Article: Practical limitations of convalescent plasma collection: A case scenario in pandemic preparation for influenza A (H1N1) infection

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TitlePractical limitations of convalescent plasma collection: A case scenario in pandemic preparation for influenza A (H1N1) infection
AuthorsWong, HK
Lee, CK1
Hung, IFN
Leung, JNS
Hong, J
Yuen, KY
Lin, CK
Issue Date2010
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/TRF
CitationTransfusion, 2010, v. 50 n. 9, p. 1967-1971 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1537-2995.2010.02651.x
AbstractBACKGROUND: To ensure a good preparedness for pandemic influenza A (H1N1), a study was conducted to investigate clinical effectiveness of hyperimmune intravenous globulin (H-IVIG) prepared from convalescent plasma donated by recovered patients. This article reports on the outcome of the collection phase of the study. STUDY DESIGN AND METHODS: Starting on August 26, 2009, all confirmed patients aged between 18 and 55 years were invited for participation into the study and screen for plasma donation eligibility. Effective September 17, 2009, those who were unwilling to consider screening for plasma were asked to donate whole blood. Plasma collected or separated from whole blood had to demonstrate sufficient neutralization antibodies titers of 40 or more before being channeled for H-IVIG production. RESULTS: By October 31, 2009, a total of 9101 persons were successfully contacted. A total of 1309 screening and 619 whole blood donation appointments were made. In the former 786 (60.0%) attended screening but only 301 could donate plasma by apheresis because of failure to meet blood donation eligibility criteria, failed laboratory tests, insufficient neutralization antibody titers, and inability to make the apheresis appointment. For those who opted for whole blood donation, 379 (61.2%) had attended and donated. A total of 276 L of convalescent plasma with sufficient neutralization antibodies titers was collected for H-IVIG production. DISCUSSION: The study highlighted a number of practical limitations in convalescent plasma collection programs and plasmapheresis is always the preferred mode of collection. It provided valuable learning experience for the blood transfusion service in future planning when large-scale collection is required. © 2010 American Association of Blood Banks.
ISSN0041-1132
2011 Impact Factor: 3.217
2011 SCImago Journal Rankings: 0.272
DOIhttp://dx.doi.org/10.1111/j.1537-2995.2010.02651.x
ISI Accession Number IDWOS:000281553200017
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWong, HK
dc.contributor.authorLee, CK
dc.contributor.authorHung, IFN
dc.contributor.authorLeung, JNS
dc.contributor.authorHong, J
dc.contributor.authorYuen, KY
dc.contributor.authorLin, CK
dc.date.accessioned2010-10-31T11:07:52Z
dc.date.available2010-10-31T11:07:52Z
dc.date.issued2010
dc.description.abstractBACKGROUND: To ensure a good preparedness for pandemic influenza A (H1N1), a study was conducted to investigate clinical effectiveness of hyperimmune intravenous globulin (H-IVIG) prepared from convalescent plasma donated by recovered patients. This article reports on the outcome of the collection phase of the study. STUDY DESIGN AND METHODS: Starting on August 26, 2009, all confirmed patients aged between 18 and 55 years were invited for participation into the study and screen for plasma donation eligibility. Effective September 17, 2009, those who were unwilling to consider screening for plasma were asked to donate whole blood. Plasma collected or separated from whole blood had to demonstrate sufficient neutralization antibodies titers of 40 or more before being channeled for H-IVIG production. RESULTS: By October 31, 2009, a total of 9101 persons were successfully contacted. A total of 1309 screening and 619 whole blood donation appointments were made. In the former 786 (60.0%) attended screening but only 301 could donate plasma by apheresis because of failure to meet blood donation eligibility criteria, failed laboratory tests, insufficient neutralization antibody titers, and inability to make the apheresis appointment. For those who opted for whole blood donation, 379 (61.2%) had attended and donated. A total of 276 L of convalescent plasma with sufficient neutralization antibodies titers was collected for H-IVIG production. DISCUSSION: The study highlighted a number of practical limitations in convalescent plasma collection programs and plasmapheresis is always the preferred mode of collection. It provided valuable learning experience for the blood transfusion service in future planning when large-scale collection is required. © 2010 American Association of Blood Banks.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationTransfusion, 2010, v. 50 n. 9, p. 1967-1971 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1537-2995.2010.02651.x
dc.identifier.citeulike7868693
dc.identifier.doihttp://dx.doi.org/10.1111/j.1537-2995.2010.02651.x
dc.identifier.epage1971
dc.identifier.hkuros173888
dc.identifier.isiWOS:000281553200017
dc.identifier.issn0041-1132
2011 Impact Factor: 3.217
2011 SCImago Journal Rankings: 0.272
dc.identifier.issue9
dc.identifier.openurl
dc.identifier.pmid20412524
dc.identifier.scopuseid_2-s2.0-77956324536
dc.identifier.spage1967
dc.identifier.urihttp://hdl.handle.net/10722/125036
dc.identifier.volume50
dc.languageeng
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/TRF
dc.publisher.placeUnited States
dc.relation.ispartofTransfusion
dc.relation.referencesReferences in Scopus
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshBlood Donors - statistics & numerical data
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunoglobulins - immunology - isolation & purification - therapeutic use
dc.subject.meshInfluenza Vaccines - immunology
dc.subject.meshInfluenza, Human - immunology - prevention & control
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPlasma - immunology
dc.subject.meshYoung Adult
dc.titlePractical limitations of convalescent plasma collection: A case scenario in pandemic preparation for influenza A (H1N1) infection
dc.typeArticle
Author Affiliations
  1. Hong Kong Red Cross Blood Transfusion Service