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Article: Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells

TitleAppl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells
Authors
KeywordsAkt2
Appl1
Duodenum
Pancreas
Stomach
Xenopus
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417
Citation
Developmental Dynamics, 2010, v. 239 n. 8, p. 2198-2207 How to Cite?
AbstractAn understanding of the molecular mechanisms governing the survival of organ progenitor cells in vivo is crucial for in vitro tissue regeneration. Here, we have found that Xenopus appl1 and akt2 share a similar embryonic expression pattern, showing characteristic expression in the central nervous system as well as in the pancreas and part of the stomach/duodenum (SD) at tadpole stages of development. Specific knockdown of appl1 in endoderm or inhibition of akt activity did not affect the formation of endodermal organ primordia at tail bud stages of development, but led to a gut-coiling defect, strong apoptosis in endodermal organs, and pancreas and SD hypoplasia or even aplasia at tadpole stages of development. Furthermore, appl1 is required for akt phosphorylation and akt2 in turn can rescue appl1 knockdown phenotypes. Together, our data suggest that appl1-akt signaling is specifically required for the survival of pancreas and SD progenitor cells in Xenopus laevis embryos. © 2010 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/125055
ISSN
2015 Impact Factor: 2.198
2015 SCImago Journal Rankings: 1.726
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWen, Len_HK
dc.contributor.authorYang, Yen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorWu, Den_HK
dc.contributor.authorChen, Yen_HK
dc.date.accessioned2010-10-31T11:08:55Z-
dc.date.available2010-10-31T11:08:55Z-
dc.date.issued2010en_HK
dc.identifier.citationDevelopmental Dynamics, 2010, v. 239 n. 8, p. 2198-2207en_HK
dc.identifier.issn1058-8388en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125055-
dc.description.abstractAn understanding of the molecular mechanisms governing the survival of organ progenitor cells in vivo is crucial for in vitro tissue regeneration. Here, we have found that Xenopus appl1 and akt2 share a similar embryonic expression pattern, showing characteristic expression in the central nervous system as well as in the pancreas and part of the stomach/duodenum (SD) at tadpole stages of development. Specific knockdown of appl1 in endoderm or inhibition of akt activity did not affect the formation of endodermal organ primordia at tail bud stages of development, but led to a gut-coiling defect, strong apoptosis in endodermal organs, and pancreas and SD hypoplasia or even aplasia at tadpole stages of development. Furthermore, appl1 is required for akt phosphorylation and akt2 in turn can rescue appl1 knockdown phenotypes. Together, our data suggest that appl1-akt signaling is specifically required for the survival of pancreas and SD progenitor cells in Xenopus laevis embryos. © 2010 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38417en_HK
dc.relation.ispartofDevelopmental Dynamicsen_HK
dc.subjectAkt2en_HK
dc.subjectAppl1en_HK
dc.subjectDuodenumen_HK
dc.subjectPancreasen_HK
dc.subjectStomachen_HK
dc.subjectXenopusen_HK
dc.subject.meshAdaptor Proteins, Signal Transducing - physiologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Survivalen_HK
dc.subject.meshDigestive System - cytologyen_HK
dc.subject.meshDuodenum - cytologyen_HK
dc.subject.meshEmbryo, Nonmammalianen_HK
dc.subject.meshPancreas - cytologyen_HK
dc.subject.meshPhosphorylationen_HK
dc.subject.meshProto-Oncogene Proteins c-akt - metabolismen_HK
dc.subject.meshSignal Transductionen_HK
dc.subject.meshStem Cells - cytologyen_HK
dc.subject.meshStomach - cytologyen_HK
dc.subject.meshXenopus Proteins - physiologyen_HK
dc.subject.meshXenopus laevisen_HK
dc.titleAppl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/dvdy.22356en_HK
dc.identifier.pmid20568240en_HK
dc.identifier.scopuseid_2-s2.0-77954983113en_HK
dc.identifier.hkuros175937en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954983113&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume239en_HK
dc.identifier.issue8en_HK
dc.identifier.spage2198en_HK
dc.identifier.epage2207en_HK
dc.identifier.isiWOS:000280716500006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWen, L=36135119800en_HK
dc.identifier.scopusauthoridYang, Y=7409382210en_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridWu, D=7404297751en_HK
dc.identifier.scopusauthoridChen, Y=7601445337en_HK

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