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Article: Practical limitations of convalescent plasma collection: A case scenario in pandemic preparation for influenza A (H1N1) infection
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TitlePractical limitations of convalescent plasma collection: A case scenario in pandemic preparation for influenza A (H1N1) infection
 
AuthorsWong, HK
Lee, CK1
Hung, IFN
Leung, JNS
Hong, J
Yuen, KY
Lin, CK
 
Issue Date2010
 
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/TRF
 
CitationTransfusion, 2010, v. 50 n. 9, p. 1967-1971 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1537-2995.2010.02651.x
 
AbstractBACKGROUND: To ensure a good preparedness for pandemic influenza A (H1N1), a study was conducted to investigate clinical effectiveness of hyperimmune intravenous globulin (H-IVIG) prepared from convalescent plasma donated by recovered patients. This article reports on the outcome of the collection phase of the study. STUDY DESIGN AND METHODS: Starting on August 26, 2009, all confirmed patients aged between 18 and 55 years were invited for participation into the study and screen for plasma donation eligibility. Effective September 17, 2009, those who were unwilling to consider screening for plasma were asked to donate whole blood. Plasma collected or separated from whole blood had to demonstrate sufficient neutralization antibodies titers of 40 or more before being channeled for H-IVIG production. RESULTS: By October 31, 2009, a total of 9101 persons were successfully contacted. A total of 1309 screening and 619 whole blood donation appointments were made. In the former 786 (60.0%) attended screening but only 301 could donate plasma by apheresis because of failure to meet blood donation eligibility criteria, failed laboratory tests, insufficient neutralization antibody titers, and inability to make the apheresis appointment. For those who opted for whole blood donation, 379 (61.2%) had attended and donated. A total of 276 L of convalescent plasma with sufficient neutralization antibodies titers was collected for H-IVIG production. DISCUSSION: The study highlighted a number of practical limitations in convalescent plasma collection programs and plasmapheresis is always the preferred mode of collection. It provided valuable learning experience for the blood transfusion service in future planning when large-scale collection is required. © 2010 American Association of Blood Banks.
 
ISSN0041-1132
2012 Impact Factor: 3.526
2012 SCImago Journal Rankings: 1.180
 
DOIhttp://dx.doi.org/10.1111/j.1537-2995.2010.02651.x
 
ISI Accession Number IDWOS:000281553200017
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, HK
 
dc.contributor.authorLee, CK
 
dc.contributor.authorHung, IFN
 
dc.contributor.authorLeung, JNS
 
dc.contributor.authorHong, J
 
dc.contributor.authorYuen, KY
 
dc.contributor.authorLin, CK
 
dc.date.accessioned2010-10-31T11:07:52Z
 
dc.date.available2010-10-31T11:07:52Z
 
dc.date.issued2010
 
dc.description.abstractBACKGROUND: To ensure a good preparedness for pandemic influenza A (H1N1), a study was conducted to investigate clinical effectiveness of hyperimmune intravenous globulin (H-IVIG) prepared from convalescent plasma donated by recovered patients. This article reports on the outcome of the collection phase of the study. STUDY DESIGN AND METHODS: Starting on August 26, 2009, all confirmed patients aged between 18 and 55 years were invited for participation into the study and screen for plasma donation eligibility. Effective September 17, 2009, those who were unwilling to consider screening for plasma were asked to donate whole blood. Plasma collected or separated from whole blood had to demonstrate sufficient neutralization antibodies titers of 40 or more before being channeled for H-IVIG production. RESULTS: By October 31, 2009, a total of 9101 persons were successfully contacted. A total of 1309 screening and 619 whole blood donation appointments were made. In the former 786 (60.0%) attended screening but only 301 could donate plasma by apheresis because of failure to meet blood donation eligibility criteria, failed laboratory tests, insufficient neutralization antibody titers, and inability to make the apheresis appointment. For those who opted for whole blood donation, 379 (61.2%) had attended and donated. A total of 276 L of convalescent plasma with sufficient neutralization antibodies titers was collected for H-IVIG production. DISCUSSION: The study highlighted a number of practical limitations in convalescent plasma collection programs and plasmapheresis is always the preferred mode of collection. It provided valuable learning experience for the blood transfusion service in future planning when large-scale collection is required. © 2010 American Association of Blood Banks.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationTransfusion, 2010, v. 50 n. 9, p. 1967-1971 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1537-2995.2010.02651.x
 
dc.identifier.citeulike7868693
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1537-2995.2010.02651.x
 
dc.identifier.epage1971
 
dc.identifier.hkuros173888
 
dc.identifier.isiWOS:000281553200017
 
dc.identifier.issn0041-1132
2012 Impact Factor: 3.526
2012 SCImago Journal Rankings: 1.180
 
dc.identifier.issue9
 
dc.identifier.openurl
 
dc.identifier.pmid20412524
 
dc.identifier.scopuseid_2-s2.0-77956324536
 
dc.identifier.spage1967
 
dc.identifier.urihttp://hdl.handle.net/10722/125036
 
dc.identifier.volume50
 
dc.languageeng
 
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/TRF
 
dc.publisher.placeUnited States
 
dc.relation.ispartofTransfusion
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshAdult
 
dc.subject.meshBlood Donors - statistics & numerical data
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshImmunoglobulins - immunology - isolation & purification - therapeutic use
 
dc.subject.meshInfluenza Vaccines - immunology
 
dc.subject.meshInfluenza, Human - immunology - prevention & control
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPlasma - immunology
 
dc.subject.meshYoung Adult
 
dc.titlePractical limitations of convalescent plasma collection: A case scenario in pandemic preparation for influenza A (H1N1) infection
 
dc.typeArticle
 
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Author Affiliations
  1. Hong Kong Red Cross Blood Transfusion Service