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Article: The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus
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TitleThe relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus
 
AuthorsMok, MY1
Wu, HJ1
Lo, Y1
Lau, CS1
 
KeywordsCytokines
Disease activity
Systemic lupus erythematosus
 
Issue Date2010
 
PublisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
 
CitationJournal Of Rheumatology, 2010, v. 37 n. 10, p. 2046-2052 [How to Cite?]
DOI: http://dx.doi.org/10.3899/jrheum.100293
 
AbstractObjective. Interleukin 17 (IL-17) was recently linked to pathogenesis of systemic lupus erythematosus (SLE), but its relation to disease activity has not been well characterized. We examined the relation between serum levels of Th17 (IL-17, IL-23), Th1 (IL-12, interferon-γ), Th2 (IL-10, IL-6, IL-4) cytokines and disease activity in patients with SLE. Methods. Serum cytokines were measured by enzyme linked immunosorbent assays. Disease activity was determined by SLE disease activity index (SLEDAI), anti-dsDNA antibody, and C3 and C4 levels. Results. Serum levels of IL-17 (p < 0.001), IL-6 (p = 0.006) and IL-10 (p < 0.001) were higher in SLE patients (n = 70) compared to healthy controls (n = 36). Higher serum IL-23 level was found in patients with active disease with cutaneous manifestations (p = 0.004) and serositis (p = 0.04) compared to those without. Serum IL-17 level above the detection limit was more frequently found in patients who had active lupus nephritis (11/23, 47.8%) (p = 0.002), nonrenal active disease (9/15, 60%) (p = 0.001), and inactive lupus (21/32, 65.6%) (p < 0.001) compared to healthy controls (0%). Serum IL-17 levels were otherwise comparable between these 3 groups of patients and were not related to SLEDAI, glomerular filtration rate, activity or chronicity score and ISN/RPS criteria class among patients with active lupus nephritis. There was no significant correlation between serum IL-17/IL-23 and Th1 or Th2 cytokine levels. Conclusion. SLE patients had higher serum IL-17 levels than healthy controls. Elevated serum IL-23 was found in patients with inflammatory manifestations including cutaneous involvement and serositis. The lack of correlation between Th17, Th1, and Th2 cytokines suggested independent regulatory mechanisms for these cytokines. The Journal of Rheumatology Copyright © 2010. All rights reserved.
 
ISSN0315-162X
2012 Impact Factor: 3.258
2012 SCImago Journal Rankings: 1.304
 
DOIhttp://dx.doi.org/10.3899/jrheum.100293
 
ISI Accession Number IDWOS:000282864400012
Funding AgencyGrant Number
University of Hong Kong20084159001
Funding Information:

Supported by Seed Funding Programme for Basic Research (20084159001) from the University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMok, MY
 
dc.contributor.authorWu, HJ
 
dc.contributor.authorLo, Y
 
dc.contributor.authorLau, CS
 
dc.date.accessioned2010-10-31T11:07:36Z
 
dc.date.available2010-10-31T11:07:36Z
 
dc.date.issued2010
 
dc.description.abstractObjective. Interleukin 17 (IL-17) was recently linked to pathogenesis of systemic lupus erythematosus (SLE), but its relation to disease activity has not been well characterized. We examined the relation between serum levels of Th17 (IL-17, IL-23), Th1 (IL-12, interferon-γ), Th2 (IL-10, IL-6, IL-4) cytokines and disease activity in patients with SLE. Methods. Serum cytokines were measured by enzyme linked immunosorbent assays. Disease activity was determined by SLE disease activity index (SLEDAI), anti-dsDNA antibody, and C3 and C4 levels. Results. Serum levels of IL-17 (p < 0.001), IL-6 (p = 0.006) and IL-10 (p < 0.001) were higher in SLE patients (n = 70) compared to healthy controls (n = 36). Higher serum IL-23 level was found in patients with active disease with cutaneous manifestations (p = 0.004) and serositis (p = 0.04) compared to those without. Serum IL-17 level above the detection limit was more frequently found in patients who had active lupus nephritis (11/23, 47.8%) (p = 0.002), nonrenal active disease (9/15, 60%) (p = 0.001), and inactive lupus (21/32, 65.6%) (p < 0.001) compared to healthy controls (0%). Serum IL-17 levels were otherwise comparable between these 3 groups of patients and were not related to SLEDAI, glomerular filtration rate, activity or chronicity score and ISN/RPS criteria class among patients with active lupus nephritis. There was no significant correlation between serum IL-17/IL-23 and Th1 or Th2 cytokine levels. Conclusion. SLE patients had higher serum IL-17 levels than healthy controls. Elevated serum IL-23 was found in patients with inflammatory manifestations including cutaneous involvement and serositis. The lack of correlation between Th17, Th1, and Th2 cytokines suggested independent regulatory mechanisms for these cytokines. The Journal of Rheumatology Copyright © 2010. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Rheumatology, 2010, v. 37 n. 10, p. 2046-2052 [How to Cite?]
DOI: http://dx.doi.org/10.3899/jrheum.100293
 
dc.identifier.doihttp://dx.doi.org/10.3899/jrheum.100293
 
dc.identifier.epage2052
 
dc.identifier.hkuros174741
 
dc.identifier.hkuros195385
 
dc.identifier.hkuros195401
 
dc.identifier.isiWOS:000282864400012
Funding AgencyGrant Number
University of Hong Kong20084159001
Funding Information:

Supported by Seed Funding Programme for Basic Research (20084159001) from the University of Hong Kong.

 
dc.identifier.issn0315-162X
2012 Impact Factor: 3.258
2012 SCImago Journal Rankings: 1.304
 
dc.identifier.issue10
 
dc.identifier.openurl
 
dc.identifier.pmid20682672
 
dc.identifier.scopuseid_2-s2.0-77957867731
 
dc.identifier.spage2046
 
dc.identifier.urihttp://hdl.handle.net/10722/125031
 
dc.identifier.volume37
 
dc.languageeng
 
dc.publisherJournal of Rheumatology Publishing Co Ltd. The Journal's web site is located at http://www.jrheum.com
 
dc.publisher.placeCanada
 
dc.relation.ispartofJournal of Rheumatology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshCytokines - blood - immunology
 
dc.subject.meshInterleukin-17 - blood - immunology
 
dc.subject.meshInterleukin-23 - blood - immunology
 
dc.subject.meshLupus Erythematosus, Systemic - blood - immunology - physiopathology
 
dc.subject.meshTh1 Cells - immunology
 
dc.subject.meshTh2 Cells - immunology
 
dc.subjectCytokines
 
dc.subjectDisease activity
 
dc.subjectSystemic lupus erythematosus
 
dc.titleThe relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong