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Article: Endothelial lipase and reverse cholesterol transport in type 2 diabetes mellitus
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TitleEndothelial lipase and reverse cholesterol transport in type 2 diabetes mellitus
 
AuthorsShiu, SWM1
Zhou, H1
Wong, Y1
Tan, KCB1
 
KeywordsCholesterol efflux
Endothelial lipase
Reverse cholesterol transport
 
Issue Date2010
 
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=2040-1116&site=1
 
CitationJournal Of Diabetes Investigation, 2010, v. 1 n. 3, p. 111-116 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.2040-1124.2010.00016.x
 
AbstractAims/Introduction: Endothelial lipase (EL) plays an important role in high-density lipoprotein (HDL) metabolism and experimental data suggest that EL might be proatherogenic. We have investigated whether serum EL concentration is associated with changes in serum capacity to induce cholesterol efflux and arterial stiffness in type 2 diabetes. Materials and Methods: Serum EL was assayed by ELISA in 172 diabetic patients and 175 controls. The ability of serum to induce cholesterol efflux was measured using a cell culture system and arterial stiffness was determined by measuring pulse wave velocity (PWV) between carotid and femoral arteries. Results: Diabetic patients had significantly higher C-reactive protein (CRP) and EL (27.7 ± 16.6 ng/mL vs 24.0 ± 11.3, P < 0.05). Cholesterol efflux to serum mediated through scavenger receptor class B type I was impaired (15.1 ± 2.5% vs 16.7 ± 3.1, respectively, P < 0.01). In controls, serum EL correlated with cholesterol efflux to serum (r =)0.16, P = 0.025), but only a trend was seen in the diabetic patients. Linear regression showed that in controls, HDL, serum EL and waist circumference were major independent determinants of cholesterol efflux; whereas in the diabetic cohort, the major independent determinants of cholesterol efflux were HDL, CRP and age. PWV was increased in the diabetic patients (P < 0.01), but no association between serum EL and PWV was seen in either groups. Conclusions: Serum EL was increased in diabetic patients, but impaired serum capacity to induce cholesterol efflux in these patients was mainly related to low HDL and subclinical inflammation. © 2010 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd.
 
ISSN2040-1116
2013 Impact Factor: 1.496
 
DOIhttp://dx.doi.org/10.1111/j.2040-1124.2010.00016.x
 
ISI Accession Number IDWOS:000289906300006
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorShiu, SWM
 
dc.contributor.authorZhou, H
 
dc.contributor.authorWong, Y
 
dc.contributor.authorTan, KCB
 
dc.date.accessioned2010-10-31T11:08:09Z
 
dc.date.available2010-10-31T11:08:09Z
 
dc.date.issued2010
 
dc.description.abstractAims/Introduction: Endothelial lipase (EL) plays an important role in high-density lipoprotein (HDL) metabolism and experimental data suggest that EL might be proatherogenic. We have investigated whether serum EL concentration is associated with changes in serum capacity to induce cholesterol efflux and arterial stiffness in type 2 diabetes. Materials and Methods: Serum EL was assayed by ELISA in 172 diabetic patients and 175 controls. The ability of serum to induce cholesterol efflux was measured using a cell culture system and arterial stiffness was determined by measuring pulse wave velocity (PWV) between carotid and femoral arteries. Results: Diabetic patients had significantly higher C-reactive protein (CRP) and EL (27.7 ± 16.6 ng/mL vs 24.0 ± 11.3, P < 0.05). Cholesterol efflux to serum mediated through scavenger receptor class B type I was impaired (15.1 ± 2.5% vs 16.7 ± 3.1, respectively, P < 0.01). In controls, serum EL correlated with cholesterol efflux to serum (r =)0.16, P = 0.025), but only a trend was seen in the diabetic patients. Linear regression showed that in controls, HDL, serum EL and waist circumference were major independent determinants of cholesterol efflux; whereas in the diabetic cohort, the major independent determinants of cholesterol efflux were HDL, CRP and age. PWV was increased in the diabetic patients (P < 0.01), but no association between serum EL and PWV was seen in either groups. Conclusions: Serum EL was increased in diabetic patients, but impaired serum capacity to induce cholesterol efflux in these patients was mainly related to low HDL and subclinical inflammation. © 2010 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Diabetes Investigation, 2010, v. 1 n. 3, p. 111-116 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.2040-1124.2010.00016.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.2040-1124.2010.00016.x
 
dc.identifier.epage116
 
dc.identifier.hkuros174658
 
dc.identifier.isiWOS:000289906300006
 
dc.identifier.issn2040-1116
2013 Impact Factor: 1.496
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.scopuseid_2-s2.0-79953752962
 
dc.identifier.spage111
 
dc.identifier.urihttp://hdl.handle.net/10722/125041
 
dc.identifier.volume1
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=2040-1116&site=1
 
dc.publisher.placeAustralia
 
dc.relation.ispartofJournal of Diabetes Investigation
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.subjectCholesterol efflux
 
dc.subjectEndothelial lipase
 
dc.subjectReverse cholesterol transport
 
dc.titleEndothelial lipase and reverse cholesterol transport in type 2 diabetes mellitus
 
dc.typeArticle
 
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<contributor.author>Wong, Y</contributor.author>
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<description.abstract>Aims/Introduction: Endothelial lipase (EL) plays an important role in high-density lipoprotein (HDL) metabolism and experimental data suggest that EL might be proatherogenic. We have investigated whether serum EL concentration is associated with changes in serum capacity to induce cholesterol efflux and arterial stiffness in type 2 diabetes. Materials and Methods: Serum EL was assayed by ELISA in 172 diabetic patients and 175 controls. The ability of serum to induce cholesterol efflux was measured using a cell culture system and arterial stiffness was determined by measuring pulse wave velocity (PWV) between carotid and femoral arteries. Results: Diabetic patients had significantly higher C-reactive protein (CRP) and EL (27.7 &#177; 16.6 ng/mL vs 24.0 &#177; 11.3, P &lt; 0.05). Cholesterol efflux to serum mediated through scavenger receptor class B type I was impaired (15.1 &#177; 2.5% vs 16.7 &#177; 3.1, respectively, P &lt; 0.01). In controls, serum EL correlated with cholesterol efflux to serum (r =)0.16, P = 0.025), but only a trend was seen in the diabetic patients. Linear regression showed that in controls, HDL, serum EL and waist circumference were major independent determinants of cholesterol efflux; whereas in the diabetic cohort, the major independent determinants of cholesterol efflux were HDL, CRP and age. PWV was increased in the diabetic patients (P &lt; 0.01), but no association between serum EL and PWV was seen in either groups. Conclusions: Serum EL was increased in diabetic patients, but impaired serum capacity to induce cholesterol efflux in these patients was mainly related to low HDL and subclinical inflammation. &#169; 2010 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong