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Article: Practical limitations of convalescent plasma collection: A case scenario in pandemic preparation for influenza A (H1N1) infection

TitlePractical limitations of convalescent plasma collection: A case scenario in pandemic preparation for influenza A (H1N1) infection
Authors
Issue Date2010
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/TRF
Citation
Transfusion, 2010, v. 50 n. 9, p. 1967-1971 How to Cite?
AbstractBACKGROUND: To ensure a good preparedness for pandemic influenza A (H1N1), a study was conducted to investigate clinical effectiveness of hyperimmune intravenous globulin (H-IVIG) prepared from convalescent plasma donated by recovered patients. This article reports on the outcome of the collection phase of the study. STUDY DESIGN AND METHODS: Starting on August 26, 2009, all confirmed patients aged between 18 and 55 years were invited for participation into the study and screen for plasma donation eligibility. Effective September 17, 2009, those who were unwilling to consider screening for plasma were asked to donate whole blood. Plasma collected or separated from whole blood had to demonstrate sufficient neutralization antibodies titers of 40 or more before being channeled for H-IVIG production. RESULTS: By October 31, 2009, a total of 9101 persons were successfully contacted. A total of 1309 screening and 619 whole blood donation appointments were made. In the former 786 (60.0%) attended screening but only 301 could donate plasma by apheresis because of failure to meet blood donation eligibility criteria, failed laboratory tests, insufficient neutralization antibody titers, and inability to make the apheresis appointment. For those who opted for whole blood donation, 379 (61.2%) had attended and donated. A total of 276 L of convalescent plasma with sufficient neutralization antibodies titers was collected for H-IVIG production. DISCUSSION: The study highlighted a number of practical limitations in convalescent plasma collection programs and plasmapheresis is always the preferred mode of collection. It provided valuable learning experience for the blood transfusion service in future planning when large-scale collection is required. © 2010 American Association of Blood Banks.
Persistent Identifierhttp://hdl.handle.net/10722/125036
ISSN
2014 Impact Factor: 3.225
2014 SCImago Journal Rankings: 1.144
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, HKen_HK
dc.contributor.authorLee, CKen_HK
dc.contributor.authorHung, IFNen_HK
dc.contributor.authorLeung, JNSen_HK
dc.contributor.authorHong, Jen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorLin, CKen_HK
dc.date.accessioned2010-10-31T11:07:52Z-
dc.date.available2010-10-31T11:07:52Z-
dc.date.issued2010en_HK
dc.identifier.citationTransfusion, 2010, v. 50 n. 9, p. 1967-1971en_HK
dc.identifier.issn0041-1132en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125036-
dc.description.abstractBACKGROUND: To ensure a good preparedness for pandemic influenza A (H1N1), a study was conducted to investigate clinical effectiveness of hyperimmune intravenous globulin (H-IVIG) prepared from convalescent plasma donated by recovered patients. This article reports on the outcome of the collection phase of the study. STUDY DESIGN AND METHODS: Starting on August 26, 2009, all confirmed patients aged between 18 and 55 years were invited for participation into the study and screen for plasma donation eligibility. Effective September 17, 2009, those who were unwilling to consider screening for plasma were asked to donate whole blood. Plasma collected or separated from whole blood had to demonstrate sufficient neutralization antibodies titers of 40 or more before being channeled for H-IVIG production. RESULTS: By October 31, 2009, a total of 9101 persons were successfully contacted. A total of 1309 screening and 619 whole blood donation appointments were made. In the former 786 (60.0%) attended screening but only 301 could donate plasma by apheresis because of failure to meet blood donation eligibility criteria, failed laboratory tests, insufficient neutralization antibody titers, and inability to make the apheresis appointment. For those who opted for whole blood donation, 379 (61.2%) had attended and donated. A total of 276 L of convalescent plasma with sufficient neutralization antibodies titers was collected for H-IVIG production. DISCUSSION: The study highlighted a number of practical limitations in convalescent plasma collection programs and plasmapheresis is always the preferred mode of collection. It provided valuable learning experience for the blood transfusion service in future planning when large-scale collection is required. © 2010 American Association of Blood Banks.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/TRFen_HK
dc.relation.ispartofTransfusionen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshBlood Donors - statistics & numerical dataen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoglobulins - immunology - isolation & purification - therapeutic useen_HK
dc.subject.meshInfluenza Vaccines - immunologyen_HK
dc.subject.meshInfluenza, Human - immunology - prevention & controlen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPlasma - immunologyen_HK
dc.subject.meshYoung Adulten_HK
dc.titlePractical limitations of convalescent plasma collection: A case scenario in pandemic preparation for influenza A (H1N1) infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0041-1132&volume=&spage=&epage=&date=2010&atitle=Practical+limitations+of+convalescent+plasma+collection:+a+case+scenario+in+pandemic+preparation+for+influenza+A+(H1N1)+infection.en_HK
dc.identifier.emailHung, IFN:ivanhung@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityHung, IFN=rp00508en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1537-2995.2010.02651.xen_HK
dc.identifier.pmid20412524en_HK
dc.identifier.scopuseid_2-s2.0-77956324536en_HK
dc.identifier.hkuros173888en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956324536&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1967en_HK
dc.identifier.epage1971en_HK
dc.identifier.isiWOS:000281553200017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, HK=37022075400en_HK
dc.identifier.scopusauthoridLee, CK=36087620900en_HK
dc.identifier.scopusauthoridHung, IFN=7006103457en_HK
dc.identifier.scopusauthoridLeung, JNS=37021587000en_HK
dc.identifier.scopusauthoridHong, J=7404118670en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridLin, CK=12752556900en_HK
dc.identifier.citeulike7868693-

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