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Article: Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infection
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TitleConcurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infection
 
AuthorsTo, KKW1
Wong, SSY1
Li, IWS1
Hung, IFN1
Tse, H1
Woo, PCY1
Chan, KH1
Yuen, KY1
 
Issue Date2010
 
PublisherB M J Publishing Group. The Journal's web site is located at http://www.postgradmedj.com
 
CitationPostgraduate Medical Journal, 2010, v. 86 n. 1019, p. 515-521 [How to Cite?]
DOI: http://dx.doi.org/10.1136/pgmj.2009.096206
 
AbstractPurpose of study: The demographics, clinical features and outcome of patients with pandemic influenza A (H1N1) 2009 infection were compared with a concurrent cohort of patients with seasonal influenza A infection. Study design: The clinical and microbiological data of hospitalised adult patients admitted between 29 June and 28 October 2009, with pandemic A (H1N1) 2009 or seasonal influenza A infection, were analysed. Results: A total of 186 patients including 69 pandemic A (H1N1) and 117 seasonal influenza were analysed. The majority (75%) under 50 years of age had pandemic A (H1N1). Compared with seasonal influenza, pandemic A (H1N1) patients were younger (median age 47 years vs 76 years, p<0.001), less likely to have lower respiratory tract symptoms (46.4% vs 66.7%, p=0.007), but more likely to be obese (5.8% vs 0%, p=0.018), pregnant (7.2% vs 0.9%, p=0.027) or have no underlying predisposing factors (24.6% vs 5.1%, p<0.001). Patients with pandemic A (H1N1) were more likely to receive oseltamivir (91.3% vs 40.2%, p<0.001), but less likely to receive antibiotics (75.4% vs 90.6%, p=0.005). Respiratory failure was the reason for intensive care unit admission for all four patients with pandemic A (H1N1), but only for one of three patients with seasonal influenza. There were no statistical significant differences in the rate of intensive care unit admission or death. Conclusions: In addition to age, several clinical parameters were different between pandemic A (H1N1) and seasonal influenza. However, since both seasonal and pandemic influenza can lead to significant morbidity and mortality, the impact of pre-existing seasonal influenza should not be underestimated during the pandemic period.
 
ISSN0032-5473
2012 Impact Factor: 1.608
2012 SCImago Journal Rankings: 0.542
 
DOIhttp://dx.doi.org/10.1136/pgmj.2009.096206
 
ISI Accession Number IDWOS:000282632800002
Funding AgencyGrant Number
Providence Foundation Limited
University Grant Council
Research Fund for the Control of Infectious Diseases (RICID) of the Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

Providence Foundation Limited in memory of the late Dr Lui Hac Minh, the University Grant Council, and the Research Fund for the Control of Infectious Diseases (RICID) of the Food and Health Bureau of the Hong Kong SAR Government

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTo, KKW
 
dc.contributor.authorWong, SSY
 
dc.contributor.authorLi, IWS
 
dc.contributor.authorHung, IFN
 
dc.contributor.authorTse, H
 
dc.contributor.authorWoo, PCY
 
dc.contributor.authorChan, KH
 
dc.contributor.authorYuen, KY
 
dc.date.accessioned2010-10-31T11:08:15Z
 
dc.date.available2010-10-31T11:08:15Z
 
dc.date.issued2010
 
dc.description.abstractPurpose of study: The demographics, clinical features and outcome of patients with pandemic influenza A (H1N1) 2009 infection were compared with a concurrent cohort of patients with seasonal influenza A infection. Study design: The clinical and microbiological data of hospitalised adult patients admitted between 29 June and 28 October 2009, with pandemic A (H1N1) 2009 or seasonal influenza A infection, were analysed. Results: A total of 186 patients including 69 pandemic A (H1N1) and 117 seasonal influenza were analysed. The majority (75%) under 50 years of age had pandemic A (H1N1). Compared with seasonal influenza, pandemic A (H1N1) patients were younger (median age 47 years vs 76 years, p<0.001), less likely to have lower respiratory tract symptoms (46.4% vs 66.7%, p=0.007), but more likely to be obese (5.8% vs 0%, p=0.018), pregnant (7.2% vs 0.9%, p=0.027) or have no underlying predisposing factors (24.6% vs 5.1%, p<0.001). Patients with pandemic A (H1N1) were more likely to receive oseltamivir (91.3% vs 40.2%, p<0.001), but less likely to receive antibiotics (75.4% vs 90.6%, p=0.005). Respiratory failure was the reason for intensive care unit admission for all four patients with pandemic A (H1N1), but only for one of three patients with seasonal influenza. There were no statistical significant differences in the rate of intensive care unit admission or death. Conclusions: In addition to age, several clinical parameters were different between pandemic A (H1N1) and seasonal influenza. However, since both seasonal and pandemic influenza can lead to significant morbidity and mortality, the impact of pre-existing seasonal influenza should not be underestimated during the pandemic period.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationPostgraduate Medical Journal, 2010, v. 86 n. 1019, p. 515-521 [How to Cite?]
DOI: http://dx.doi.org/10.1136/pgmj.2009.096206
 
dc.identifier.doihttp://dx.doi.org/10.1136/pgmj.2009.096206
 
dc.identifier.eissn1469-0756
 
dc.identifier.epage521
 
dc.identifier.hkuros179943
 
dc.identifier.isiWOS:000282632800002
Funding AgencyGrant Number
Providence Foundation Limited
University Grant Council
Research Fund for the Control of Infectious Diseases (RICID) of the Food and Health Bureau of the Hong Kong SAR Government
Funding Information:

Providence Foundation Limited in memory of the late Dr Lui Hac Minh, the University Grant Council, and the Research Fund for the Control of Infectious Diseases (RICID) of the Food and Health Bureau of the Hong Kong SAR Government

 
dc.identifier.issn0032-5473
2012 Impact Factor: 1.608
2012 SCImago Journal Rankings: 0.542
 
dc.identifier.issue1019
 
dc.identifier.openurl
 
dc.identifier.pmid20693151
 
dc.identifier.scopuseid_2-s2.0-77956935174
 
dc.identifier.spage515
 
dc.identifier.urihttp://hdl.handle.net/10722/125043
 
dc.identifier.volume86
 
dc.languageeng
 
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.postgradmedj.com
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofPostgraduate Medical Journal
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.titleConcurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infection
 
dc.typeArticle
 
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<contributor.author>Tse, H</contributor.author>
<contributor.author>Woo, PCY</contributor.author>
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Author Affiliations
  1. The University of Hong Kong