia (AML) might occur at different hierarchical stages during leukemogenesis. In 56 AML cases, 10 showed FLT3/ITD (single ITD = 5; multiple ITD = 5). Myeloblasts from seven cases (CD34-selected = 4; unselected = 3) were transplanted into NOD/SCID mice. Five cases engrafted successfully into 14 mice. Two patients carried single FLT3/ITD subclones, which were maintained during primary and secondary transplantations. In three patients with multiple FLT3/ITD subclones, some subclones persisted or expanded while others diminished upon transplantation. Their different engraftment capabilities in NOD/SCID mice supported the proposition that FLT3/ITD might occur at different stages during leukemogenesis. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/125078
ISSN
2015 Impact Factor: 2.606
2015 SCImago Journal Rankings: 1.043
ISI Accession Number ID
Funding AgencyGrant Number
General Research Fund (GRF)HKU 770308M
Lee Hysan Foundation
LKS Faculty of Medicine
Funding Information:

The work was supported in part by the General Research Fund (GRF) (HKU 770308M), a grant from Lee Hysan Foundation (2009) and the Strategy Research Theme on cancer stem cells of the LKS Faculty of Medicine ( HKU).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorCheung, AMSen_HK
dc.contributor.authorChow, HCHen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorLeung, AYHen_HK
dc.date.accessioned2010-10-31T11:10:09Z-
dc.date.available2010-10-31T11:10:09Z-
dc.date.issued2010en_HK
dc.identifier.citationLeukemia Research, 2010, v. 34 n. 1, p. 119-122en_HK
dc.identifier.issn0145-2126en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125078-
dc.description.abstractIn this study, we tested if FLT3/internal tandem duplication (ITD) in acute myeloid leukemia (AML) might occur at different hierarchical stages during leukemogenesis. In 56 AML cases, 10 showed FLT3/ITD (single ITD = 5; multiple ITD = 5). Myeloblasts from seven cases (CD34-selected = 4; unselected = 3) were transplanted into NOD/SCID mice. Five cases engrafted successfully into 14 mice. Two patients carried single FLT3/ITD subclones, which were maintained during primary and secondary transplantations. In three patients with multiple FLT3/ITD subclones, some subclones persisted or expanded while others diminished upon transplantation. Their different engraftment capabilities in NOD/SCID mice supported the proposition that FLT3/ITD might occur at different stages during leukemogenesis. © 2009 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukresen_HK
dc.relation.ispartofLeukemia Researchen_HK
dc.subjectAMLen_HK
dc.subjectFLT3/internal tandem duplicationen_HK
dc.subjectLeukemia stem cellsen_HK
dc.subjectNOD/SCID miceen_HK
dc.titleFLT3/internal tandem duplication subclones in acute myeloid leukemia differ in their engraftment potential in NOD/SCID miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0145-2126&volume=34&issue=1&spage=119&epage=122&date=2010&atitle=FLT3/internal+tandem+duplication+subclones+in+acute+myeloid+leukemia+differ+in+their+engraftment+potential+in+NOD/SCID+miceen_HK
dc.identifier.emailCheung, AMS:h9945256@graduate.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailLeung, AYH:ayhleung@hku.hken_HK
dc.identifier.authorityCheung, AMS=rp01572en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityLeung, AYH=rp00265en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.leukres.2009.07.035en_HK
dc.identifier.pmid19683812-
dc.identifier.scopuseid_2-s2.0-73249122231en_HK
dc.identifier.hkuros180420en_HK
dc.identifier.hkuros200894-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-73249122231&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue1en_HK
dc.identifier.spage119en_HK
dc.identifier.epage122en_HK
dc.identifier.isiWOS:000274528800019-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectIs Jak2V617F mutation a stem cell event in chronic myeloproliferative disease ?-
dc.identifier.scopusauthoridCheung, AMS=36985759800en_HK
dc.identifier.scopusauthoridChow, HCH=7102303391en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridLeung, AYH=7403012668en_HK

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